AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

1995 • 2,534 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification ¹

1995 • 2,199 citations

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

1998 • 2,096 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Calcium signaling

1995 • 1,905 citations

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1997 • 1,905 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Active and Inactive Protein Kinases: Structural Basis for Regulation

1996 • 1,361 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

1996 • 1,277 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1998 • 1,097 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

1998 • 1,050 citations

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1998 • 1,049 citations

Role of Translocation in the Activation and Function of Protein Kinase B

1997 • 1,044 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

CREB Is a Regulatory Target for the Protein Kinase Akt/PKB

1998 • 939 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Regulation of protein kinase C

1997 • 919 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

1991 • 900 citations

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ

1998 • 886 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

Mechanism of activation and function of protein kinase B

1998 • 753 citations

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

1987 • 752 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1997 • 740 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1998 • 680 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Regulation of Cardiac Na ⁺ ,Ca ²⁺ Exchange and K _ATP Potassium Channels by PIP ₂

1996 • 655 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

1997 • 591 citations

Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice

1996 • 587 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

A presynaptic inositol-5-phosphatase

1996 • 573 citations

Phospholipid signaling

1995 • 561 citations

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.

1996 • 560 citations

Ras signalling and apoptosis

1998 • 559 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

The modular phosphorylation and activation of p70^s6k

1997 • 539 citations

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.

1991 • 537 citations

An essential role for a phospholipid transfer protein in yeast Golgi function

1990 • 534 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

Severe impairment of permatogenesis in mice lacking the CREM gene

1996 • 513 citations

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1998 • 512 citations

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

1998 • 510 citations

ATP-dependent inositide phosphorylation required for Ca2+-activated secretion

1995 • 508 citations

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

1997 • 505 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

1997 • 489 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Molecular cloning and characterisation of a novel putative protein‐serine kinase related to the cAMP‐dependent and protein kinase C families

1991 • 485 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC

1998 • 479 citations

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation

1996 • 469 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase

1992 • 464 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

TOR signalling and control of cell growth

1997 • 458 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1994 • 450 citations

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

1998 • 447 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Structure and Function of Cyclic Nucleotide-Dependent Protein Kinases

1994 • 442 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

The C. elegans PTEN Homolog, DAF-18, Acts in the Insulin Receptor-like Metabolic Signaling Pathway

1998 • 440 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1997 • 436 citations

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation

1997 • 433 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Switching Signals On or Off by Receptor Dimerization

1998 • 428 citations

Mitogenic Signaling via G Protein-Coupled Receptors

1996 • 425 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Transformation of Chicken Cells by the Gene Encoding the Catalytic Subunit of PI 3-Kinase

1997 • 414 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Signaling by Phosphoinositide-3,4,5-Trisphosphate Through Proteins Containing Pleckstrin and Sec7 Homology Domains

1997 • 405 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

1998 • 383 citations

E2F3 activity is regulated during the cell cycle and is required for the induction of S phase

1998 • 382 citations

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

1997 • 377 citations

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

1998 • 369 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 368 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

Insulin signal transduction through protein kinase cascades.

1998 • 364 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 358 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein

1991 • 348 citations

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

1998 • 344 citations

Structure and function of theprotein tyrosine phosphatases

1996 • 339 citations

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

1998 • 338 citations

Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

1998 • 333 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 330 citations

PI 3-kinase: structural and functional analysis of intersubunit interactions.

1994 • 329 citations

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1996 • 328 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1995 • 311 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation

1998 • 308 citations

Arachidonic acid in cell signaling

1993 • 295 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

The Akt kinase: Molecular determinants of oncogenicity

1998 • 294 citations

Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

1998 • 293 citations

New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin

1997 • 293 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.

1997 • 291 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

TCF/LEF factors earn their wings

1997 • 288 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

1996 • 278 citations

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α

1998 • 275 citations

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.

1977 • 273 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Activation of protein kinase B (Akt/RAC‐protein kinase) by cellular stress and its association with heat shock protein Hsp27

1997 • 270 citations

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

1998 • 265 citations

Signal transduction and membrane traffic: The PITP/phosphoinositide connection

1995 • 261 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

p50^cdc37 Acting in Concert with Hsp90 Is Required for Raf-1 Function

1999 • 259 citations

Essential role for diacylglycerol in protein transport from the yeast Golgi complex

1997 • 257 citations

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1996 • 249 citations

Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells

1998 • 249 citations

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997 • 247 citations

Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities.

1994 • 245 citations

The Principal Rapamycin-Sensitive p70^s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

1996 • 245 citations

Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.

1998 • 244 citations

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles

1998 • 242 citations

Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells

1997 • 241 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

The Structure and Function of P55^PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

1995 • 235 citations

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

1996 • 234 citations

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

1994 • 234 citations

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1998 • 230 citations

Hepatic Nuclear Factor 3- and Hormone-Regulated Expression of the Phosphoenolpyruvate Carboxykinase and Insulin-Like Growth Factor-Binding Protein 1 Genes

1995 • 226 citations

The Inositol Phosphatase SHIP Inhibits Akt/PKB Activation in B Cells

1998 • 226 citations

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1996 • 223 citations

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

1998 • 222 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes

1997 • 218 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase

1997 • 215 citations

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.

1995 • 210 citations

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1998 • 209 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

1998 • 192 citations

Activation of bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain

1995 • 191 citations

Molecular Cloning and Characterization of a New Member of the RAC Protein Kinase Family: Association of the Pleckstrin Homology Domain of 3 Types of RAC Protein Kinase with Protein Kinase C Subspecies and βγ Subunits of G Proteins

1995 • 189 citations

Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

1998 • 187 citations

Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

1997 • 186 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

1998 • 183 citations

The vibrator Mutation Causes Neurodegeneration via Reduced Expression of PITPα: Positional Complementation Cloning and Extragenic Suppression

1997 • 182 citations

Molecular cloning of a second form of rac protein kinase.

1991 • 182 citations

Src-induced activation of inducible T cell kinase (ITK) requires phosphatidylinositol 3-kinase activity and the Pleckstrin homology domain of inducible T cell kinase

1997 • 178 citations

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha ) promoted by hyperosmotic stress

1998 • 175 citations

Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.

1993 • 173 citations

cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner

1997 • 169 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity

1997 • 169 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

1992 • 166 citations

The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.

1993 • 164 citations

Protein Kinase B/Akt Mediates Effects of Insulin on Hepatic Insulin-like Growth Factor-binding Protein-1 Gene Expression through a Conserved Insulin Response Sequence

1998 • 164 citations

Protein traffic in the yeast endocytic and vacuolar protein sorting pathways

1998 • 164 citations

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

1997 • 161 citations

AH/PH Domain-Mediated Interaction between Akt Molecules and Its Potential Role in Akt Regulation

1995 • 161 citations

Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain

1996 • 154 citations

Requirement for negative charge on “activation loop” of protein kinase C.

1994 • 153 citations

Phospholipid signalling in the nucleus

1998 • 153 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

The Saccharomyces cerevisiae phosphatidylinositol-transfer protein effects a ligand-dependent inhibition of choline-phosphate cytidylyltransferase activity.

1995 • 150 citations

Insulin Receptor Substrate 1 Binds Two Novel Splice Variants of the Regulatory Subunit of Phosphatidylinositol 3-Kinase in Muscle and Brain

1996 • 148 citations

Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway

1997 • 143 citations

PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor

1999 • 142 citations

Identification and Cloning of Centaurin-α

1996 • 142 citations

Autoactivation of catalytic (C alpha) subunit of cyclic AMP-dependent protein kinase by phosphorylation of threonine 197.

1993 • 141 citations

The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function

1995 • 139 citations

The diversity and possible functions of the inositol polyphosphate 5-phosphatases

1998 • 138 citations

Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C

1989 • 138 citations

Genetic analysis of protein kinase B (AKT) in Drosophila

1998 • 138 citations

Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats

1997 • 138 citations

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995 • 137 citations

Phosphorylation Sites in the Autoinhibitory Domain Participate in p70s6k Activation Loop Phosphorylation

1998 • 135 citations

Deletion ofPTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease

1997 • 135 citations

A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets

1998 • 133 citations

Evidence That a Phosphatidylinositol 3,4,5-Trisphosphate-binding Protein Can Function in Nucleus

1999 • 130 citations

Threonine-497 is a critical site for permissive activation of protein kinase Cα

1994 • 129 citations

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

1998 • 129 citations

Akt-2 Binds to Glut4-containing Vesicles and Phosphorylates Their Component Proteins in Response to Insulin

1999 • 128 citations

Human Phosphoinositide 3-Kinase C2β, the Role of Calcium and the C2 Domain in Enzyme Activity

1998 • 127 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

1995 • 127 citations

Structural and functional analysis of pp70S6k.

1995 • 126 citations

Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase*

1998 • 125 citations

The Activation of Glycogen Synthase by Insulin Switches from Kinase Inhibition to Phosphatase Activation during Adipogenesis in 3T3-L1 Cells

1998 • 124 citations

Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity.

1996 • 120 citations

The protein kinase C and protein kinase C related gene families

1995 • 119 citations

A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene

1996 • 119 citations

Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes

1997 • 119 citations

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

1996 • 117 citations

Phospholipid-binding protein domains

1998 • 116 citations

Traps to catch unwary oncogenes

1998 • 113 citations

Cdc37: a protein kinase chaperone?

1997 • 113 citations

The SH2 domain containing inositol 5‐phosphatase SHIP2 displays phosphatidylinositol 3,4,5‐trisphosphate and inositol 1,3,4,5‐tetrakisphosphate 5‐phosphatase activity

1998 • 112 citations

PIPkins1We introduce here the abbreviation PIPkin (an abbreviation we have used in our lab for years) for cogent reasons. Previously, PtdIns4P 5-kinase was the favoured abbreviation, but in view of the extensive revision and uncertainty as to substrates and products that we discuss in this review, only PtdInsP kinase would now suffice. Moreover, we have recently recorded evidence that type II PIPkin is subject to multiple phosphorylations by protein kinases [1]. As we progress in our …

1998 • 110 citations

Cloning, Characterization, and Expression of a Novel Zn²⁺-Binding FYVE Finger-Containing Phosphoinositide Kinase in Insulin-Sensitive Cells

1999 • 109 citations

A Type II Phosphoinositide 3-Kinase Is Stimulated via Activated Integrin in Platelets

1998 • 107 citations

The Tec29 Tyrosine Kinase Is Required during Drosophila Embryogenesis and Interacts with Src64 in Ring Canal Development

1998 • 104 citations

Dual Requirement for a Newly Identified Phosphorylation Site in p70^s6k

1997 • 103 citations

E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions.

1994 • 102 citations

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

1997 • 102 citations

Synaptojanin 2, a Novel Synaptojanin Isoform with a Distinct Targeting Domain and Expression Pattern

1997 • 101 citations

Molecular genetics of life span in C. elegans: How much does it teach us?

1998 • 101 citations

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

1995 • 101 citations

Thymic lymphoma induction by the AKT8 murine retrovirus.

1988 • 100 citations

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

1993 • 98 citations

Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells.

1994 • 93 citations

Structures of SH2 and SH3 domains

1993 • 92 citations

Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase.

1994 • 90 citations

Protein Kinase B/Akt Induces Resumption of Meiosis in Xenopus Oocytes

1998 • 85 citations

Disruption of three phosphatidylinositol-polyphosphate 5-phosphatase genes from Saccharomyces cerevisiae results in pleiotropic abnormalities of vacuole morphology, cell shape, and osmohomeostasis.

1997 • 85 citations

Phosphatidylinositol 4-kinases

1998 • 84 citations

A Target of Phosphatidylinositol 3,4,5‐Trisphosphate with a Zinc Finger Motif Similar to that of the ADP‐Ribosylation‐Factor GTPase‐Activating Protein and Two Pleckstrin Homology Domains

1997 • 84 citations

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

1999 • 83 citations

Protein Kinase B/akt and Rab5 Mediate Ras Activation of Endocytosis

1998 • 82 citations

Biphasic Activation of PKBα/Akt In Platelets

1998 • 82 citations

SRC64 Regulates the Localization of a Tec-Family Kinase Required for Drosophila Ring Canal Growth

1998 • 80 citations

Inositol lipid 5-phosphatases-traffic signals and signal traffic

1997 • 80 citations

Physiological Phosphorylation of Protein Kinase A at Thr-197 Is by a Protein Kinase A Kinase

1998 • 80 citations

Phosphatidylinositol transfer proteins: the long and winding road to physiological function

1998 • 79 citations

Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells

1997 • 77 citations

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

1997 • 73 citations

Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase.

1995 • 73 citations

New insights into the role and mechanism of glycogen synthase activation by insulin

1997 • 71 citations

The AKT1 proto-oncogene maps to human chromosome 14, band q32

1988 • 71 citations

Cloning and expression of human brain type I inositol 1,4,5‐trisphosphate 5‐phosphatase High levels of mRNA in cerebellar Purkinje cells

1994 • 70 citations

Guanosine 5′-O-(3-Thiotriphosphate) (GTPγS) Stimulation of GLUT4 Translocation is Tyrosine Kinase-dependent

1998 • 69 citations

The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis

1998 • 69 citations

Evidence against protein kinase B as a mediator of contraction‐induced glucose transport and GLUT4 translocation in rat skeletal muscle

1998 • 67 citations

Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-Kinase, HsC2-PI3K

1997 • 66 citations

Cpk Is a Novel Class of Drosophila PtdIns 3-Kinase Containing a C2 Domain

1996 • 65 citations

Mechanisms of Ceramide-Mediated Apoptosis

1997 • 63 citations

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

1998 • 63 citations

Three distinct elements within the murine c-myc promoter are required for transcription.

1992 • 62 citations

Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells

1998 • 62 citations

Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.

1998 • 61 citations

Developmental Regulation of Expression and Activity of Multiple Forms of the Drosophila RAC Protein Kinase

1995 • 58 citations

v-Abl Activates c-myc Transcription through the E2F Site

1995 • 57 citations

Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation.

1996 • 54 citations

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

1994 • 51 citations

Cloning and Expression of a Human Placenta Inositol 1,3,4,5-tetrakisphosphate and Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase

1996 • 50 citations

Developmentally Regulated Alternative Splicing in a Novel Synaptojanin

1998 • 46 citations

Cloning and Characterization of a Human cDNA (INPPL1) Sharing Homology with Inositol Polyphosphate Phosphatases

1995 • 43 citations

Selective Recognition of Phosphatidylinositol 3,4,5-Trisphosphate by a Synthetic Peptide

1997 • 40 citations

Signaling Inositol Polyphosphate-5-phosphatase

1997 • 38 citations

A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the obGene Product, Leptin, in 3T3-L1 Adipocytes

1997 • 36 citations

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats

1997 • 34 citations

Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes

1997 • 34 citations

Activation of p70 S6 Kinase and erk-encoded Mitogen-activated Protein Kinases Is Resistant to High Cyclic Nucleotide Levels in Swiss 3T3 Fibroblasts

1995 • 33 citations

Mitogenic signaling via G protein-coupled receptors

1996 • 32 citations

Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase

1998 • 29 citations

Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase

1997 • 18 citations

A kinase-negative mutant of S49 mouse lymphoma cells is defective in posttranslational maturation of catalytic subunit of cyclic AMP-dependent protein kinase.

1991 • 10 citations

Deletion of PTEN in a patient with Bannayan‐Riley‐Ruvalcaba syndrome suggests allelism with Cowden disease

1997 • 8 citations

A Constitutively Active Version of the Ser/Thr Kinase Akt Induces Production of the ob Gene Product, Leptin, in 3T3-L1 Adipocytes

1997 • 4 citations