Gab-Family Adapter Proteins Act Downstream of Cytokine and Growth Factor Receptors and T- and B-Cell Antigen Receptors

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

1996 • 661 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

1996 • 572 citations

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 • 555 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

Recruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1

1995 • 535 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

A Novel Membrane Glycoprotein, SHPS-1, That Binds the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-2 in Response to Mitogens and Cell Adhesion

1996 • 443 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Signaling mechanisms through gp130: A model of the cytokine system

1997 • 371 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development

1995 • 330 citations

Gab1 Acts as an Adapter Molecule Linking the Cytokine Receptor gp130 to ERK Mitogen-Activated Protein Kinase

1998 • 287 citations

Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

1997 • 276 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling

1996 • 210 citations

Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.

1993 • 204 citations

Regulation of Colony-Stimulating Factor 1 Receptor Signaling by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

1996 • 199 citations

DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila

1996 • 180 citations

Regulation of antigen receptor signal transduction by protein tyrosine kinases

1996 • 179 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1

1996 • 167 citations

PTP1D is a positive regulator of the prolactin signal leading to beta-casein promoter activation.

1996 • 144 citations

The Phosphotyrosine Phosphatase SHP-2 Participates in a Multimeric Signaling Complex and Regulates T Cell Receptor (TCR) coupling to the Ras/Mitogen-activated Protein Kinase (MAPK) Pathway in Jurkat T Cells

1998 • 118 citations

Transmembrane signaling by antigen receptors of B and T lymphocytes

1995 • 109 citations

Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.

1996 • 108 citations

The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression

1996 • 100 citations

Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK

1997 • 97 citations

Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling

1996 • 95 citations

Growth response of acute myeloblastic leukemia cells to recombinant human thrombopoietin

1995 • 93 citations

Characterization of Two SHP-2-associated Binding Proteins and Potential Substrates in Hematopoietic Cells

1997 • 83 citations

Insulin Receptor Substrate-2 Is the Major 170-kDa Protein Phosphorylated on Tyrosine in Response to Cytokines in Murine Lymphohemopoietic Cells

1997 • 68 citations

Characterization of a Novel Tyrosine Phosphorylated 100-kDa Protein That Binds to SHP-2 and Phosphatidylinositol 3′-Kinase in Myeloid Cells

1997 • 58 citations

Interleukin-3 Induces Association of the Protein-tyrosine Phosphatase SHP2 and Phosphatidylinositol 3-Kinase with a 100-kDa Tyrosine-phosphorylated Protein in Hemopoietic Cells

1997 • 48 citations

A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes

1998 • 47 citations

Epidermal Growth Factor-induced Association of the SHPTP2 Protein Tyrosine Phosphatase with a 115-kDa Phosphotyrosine Protein

1995 • 32 citations

B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.

1998 • 26 citations

B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by FeγRIIB1-BCR Coligation

1998 • 21 citations