Lymphocytes with a complex: adapter proteins in antigen receptor signaling

The importance of being proline: the interaction of proline‐rich motifs in signaling proteins with their cognate domains

2000 • 1,198 citations

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

1999 • 1,045 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

1997 • 558 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

BLNK

1998 • 501 citations

Ubiquitination: RING for destruction?

2000 • 496 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

An Essential Role for BLNK in Human B Cell Development

1999 • 352 citations

Signal transduction: hanging on a scaffold

2000 • 341 citations

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

1999 • 321 citations

BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells

1999 • 313 citations

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1999 • 299 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

2000 • 295 citations

Regulation of PAK Activation and the T Cell Cytoskeleton by the Linker Protein SLP-76

1998 • 268 citations

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

1999 • 245 citations

Crystal Structures of the XLP Protein SAP Reveal a Class of SH2 Domains with Extended, Phosphotyrosine-Independent Sequence Recognition

1999 • 244 citations

The RasGAP-Binding Protein p62dok Is a Mediator of Inhibitory FcγRIIB Signals in B Cells

2000 • 238 citations

From Src Homology domains to other signaling modules: proposal of the `protein recognition code'

1998 • 232 citations

Membrane rafts and signaling by the multichain immune recognition receptors

2000 • 226 citations

Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling

1998 • 226 citations

BLNK

2000 • 221 citations

Xid-like Phenotypes

2000 • 195 citations

Dok-3, a Novel Adapter Molecule Involved in the Negative Regulation of Immunoreceptor Signaling

2000 • 186 citations

Ras regulation and function in lymphocytes

2000 • 179 citations

Role of the rasGAP-associated docking protein p62^dokin negative regulation of B cell receptor-mediated signaling

2000 • 178 citations

The PH superfold: a structural scaffold for multiple functions

1999 • 168 citations

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

2000 • 155 citations

Adaptor proteins in lymphocyte antigen-receptor signaling

1998 • 155 citations

Physiological signals and oncogenesis mediated through Crk family adapter proteins

1998 • 139 citations

Diversity in protein recognition by PTB domains

1999 • 131 citations

HPK1 Is Activated by Lymphocyte Antigen Receptors and Negatively Regulates AP-1

2000 • 123 citations

cbl-3: a new mammalian cbl family protein

1999 • 117 citations

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

1999 • 115 citations

Src-like Adaptor Protein (Slap) Is a Negative Regulator of T Cell Receptor Signaling

2000 • 115 citations

Adaptor Function for the Syk Kinases–Interacting Protein 3BP2 in IL-2 Gene Activation

1998 • 112 citations

The role of membrane-associated adaptors in T cell receptor signalling

2000 • 111 citations

Cloning and Characterization of Human Lnk, an Adaptor Protein with Pleckstrin Homology and Src Homology 2 Domains that Can Inhibit T Cell Activation

2000 • 110 citations

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

1999 • 109 citations

The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events

1998 • 104 citations

Tec family kinases in lymphocyte signaling and function

2000 • 103 citations

Characterization of a Novel Member of the DOK Family That Binds and Modulates Abl Signaling

1999 • 102 citations

Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation

1999 • 99 citations

Adapter proteins in lymphocyte antigen-receptor signaling

2000 • 95 citations

A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase

2000 • 94 citations

Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding

2000 • 83 citations

Gab-Family Adapter Molecules in Signal Transduction of Cytokine and Growth Factor Receptors, and T and B Cell Antigen Receptors

2000 • 80 citations

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

1999 • 79 citations

Cutting Edge: SLP-76 Cooperativity with FYB/FYN-T in the Up-Regulation of TCR-Driven IL-2 Transcription Requires SLP-76 Binding to FYB at Tyr595 and Tyr651

1999 • 68 citations

Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase

1999 • 63 citations

Functional Association between SLAP-130 and SLP-76 in Jurkat T Cells

2000 • 58 citations

Lymphocyte signaling: Cbl sets the threshold for autoimmunity

2000 • 51 citations

Regulation of B cell function by linker proteins

2000 • 43 citations

Intracellular adapter molecules

2000 • 34 citations

Lymphocyte Antigen Receptor Signal Integration and Regulation by the SHC Adaptor

1999 • 17 citations

The Unexpected Complexity of FcγRIIB Signal Transduction

1999 • 13 citations