Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Phosphatidylinositol 3‐kinase

1994 • 649 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase

1995 • 223 citations

Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.

1994 • 205 citations

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.

1996 • 112 citations

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

1996 • 45 citations

A C-terminal Mutant of the G Protein β Subunit Deficient in the Activation of Phospholipase C-β

1996 • 30 citations