CD28: a signalling perspective

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

1992 • 1,156 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Inositol Trisphosphate and Calcium Signaling

1995 • 1,036 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses

1993 • 877 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.

1987 • 802 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Cyclosporin A, FK-506, and Rapamycin: Pharmacologic Probes of Lymphocyte Signal Transduction

1992 • 675 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo.

1992 • 558 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system

1993 • 541 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase

1995 • 520 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.

1995 • 489 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.

1991 • 422 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Rho as a regulator of the cytoskeleton

1995 • 386 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.

1995 • 349 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Molecular Cloning of SLP-76, a 76-kDa Tyrosine Phosphoprotein Associated with Grb2 in T Cells

1995 • 337 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

Phosphorylation of Raf by ceramide-activated protein kinase

1995 • 332 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Characterization of CTLA-4 structure and expression on human T cells.

1993 • 319 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

1995 • 304 citations

T cell receptor antagonists and partial agonists

1995 • 303 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Genomic organization and transcriptional regulation of the RANTES chemokine gene.

1993 • 273 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

The two-signal model of lymphocyte activation twenty-one years later

1992 • 233 citations

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.

1994 • 232 citations

Interactions of Cbl with Grb2 and Phosphatidylinositol 3′-Kinase in Activated Jurkat Cells

1995 • 217 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1994 • 202 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

Association of p62, a Multifunctional SH2- and SH3-Domain-Binding Protein, with src Family Tyrosine Kinases, Grb2, and Phospholipase Cγ-1

1995 • 198 citations

CD28 signals through acidic sphingomyelinase.

1995 • 194 citations

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

1992 • 194 citations

Cytotoxic T Lymphocyte-associated Molecule-4, a High Avidity Receptor for CD80 and CD86, Contains an Intracellular Localization Motif in Its Cytoplasmic Tail

1995 • 189 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

Analysis of the Role of Protein Kinase C-α, -ε, and -ζ in T Cell Activation

1995 • 184 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

Two-step TCRζ/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases

1994 • 176 citations

Ceramide: a signal for apoptosis or mitogenesis?

1995 • 173 citations

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

1990 • 173 citations

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras.

1994 • 169 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase

1991 • 166 citations

B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct.

1996 • 165 citations

Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.

1986 • 165 citations

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.

1995 • 164 citations

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.

1995 • 161 citations

The regulation and function of p21ras during T-cell activation and growth

1995 • 160 citations

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21^ras

1995 • 155 citations

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.

1992 • 153 citations

Ligation of B7 with CD28/CTLA‐4 on T cells results in CD40 ligand expression, interleukin‐4 secretion and efficient help for antibody production by B cells

1993 • 153 citations

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4⁺ T cells and induce similar patterns of cytokine secretion in vitro

1995 • 152 citations

Signal transduction events leading to T-cell lymphokine gene expression

1993 • 151 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Interleukin-2 Triggers a Novel Phosphatidylinositol 3-Kinase-Dependent MEK Activation Pathway

1995 • 145 citations

Both Extracellular Immunoglobin-like Domains of CD80 Contain Residues Critical for Binding T Cell Surface Receptors CTLA-4 and CD28

1995 • 143 citations

Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.

1993 • 142 citations

CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.

1994 • 132 citations

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

1995 • 125 citations

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1995 • 124 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells.

1992 • 118 citations

Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT

1995 • 118 citations

CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signaling.

1993 • 116 citations

Prolonged IL-2 receptor alpha/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. Demonstration of combined transcriptional and post-transcriptional regulation.

1992 • 115 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells

1996 • 108 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase.

1996 • 102 citations

CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

1994 • 102 citations

Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3-Kinase

1995 • 100 citations

Interleukin 2- and Polyomavirus Middle T Antigen-Induced Modification of Phosphatidylinositol 3-Kinase Activity in Activated T Lymphocytes

1991 • 98 citations

Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.

1994 • 94 citations

CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway.

1992 • 92 citations

Identification of Rlk, a Novel Protein Tyrosine Kinase with Predominant Expression in the T Cell Lineage

1995 • 92 citations

A major costimulatory molecule on antigen-presenting cells, CTLA4 ligand A, is distinct from B7.

1993 • 91 citations

B7/CD28-dependent and -independent induction of CD40 ligand expression.

1995 • 91 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation

1993 • 84 citations

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins.

1994 • 81 citations

Signal Transduction by CD28 Costimulatory Receptor on T Cells

1996 • 77 citations

Functional LCK Is Required for Optimal CD28-mediated Activation of the TEC Family Tyrosine Kinase EMT/ITK

1996 • 77 citations

Inhibition of CD28‐mediated T cell costimulation by the phosphoinositide 3‐kinase inhibitor wortmannin

1995 • 75 citations

In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

1994 • 75 citations

CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events

1993 • 74 citations

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion

1995 • 74 citations

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.

1994 • 67 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

Sphingomyelin‐ceramide turnover in CD28 costimulatory signaling

1995 • 66 citations

Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 • 63 citations

CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation

1995 • 61 citations

CD28 costimulation up-regulates long-term IL-2R beta expression in human T cells through combined transcriptional and post-transcriptional regulation.

1995 • 61 citations

B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.

1992 • 59 citations

Activation of src Family Kinase lck Following CD28 Crosslinking in the Jurkat Leukemic Cell Line

1994 • 59 citations

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

1992 • 55 citations

The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase

1994 • 55 citations

Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.

1992 • 53 citations

Intracellular Signalling: PI 3-kinase puts GTP on the Rac

1995 • 53 citations

Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin

1995 • 48 citations

Tyrosine phosphorylation and association with phospholipase C gamma-1 of the GAP-associated 62-kD protein after CD2 stimulation of Jurkat T cell.

1993 • 47 citations

CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis.

1995 • 46 citations

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.

1995 • 45 citations

T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck.

1994 • 45 citations

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

1993 • 44 citations

Monoclonal antibody 2D10 recognizes a novel T cell costimulatory molecule on activated murine B lymphocytes.

1994 • 44 citations

CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca²⁺‐independent costimulatory activity

1994 • 42 citations

Comparison of CD28‐B7.1 and B7.2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production

1996 • 40 citations

T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways

1991 • 39 citations

Cross‐linking CD28 leads to activation of 70‐kDa S6 kinase

1994 • 37 citations

Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.

1995 • 35 citations

CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the MAP kinases: ERK2 and Jun kinases

1996 • 34 citations

Functional Interactions of Phosphatidylinositol 3-Kinase with GTPase-Activating Protein in 3T3-L1 Adipocytes

1996 • 33 citations

Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56^lck Complex: the p56^lck SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase

1993 • 27 citations

Antibody ligation of CD7 leads to association with phosphoinositide 3‐kinase and phosphatidylinositol 3,4,5‐trisphosphate formation in T lymphocytes

1995 • 27 citations

Regulation of T-Cell Lymphokine Gene Transcription by the Accessory Molecule CD28

1992 • 26 citations

CD28 Receptor Crosslinking Induces Tyrosine Phosphorylation of PLCγ1

1992 • 24 citations

Effect of CD28 Signal Transduction on c-Rel in Human Peripheral Blood T Cells

1994 • 21 citations

Functional expression of human CD28 in murine T cell hybridomas

1994 • 14 citations

Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells

1994 • 7 citations

Involvement of Phosphatidylinositol 3-kinase in the Activation of p70 S6 Kinase by the T Cell Costimulatory Molecule CD28

1996 • 2 citations