Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

Caspases: the executioners of apoptosis

1997 • 4,674 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

1999 • 2,796 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1995 • 1,662 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

The Proapoptotic Activity of the Bcl-2 Family Member Bim Is Regulated by Interaction with the Dynein Motor Complex

1999 • 1,045 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

2001 • 815 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses

1996 • 728 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

2001 • 453 citations

Cytokine-induced survival of activated T cellsin vitroandin vivo

1998 • 395 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells

2000 • 355 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Immunological adjuvants promote activated T cell survival via induction of Bcl-3

2001 • 228 citations

The Proapoptotic BH3-Only Protein Bim Is Expressed in Hematopoietic, Epithelial, Neuronal, and Germ Cells

2000 • 227 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors

2001 • 210 citations

Tissue-Specific Bcl-2 Protein Partners in Apoptosis: An Ovarian Paradigm

2000 • 171 citations

Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo

1995 • 134 citations

BOD (Bcl-2-Related Ovarian Death Gene) Is an Ovarian BH3 Domain-Containing Proapoptotic Bcl-2 Protein Capable of Dimerization with Diverse Antiapoptotic Bcl-2 Members

1998 • 128 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice.

1993 • 125 citations

The Bcl-2 family and cell death regulation

1998 • 119 citations

Expression and location of pro-apoptotic Bcl-2 family protein BAD in normal human tissues and tumor cell lines.

1998 • 113 citations

Superantigen and endotoxin synergize in the induction of lethal shock

1997 • 109 citations

Newly discovered role for Fas ligand in the cell-cycle arrest of CD4+ T cells

1998 • 109 citations

Bystander Virus Infection Prolongs Activated T Cell Survival

1999 • 90 citations

Implantation of IL-2-containing osmotic pump prolongs the survival of superantigen-reactive T cells expanded in mice injected with bacterial superantigen.

1996 • 82 citations

A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice

1994 • 81 citations

TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

2000 • 75 citations

T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions

1996 • 66 citations

Isotypic Exclusion of γδ T Cell Receptors in Transgenic Mice Bearing a Rearranged β-Chain Gene

1988 • 61 citations

Mechanisms of peripheral T cell deletion: anergized T cells are Fas resistant but undergo proliferation‐associated apoptosis

1996 • 42 citations

In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cells.

1994 • 37 citations

Analysis of BAX expression in human tissues using the Anti-BAX, 4F11 monoclonal antibody on paraffin sections

1998 • 30 citations

Rapid clearance of the bacterial superantigen staphylococcal enterotoxin B in vivo

1996 • 29 citations

A Single Injection of Staphylococcus aureus Enterotoxin B Reduces Autoimmunity in MRL/lpr Mice

1994 • 27 citations