Structure, Function, and Control of Phosphoinositide-Specific Phospholipase C

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

FUNCTIONS OF LIPID RAFTS IN BIOLOGICAL MEMBRANES

1998 • 2,942 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

THE CAVEOLAE MEMBRANE SYSTEM

1998 • 1,947 citations

Calcium signaling

1995 • 1,905 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

1998 • 1,502 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

G Protein-coupled Receptors

1998 • 1,292 citations

LAT

1998 • 1,251 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

G Protein-coupled Receptors

1998 • 1,033 citations

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

1994 • 983 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

A Cell's Sense of Direction

1999 • 884 citations

Regulation of Phosphoinositide-specific Phospholipase C Isozymes

1997 • 866 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

C2-domains, Structure and Function of a Universal Ca2+-binding Domain

1998 • 835 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools

1998 • 820 citations

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

1998 • 819 citations

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

The C2 domain calcium‐binding motif: Structural and functional diversity

1996 • 784 citations

The Cytoskeleton and Cell Signaling: Component Localization and Mechanical Coupling

1998 • 783 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

1998 • 733 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Mammalian Membrane-bound Adenylyl Cyclases

1995 • 722 citations

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 • 688 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Signal characteristics of G protein-transactivated EGF receptor

1997 • 669 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Isolation of a putative phospholipase c gene of drosophila, norpA, and its role in phototransduction

1988 • 665 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion

2000 • 651 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases

1998 • 615 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Calcium-dependent Epidermal Growth Factor Receptor Transactivation Mediates the Angiotensin II-induced Mitogen-activated Protein Kinase Activation in Vascular Smooth Muscle Cells

1998 • 569 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

G _h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function

1994 • 550 citations

Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses

1994 • 538 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

1999 • 513 citations

Spatiotemporal Dynamics of Inositol 1,4,5-Trisphosphate That Underlies Complex Ca ²⁺ Mobilization Patterns

1999 • 500 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

The Molecular Architecture of Focal Adhesions

1995 • 479 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

TOR signalling and control of cell growth

1997 • 458 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator

1992 • 430 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins

1993 • 393 citations

REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D

1997 • 390 citations

G protein-coupled signal transduction pathways for interleukin-8

1993 • 385 citations

A gene encoding a phosphatidylinositol-specific phospholipase C is induced by dehydration and salt stress in Arabidopsis thaliana.

1995 • 372 citations

Cholesterol Depletion Delocalizes Phosphatidylinositol Bisphosphate and Inhibits Hormone-stimulated Phosphatidylinositol Turnover

1998 • 371 citations

Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice

1995 • 369 citations

Regulation of Phosphoinositide Phospholipases by Hormones, Neurotransmitters, and Other Agonists Linked to G Proteins

1996 • 362 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

1994 • 333 citations

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 330 citations

Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

1992 • 321 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

Activation of phospholipase C isozymes by G protein beta gamma subunits.

1993 • 306 citations

Angiotensin II Signal Transduction in Vascular Smooth Muscle

1997 • 306 citations

Phospholipase C isozymes selectively couple to specific neurotransmitter receptors

1997 • 302 citations

Persistent Multiple Climbing Fiber Innervationof Cerebellar Purkinje Cellsin Mice Lacking mGluR1

1997 • 300 citations

MOLECULAR GENETIC ANALYSIS OF SYNAPTIC PLASTICITY, ACTIVITY-DEPENDENT NEURAL DEVELOPMENT, LEARNING, AND MEMORY IN THE MAMMALIAN BRAIN

1997 • 299 citations

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1998 • 296 citations

Requirement for the PDZ Domain Protein, INAD, for Localization of the TRP Store-Operated Channel to a Signaling Complex

1997 • 292 citations

Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.

1994 • 291 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family.

1992 • 285 citations

Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines.

1991 • 278 citations

Members of the Gq alpha subunit gene family activate phospholipase C beta isozymes.

1992 • 277 citations

Stimulation of phospholipase C by guanine‐nucleotide‐binding protein βγ subunits

1992 • 277 citations

Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

1997 • 276 citations

Dynamic Targeting of the Agonist-stimulated m2 Muscarinic Acetylcholine Receptor to Caveolae in Cardiac Myocytes

1997 • 275 citations

The unfolded protein response: an intracellular signalling pathway with many surprising features

1998 • 274 citations

Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits

1993 • 262 citations

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

1997 • 259 citations

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.

1991 • 258 citations

Bradykinin Sequesters B2 Bradykinin Receptors and the Receptor-coupled Gα Subunits Gαq and Gαiin Caveolae in DDT1 MF-2 Smooth Muscle Cells

1997 • 256 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

Regulation of Phospholipase D by Protein Kinase C Is Synergistic with ADP-ribosylation Factor and Independent of Protein Kinase Activity

1996 • 251 citations

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

1995 • 249 citations

Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains.

1996 • 246 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

Platelet actuation

1995 • 238 citations

Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C.

1989 • 235 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C.

1994 • 225 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor

1996 • 220 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.

1993 • 213 citations

Feedback regulation of phospholipase C-beta by protein kinase C.

1990 • 212 citations

A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.

1995 • 212 citations

The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD.

1996 • 212 citations

Organization of G Proteins and Adenylyl Cyclase at the Plasma Membrane

1997 • 211 citations

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.

1993 • 211 citations

Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin.

1992 • 206 citations

INTERFACIAL ENZYMOLOGY OF GLYCEROLIPID HYDROLASES: Lessons from Secreted Phospholipases A₂

1995 • 204 citations

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.

1994 • 204 citations

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

1996 • 200 citations

Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis.

1995 • 199 citations

The Role of Carboxyl-terminal Basic Amino Acids in Gqα-dependent Activation, Particulate Association, and Nuclear Localization of Phospholipase C-β1

1996 • 198 citations

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

1992 • 197 citations

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

1993 • 195 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C

1996 • 193 citations

A Pleckstrin Homology Domain Specific for Phosphatidylinositol 4,5-Bisphosphate (PtdIns-4,5-P2) and Fused to Green Fluorescent Protein Identifies Plasma Membrane PtdIns-4,5-P2 as Being Important in Exocytosis

2000 • 191 citations

Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.

1991 • 191 citations

Selective G Protein Coupling by C-C Chemokine Receptors

1996 • 191 citations

Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones

1988 • 190 citations

Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

1997 • 186 citations

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

1993 • 186 citations

Regulation of inositol lipid-specific phospholipase Cδ by changes in Ca2+ ion concentrations

1997 • 186 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

1991 • 184 citations

The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

1998 • 183 citations

Requirement for Phosphatidylinositol Transfer Protein in Epidermal Growth Factor Signaling

1995 • 180 citations

Evidence That Phospholipase δ1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling

1996 • 180 citations

Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.

1993 • 179 citations

Regulation of Phospholipid Biosynthesis in the Yeast Saccharomyces cerevisiae

1996 • 179 citations

G protein beta gamma subunits. Simplified purification and properties of novel isoforms.

1994 • 178 citations

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

1990 • 178 citations

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

1993 • 177 citations

Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.

1992 • 176 citations

Attenuation of G _i - and G _q -mediated signaling by expression of RGS4 or GAIP in mammalian cells

1997 • 176 citations

Electroporation of pp60c− Antibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 175 citations

TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae

1998 • 173 citations

Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

1998 • 172 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

The plant phosphoinositide system

1992 • 166 citations

Phosphatidylinositol 3,4,5-Trisphosphate-dependent Stimulation of Phospholipase C-γ2 Is an Early Key Event in FcγRIIA-mediated Activation of Human Platelets

1998 • 165 citations

Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol.

1995 • 162 citations

Phosphoinositide-specific phospholipase C-.delta.1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

1992 • 162 citations

The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.

1993 • 161 citations

PDZ domain proteins: Scaffolds for signaling complexes

1997 • 161 citations

A Second Type of Rat Phosphoinositide-specific Phospholipase C Containing a src-related Sequence Not Essential for Phosphoinositide-hydrolyzing Activity

1989 • 160 citations

Proteolytic fragments of phosphoinositide-specific phospholipase C-delta 1. Catalytic and membrane binding properties

1993 • 160 citations

Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q.

1993 • 158 citations

The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

1998 • 157 citations

Cell Signalling Through Guanine‐Nucleotide‐Binding Regulatory Proteins (G Proteins) and Phospholipases

1997 • 157 citations

Receptor tyrosine kinase substrates: src homology domains and signal transduction

1992 • 156 citations

Regulatory recruitment of signalling molecules to the cell membrane by pleckstrinhomology domains

1997 • 155 citations

Characterization of a Novel Mammalian RGS Protein That Binds to Gα Proteins and Inhibits Pheromone Signaling in Yeast

1997 • 155 citations

Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.

1993 • 154 citations

Catalytic Domain of Phosphoinositide-specific Phospholipase C (PLC)

1998 • 153 citations

Phospholipid signalling in the nucleus

1998 • 153 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

1994 • 151 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Replacements of Single Basic Amino Acids in the Pleckstrin Homology Domain of Phospholipase C-δ1 Alter the Ligand Binding, Phospholipase Activity, and Interaction with the Plasma Membrane

1998 • 146 citations

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

1992 • 146 citations

A Ternary Metal Binding Site in the C2 Domain of Phosphoinositide-Specific Phospholipase C-δ1^,

1997 • 146 citations

Ion channel targeting in neurons

1997 • 145 citations

G protein-linked signaling pathways control the developmental program of dictyostelium

1994 • 145 citations

Roles of phospholipase C β2 in chemoattractant-elicited responses

1997 • 143 citations

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1.

1994 • 141 citations

Collagen stimulates tyrosine phosphorylation of phospholipase C‐γ2 but not phospholipase C‐γ1 in human platelets

1994 • 141 citations

Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors

1996 • 139 citations

Putative inositol 1,4,5-trisphosphate binding proteins in rat brain cytosol.

1992 • 139 citations

Calcium Release at Fertilization in Starfish Eggs Is Mediated by Phospholipase Cγ

1997 • 139 citations

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.

1990 • 136 citations

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

1996 • 136 citations

A Trk nerve growth factor (NGF) receptor point mutation affecting interaction with phospholipase C-gamma 1 abolishes NGF-promoted peripherin induction but not neurite outgrowth.

1994 • 132 citations

Phospholipase C-δ1 Is Activated by Capacitative Calcium Entry That Follows Phospholipase C-β Activation upon Bradykinin Stimulation

1999 • 131 citations

Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization.

1989 • 130 citations

Interaction between the epidermal growth factor receptor and phosphoinositide kinases.

1991 • 130 citations

A secreted 80 × 103M r protein mediates sensing of cell density and the onset of development in Dictyostelium

1991 • 130 citations

The drosophila dgq gene encodes a Gα protein that mediates phototransduction

1994 • 129 citations

Somatostatin Receptor-mediated Signaling in Smooth Muscle

1996 • 129 citations

Phospholipase C β4 is involved in modulating the visual response in mice

1996 • 127 citations

Molecular and Enzymatic Characterization of Three Phosphoinositide-Specific Phospholipase C Isoforms from Potato1

1998 • 127 citations

Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.

1996 • 124 citations

A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus

1996 • 124 citations

Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C

1990 • 122 citations

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

1995 • 122 citations

Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.

1991 • 121 citations

Structural Mapping of the Catalytic Mechanism for a Mammalian Phosphoinositide-Specific Phospholipase C^,

1997 • 121 citations

Temporal Dispersion of Activation of Phospholipase C-β1 and -γ Isoforms by Angiotensin II in Vascular Smooth Muscle Cells

1998 • 121 citations

Dynamics of phosphatidylinositol 4,5-bisphosphate in actin-rich structures

2000 • 119 citations

Effect of Monolayer Surface Pressure on the Activities of Phosphoinositide-Specific Phospholipase C-.beta.1, -.gamma.1, and -.delta.1

1994 • 119 citations

Selective activation of phospholipase C by recombinant G-protein alpha- and beta gamma-subunits.

1994 • 118 citations

Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.

1986 • 118 citations

Localization of a Binding Site for Phosphatidylinositol 4,5-Bisphosphate on Human Profilin

1995 • 117 citations

Phosphatidylinositol 4,5-Bisphosphate Binding to the Pleckstrin Homology Domain of Phospholipase C-δ1 Enhances Enzyme Activity

1996 • 115 citations

Tissue- and cell type-specific expression of mRNAS for four types of inositol phospholipid-specific phospholipase C

1989 • 114 citations

Interaction Site of GTP Binding Gh (Transglutaminase II) with Phospholipase C

1995 • 114 citations

Phosphorylation of Phospholipase C-γ by cAMP-dependent Protein Kinase

1989 • 112 citations

Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq.

1994 • 109 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

Two forms of phospholipase C-beta 1 generated by alternative splicing.

1994 • 106 citations

Molecular Cloning, Splice Variants, Expression, and Purification of Phospholipase C-δ;4

1996 • 106 citations

Angiotensin II-induced Association of Phospholipase Cγ1 with the G-protein-coupled AT1 Receptor

1998 • 106 citations

Transglutaminase II: A New Class of GTP-Binding Protein with New Biological Functions

1997 • 105 citations

α1-Adrenergic Receptor Signaling via Gh Is Subtype Specific and Independent of Its Transglutaminase Activity

1996 • 104 citations

C2 domain conformational changes in phospholipase C-δ1

1996 • 104 citations

Activation of phospholipase C beta 4 by heterotrimeric GTP-binding proteins.

1994 • 104 citations

Effects of CapG overexpression on agonist-induced motility and second messenger generation.

1995 • 104 citations

Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-γ2 by the M-CSF receptor is necessary for differentiation signaling

1997 • 102 citations

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.

1994 • 102 citations

Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.

1994 • 102 citations

A Drosophila phospholipase C gene that is expressed in the central nervous system

1991 • 101 citations

Multiple forms of phosphoinositide-specific phospholipase C and different modes of activation

1991 • 100 citations

Wortmannin-Sensitive Phosphorylation, Translocation, and Activation of PLCγ1, but Not PLCγ2, in Antigen-stimulated RBL-2H3 Mast Cells

1998 • 100 citations

Requirement for Phospholipase C-γ1 Enzymatic Activity in Growth Factor-Induced Mitogenesis

1998 • 100 citations

CD38 signal transduction in human B cell precursors. Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and phosphatidylinositol 3-kinase.

1996 • 99 citations

Characterization of a plasma membrane‐associated phosphoinositide‐specific phospholipase C from soybean

1995 • 99 citations

A Mutation in PLC1, a Candidate Phosphoinositide-Specific Phospholipase C Gene from Saccharomyces cerevisiae, Causes Aberrant Mitotic Chromosome Segregation

1993 • 99 citations

S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C.

1989 • 99 citations

Phosphorylation of Serine 1105 by Protein Kinase A Inhibits Phospholipase Cβ3 Stimulation by Gαq

1998 • 98 citations

Phospholipase C-β1 Directly Accelerates GTP Hydrolysis by Gαq and Acceleration Is Inhibited by Gβγ Subunits

1999 • 98 citations

Nuclear Diacylglycerol Produced by Phosphoinositide-specific Phospholipase C Is Responsible for Nuclear Translocation of Protein Kinase C-α

1998 • 98 citations

Differential Association of the Pleckstrin Homology Domains of Phospholipases C-β₁, C-β₂, and C-δ₁ with Lipid Bilayers and the βγ Subunits of Heterotrimeric G Proteins

1999 • 97 citations

Phospholipase C-γ1: Regulation of enzyme function and role in growth factor-dependent signal transduction

1997 • 97 citations

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

1994 • 97 citations

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

1996 • 96 citations

Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins.

1994 • 96 citations

Decreased expression of phospholipase C-beta 2 isozyme in human platelets with impaired function

1996 • 95 citations

Interactions of G _h /transglutaminase with phospholipase Cδ1 and with GTP

1999 • 93 citations

Cyclic AMP-insensitive Activation of c-Src and Syk Protein-tyrosine Kinases through Platelet Membrane Glycoprotein VI

1995 • 92 citations

Potential Role for a Regulator of G Protein Signaling (RGS3) in Gonadotropin-Releasing Hormone (GnRH) Stimulated Desensitization

1997 • 92 citations

Gelsolin Modulates Phospholipase C Activity In Vivo through Phospholipid Binding

1997 • 90 citations

Regulation of inositol lipid kinases by Rho and Rac

1998 • 90 citations

Essential role for nuclear phospholipase C beta1 in insulin-like growth factor I-induced mitogenesis.

1997 • 89 citations

Identification and biochemical characterization of an 80 kilodalton GTP-binding/transglutaminase from rabbit liver nuclei

1995 • 89 citations

Structural requirements of phosphatidylinositol‐specific phospholipase C δ₁ for enzyme activity

1993 • 88 citations

Functional characterization of phosphoinositide-specific phospholipase C-beta 1 and -beta 3 in intestinal smooth muscle

1995 • 88 citations

Determination of the Affinities between Heterotrimeric G Protein Subunits and Their Phospholipase C-β Effectors

1999 • 88 citations

Cutting edge: association of phospholipase C-gamma 2 Src homology 2 domains with BLNK is critical for B cell antigen receptor signaling.

1999 • 88 citations

Elevated content of phospholipase C-γ1 in colorectal cancer tissues

1994 • 88 citations

Multiple forms of phospholipase C isozymes and their activation mechanisms.

1992 • 88 citations

Phospholipase C Binds to the Receptor-like GPR1 Protein and Controls Pseudohyphal Differentiation in Saccharomyces cerevisiae

1999 • 87 citations

Phosphatidylinositol-specific phospholipase C from Bacillus cereus combines intrinsic phosphotransferase and cyclic phosphodiesterase activities: a phosphorus-31 NMR study

1990 • 84 citations

Gelsolin Binding to Phosphatidylinositol 4,5-Bisphosphate Is Modulated by Calcium and pH

1997 • 84 citations

Role of Phospholipase Cβ3 Phosphorylation in the Desensitization of Cellular Responses to Platelet-activating Factor

1997 • 83 citations

Pathway of phospholipase C activation initiated with platelet-derived growth factor is different from that initiated with vasopressin and bombesin.

1988 • 83 citations

Phospholipase C-148: Chromosomal Location and Deletion Mapping of Functional Domains

1988 • 81 citations

Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences.

1994 • 81 citations

Molecular cloning and expression of a phosphoinositide-specific phospholipase C of Dictyostelium discoideum.

1992 • 80 citations

Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma.

1996 • 80 citations

Identification of a Structural Element in Phospholipase C β2 That Interacts with G Protein βγ Subunits

1998 • 79 citations

Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis

1995 • 78 citations

Multiple roles for PI 3-kinase in the regulation of PLCγ activity and Ca2+ mobilization in antigen-stimulated mast cells

1999 • 78 citations

Activation of Phospholipase C δ1 through C2 Domain by a Ca2+-Enzyme-Phosphatidylserine Ternary Complex

1999 • 78 citations

Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.

1993 • 77 citations

Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo

1997 • 77 citations

Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells.

1998 • 76 citations

Localization of two forms of phospholipase C-β1, a and b, in C6Bu-1 cells

1998 • 76 citations

Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein.

1995 • 75 citations

Cloning and Identification of Amino Acid Residues of Human Phospholipase Cδ1 Essential for Catalysis

1995 • 74 citations

Localization of mRNAs for three novel members (β3, β4 and γ2) of phospholipase C family in mature rat brain

1994 • 73 citations

A heterotrimeric G protein complex couples the muscarinic m1 receptor to phospholipase C-beta.

1996 • 73 citations

Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres.

1992 • 72 citations

Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation.

1993 • 72 citations

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

1996 • 72 citations

AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana.

1997 • 71 citations

An SH3 domain is required for the mitogenic activity of microinjected phospholipase C‐γ1

1995 • 70 citations

Phosphoinositide Binding Specificity among Phospholipase C Isozymes as Determined by Photo-Cross-Linking to Novel Substrate and Product Analogs

1997 • 70 citations

Mechanism of Phosphatidylinositol-Specific Phospholipase C: A Unified View of the Mechanism of Catalysis^,

1998 • 70 citations

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

1990 • 69 citations

Epidermal Growth Factor Signaling and Mitogenesis inPlcg1Null Mouse Embryonic Fibroblasts

1998 • 69 citations

Effects of substitution of threonine 654 of the epidermal growth factor receptor on epidermal growth factor-mediated activation of phospholipase C.

1990 • 69 citations

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.

1991 • 69 citations

Epidermal growth factor induces rapid and transient association of phospholipase c-γ1 with egf-receptor and filamentous actin at membrane ruffles of a431 cells

1995 • 69 citations

Membrane Binding of Phospholipases C-β₁ and C-β₂ Is Independent of Phosphatidylinositol 4,5-Bisphosphate and the α and βγ Subunits of G Proteins

1996 • 68 citations

Phospholipase C-δ1 Contains a Functional Nuclear Export Signal Sequence

1999 • 68 citations

Rapid and Long Term Effects of Protein Kinase C on Receptor Tyrosine Kinase Phosphorylation and Degradation

1995 • 67 citations

Phospholipase C I and II brain isozymes: immunohistochemical localization in neuronal systems in rat brain.

1988 • 66 citations

Cutting Edge: Association of Phospholipase C-γ2 Src Homology 2 Domains with BLNK Is Critical for B Cell Antigen Receptor Signaling

1999 • 66 citations

The Role of the Pleckstrin Homology Domain in Membrane Targeting and Activation of Phospholipase Cβ1

2000 • 65 citations

D-myo-Inositol 1,4,5-Trisphosphate-Binding Proteins in Rat Brain Membranes1

1994 • 65 citations

Angiotensin II stimulation of Ca 2+ -channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002

1999 • 65 citations

Hormone and growth factor receptor-mediated regulation of phospholipase C activity

1989 • 64 citations

Characterization of Gq Family G Proteins GL1α (G14α), GL2α (G11α), and Gqα Expressed in the Baculovirus-Insect Cell System

1995 • 63 citations

Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1→S-phase progression

1997 • 63 citations

Scratching the surface with the PH domain

1995 • 62 citations

Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila.

1993 • 61 citations

Mutations within a highly conserved sequence present in the X region of phosphoinositide-specific phospholipase C-δ1

1995 • 60 citations

Selective interaction of the C2 domains of phospholipase C-β ₁ and -β ₂ with activated Gα _q subunits: An alternative function for C2-signaling modules

1999 • 60 citations

Phosphoinositide-specific phospholipase C-.delta.1: effect of monolayer surface pressure and electrostatic surface potentials on activity

1992 • 59 citations

A Novel, Phospholipase C-independent Pathway of Inositol 1,4,5-Trisphosphate Formation in Dictyostelium and Rat Liver

1995 • 59 citations

Phospholipase C Isozymes: Structural and Functional Similarities

2007 • 57 citations

Platelet-derived Growth Factor-dependent Cellular Transformation Requires Either Phospholipase Cγ or Phosphatidylinositol 3 Kinase

1997 • 57 citations

Catalysis by Phospholipase C δ₁ Requires That Ca²⁺ Bind to the Catalytic Domain, but Not the C2 Domain

1998 • 57 citations

Tissue-specific expression of phospholipase C encoded by the norpA gene of Drosophila melanogaster

1993 • 57 citations

Syk and Fyn Are Required by Mouse Megakaryocytes for the Rise in Intracellular Calcium Induced by a Collagen-related Peptide

1997 • 56 citations

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

1993 • 56 citations

An Essential Function of a Phosphoinositide-Specific Phospholipase C Is Relieved by Inhibition of a Cyclin-Dependent Protein Kinase in the Yeast Saccharomyces cerevisiae

1998 • 55 citations

Real-Time Visualization of PH Domain-Dependent Translocation of Phospholipase C-δ1 in Renal Epithelial Cells (MDCK): Response to Hypo-osmotic Stress

1999 • 55 citations

Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues

1993 • 54 citations

small wing encodes a phospholipase C-γ that acts as a negative regulator of R7 development in Drosophila

1998 • 53 citations

Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.

1994 • 53 citations

Phospholipase C cDNAs from sponge and hydra: antiquity of genes involved in the inositol phospholipid signaling pathway¹

1998 • 53 citations

Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C

1992 • 52 citations

Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.

1994 • 52 citations

Oxytocin receptor couples to the 80 kDa Gh alpha family protein in human myometrium.

1996 • 52 citations

Regulation of effectors by G-protein α- and βγ-Subunits

1997 • 50 citations

Cell Density Sensing Mediated by a G Protein-coupled Receptor Activating Phospholipase C

1998 • 50 citations

Purification and characterization of nuclear phospholipase C specific for phosphoinositides.

1994 • 50 citations

Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions

1997 • 49 citations

Bovine phospholipase C highly homologous to the norpA protein of Drosophila is expressed specifically in cones.

1994 • 49 citations

Targeted disruption of the mouse phospholipase C β3 gene results in early embryonic lethality

1998 • 49 citations

Intranuclear Translocation of Phospholipase C β2 during HL-60 Myeloid Differentiation

1997 • 48 citations

Structural Determinants for Interaction with Three Different Effectors on the G Protein β Subunit

1997 • 48 citations

Promiscuous Coupling of Receptors to Gq Class α Subunits and Effector Proteins in Pancreatic and Submandibular Gland Cells

1998 • 48 citations

A Novel Phospholipase C δ4 (PLCδ4) Splice Variant as a Negative Regulator of PLC

1999 • 48 citations

Lights out: deactivation of the phototransduction cascade

1997 • 47 citations

Phospholipids chiral at phosphorus. Stereochemical mechanism of reactions catalyzed by phosphatidylinositide-specific phospholipase C from Bacillus cereus and guinea pig uterus

1990 • 47 citations

Transduction of the chemotactic cAMP signal across the plasma membrane ofDictyostelium cells

1995 • 47 citations

A second gene product of the inositol‐phospholipid‐specific phospholipase Cδ subclass

1991 • 46 citations

Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans

1998 • 46 citations

Association of a receptor and G-protein-regulated phospholipase C with the cytoskeleton

1992 • 45 citations

Evidence that the Gh protein is a signal mediator from alpha 1-adrenoceptor to a phospholipase C. II. Purification and characterization of a Gh-coupled 69-kDa phospholipase C and reconstitution of alpha 1-adrenoceptor, Gh family, and phospholipase C.

1993 • 44 citations

Src Homology Domains of Phospholipase C γ1 Inhibit Nerve Growth Factor‐Induced Differentiation of PC12 Cells

1998 • 44 citations

Transforming potentials of epidermal growth factor and nerve growth factor receptors inversely correlate with their phospholipase C gamma affinity and signal activation.

1996 • 43 citations

Deletion and Site-Directed Mutagenesis of EF-Hand Domain of Phospholipase C-δ1: Effects on Its Activity

1995 • 43 citations

G-protein βγ subunits antagonize protein kinase C-dependent phosphorylation and inhibition of phospholipase C-β1

1997 • 42 citations

CDC25‐dependent induction of inositol 1,4,5‐trisphosphate and diacylglycerol in Saccharomyces cerevisiae by nitrogen

1992 • 41 citations

Oxytocin receptor couples to the 80 kDa Ghα family protein in human myometrium

1996 • 41 citations

Angiotensin II activates the beta 1 isoform of phospholipase C in vascular smooth muscle cells

1997 • 40 citations

[48] Assays of phosphoinositide-specific phospholipase C and purification of isozymes from bovine brains

1991 • 40 citations

Phospholipase C isozymes in neurons and glial cells in culture: an immunocytochemical and immunochemical study

1991 • 40 citations

Protein Kinase C Inhibits Epidermal Growth Factor-Dependent Tyrosine Phosphorylation of Phospholipase Cγ and Activation of Phosphoinositide Hydrolysis*†

1990 • 39 citations

The rat phospholipase Cβ 4 gene is expressed at high abundance in cerebellar Purkinje cells

1995 • 38 citations

Phosphoinositide-Specific Phospholipase C δ1 Activity toward Micellar Substrates, Inositol 1,2-Cyclic Phosphate, and Other Water-Soluble Substrates: A Sequential Mechanism and Allosteric Activation

1997 • 38 citations

Membrane-binding properties of phospholipase C-β1 and phospholipaseC-β2: role of the C-terminus and effects of polyphosphoinositides, G-proteins and Ca2+

1997 • 37 citations

Phosphorylation of Phospholipase Cγ1 on Tyrosine Residue 783 by Platelet-Derived Growth Factor Regulates Reorganization of the Cytoskeleton

1998 • 36 citations

Cyclic and noncyclic inositol phosphates are formed at different ratios by phospholipase C isozymes

1989 • 36 citations

Changes of Nuclear PI-PLC γ1 During Rat Liver Regeneration

1997 • 36 citations

Formation of Signal Transfer Complexes between Stem Cell and Platelet-Derived Growth Factor Receptors and SH2 Domain Proteins in Vitro

1995 • 36 citations

Phospholipase Cγ Activation, Phosphotidylinositol Hydrolysis, and Calcium Mobilization are Not Required for FGF Receptor-Mediated Chemotaxis

1994 • 36 citations

Phosphorylation by protein kinase C decreases catalytic activity of avian phospholipase C-β

1999 • 35 citations

Immunohistochemical localization of a brain isozyme of phospholipase C (PLC III) in astroglia in rat brain

1989 • 35 citations

Immunohistochemical distribution of neurons containing the G-proteins Gqα/G11α in the adult rat brain

1992 • 35 citations

Multiple Subtypes of Phospholipase C Are Encoded by the norpA Gene of Drosophila melanogaster

1995 • 34 citations

Phosphatidylinositol 3,4,5-Trisphosphate Triggers Platelet Aggregation by Activating Ca²⁺ Influx

1998 • 34 citations

A Cytosolic, Gαq- and βγ-insensitive Splice Variant of Phospholipase C-β4

1998 • 34 citations

PLCγ1 Src Homology Domain Induces Mitogenesis in Quiescent NIH 3T3 Fibroblasts

1996 • 33 citations

[Hydrolysis of porcine pepsin peptides by crystalline lens leucine aminopeptidase].

1971 • 33 citations

Binding of phospholipase Cδ1 to phospholipid vesicles

1993 • 32 citations

Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity

1998 • 32 citations

A 50 kDa Protein Modulates Guanine Nucleotide Binding of Transglutaminase II

1996 • 31 citations

Phosphorylation of Phospholipase Cγ1 and Its Association with the FGF Receptor is Developmentally Regulated and Occurs during Mesoderm Induction in Xenopus laevis

1994 • 30 citations

Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells

1998 • 30 citations

Dependence of the Activity of Phospholipase Cβ on Surface Pressure and Surface Composition in Phospholipid Monolayers and Its Implications for Their Regulation

1997 • 30 citations

Localization of phospholipase C δ3 in the cell and regulation of its activity by phospholipids and calcium

1998 • 29 citations

Purification of a novel phospholipase C isozyme from bovine cerebellum

1993 • 29 citations

Isolation and characterization of temperature-sensitiveplc1 mutants of the yeastSaccharomyces cerevisiae

1995 • 28 citations

cDNA Sequence and Gene Locus of the Human Retinal Phosphoinositide-Specific Phospholipase-Cβ4 (PLCB4)

1995 • 28 citations

Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-γ1

1998 • 28 citations

Action of Phosphatidylinositol-specific Phospholipase Cγ1 on Soluble and Micellar Substrates

1999 • 27 citations

Overexpression of Phospholipase C-γ1 in Colorectal Carcinomas Is Associated with Overexpression of Factors That Bind Its Promoter

1995 • 27 citations

The Arabidopsis thaliana genome has multiple divergent forms of phosphoinositol-specific phospholipase C

1997 • 26 citations

Differential Requirement of a Motif within the Carboxyl-terminal Domain of α-Platelet-derived Growth Factor (αPDGF) Receptor for PDGF Focus Forming Activity Chemotaxis, or Growth

1995 • 26 citations

Intracellular distribution of phospholipase C gamma 1 in cell lines with different levels of transformation.

1997 • 26 citations

Developmental changes of three phosphoinositide-specific phospholipase C isozymes in the rat nervous system

1991 • 25 citations

Molecular cloning of the plc1⁺ gene of Schizosaccharomyces pombe, which encodes a putative phosphoinositide‐specific phospholipase C

1995 • 25 citations

Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by G_q

1992 • 24 citations

Mutation of an EF-hand Ca2+-binding motif in phospholipase C of Dictyostelium discoideum: inhibition of activity but no effect on Ca2+-dependence

1995 • 24 citations

A New Function for Phospholipase C-γ1: Coupling to the Adaptor Protein GRB2

1997 • 23 citations

Expression of phospholipase C-gamma 1 and its transcriptional regulators in breast cancer tissues.

1998 • 22 citations

Stimulation of G‐protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C γ‐1

1998 • 22 citations

Molecular cloning, expression and regulatory activity of Gα11- and βγ-subunit-stimulated phospholipase C-β from avian erythrocytes

1996 • 22 citations

Phosphoinositide-specific phospholipase C forms a complex with 14-3-3 proteins and is involved in expression of UV resistance in fission yeast

1998 • 22 citations

Phospholipase‐C‐Independent Inositol 1,4,5‐Trisphosphate Formation in Dictyostelium Cells — Activation of a Plasma‐Membrane‐Bound Phosphatase by Receptor‐Stimulated Ca²⁺ Influx

1997 • 22 citations

Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in N1E-115 neuroblastoma cells: involvement of Rho proteins.

1996 • 21 citations

Activation of a phospholipase Cβ2 deletion mutant by limited proteolysis

1998 • 21 citations

Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages.

1994 • 20 citations

Regulation of phospholipase C-delta by GTP-binding proteins-rhoA as an inhibitory modulator

1998 • 20 citations

Purification and G Protein Subunit Regulation of a Phospholipase C-β from Xenopus laevis Oocytes

1996 • 20 citations

Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH‐3T3 fibroblasts

1995 • 20 citations

Novel bimodal effects of the G-protein tissue transglutaminase on adrenoreceptor signalling

1999 • 19 citations

Phospholipase C Isoforms δ1and δ3from Human Fibroblasts

1997 • 19 citations

Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors

1997 • 19 citations

Genomic structure of the human PLCD1 (phospholipase C delta 1) locus on 3p22→p21.3

1997 • 18 citations

Characterization of the Apolipoprotein(a) Gene

1995 • 18 citations

Growth of a mutant defective in a putative phosphoinositide-specific phospholipase C of Schizosaccharomyces pombe is restored by low concentrations of phosphate and inositol

1995 • 17 citations

Down‐regulation of phospholipase C‐γ1 during the differentiation of U937 cells

1995 • 16 citations

Transcriptional Regulation of Phospholipase C-γ1 Gene during Muscle Differentiation

1995 • 15 citations

Inhibition of Phosphoinositide Hydrolysis and Cell Growth of Swiss 3T3 Cells by Myristoylated Phospholipase C Inhibitor Peptides

1997 • 15 citations

Epidermal growth factor activates phospholipase C-gamma 1 via G(i)1-2 proteins in isolated pancreatic acinar membranes

1997 • 15 citations

Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex

1996 • 14 citations

[22] Phosphatidylinositol 4-kinases and phosphatidylinositol-4-phosphate 5-kinases from bovine brain brain membranes

1992 • 14 citations

Positive Charge at Position 549 Is Essential for Phosphatidylinositol 4,5-Bisphosphate-hydrolyzing but Not Phosphatidylinositol-hydrolyzing Activities of Human Phospholipase C δ1

1996 • 14 citations

Identification of Putative Phosphoinositide-specific Phospholipase C Genes in Filamentous Fungi

1997 • 12 citations

A G‐protein‐coupled 130 kDa phospholipase C isozyme, PLC‐β4, from the particulate fraction of bovine cerebellum

1993 • 11 citations

Phosphatidylinositol transfer proteins: an essential requirement in inositol lipid signalling

1997 • 11 citations

Effects of ionizing irradiation on endothelial cell transglutaminase

1993 • 10 citations

Mutations at residues Tyr⁷⁷¹ and Tyr⁷⁸³ of phospholipase C‐γ1 have different effects on cell actin‐cytoskeleton organization and cell proliferation in CCL‐39 cells

1998 • 10 citations

Reduction in Gh protein expression is associated with cytodifferentiation of vascular smooth muscle cells

1996 • 9 citations

Selectivity of phospholipase C isozymes in growth factor signaling

1993 • 9 citations

Nuclear apoptosis induced by isolated mitochondria

2000 • 8 citations

Phosphatidylinositol-Specific Phospholipase C. 3. Elucidation of the Catalytic Mechanism and Comparison with Ribonuclease A¹

1997 • 7 citations

[18] Characterization of phospholipase C isozymes in bovine retina: Purification of phospholipase C-β4

1994 • 4 citations

The Promoter Activity of the Phospholipase C-γ2 Gene Is Regulated by a Cell-Type-Specific Control Element

1997 • 4 citations

The activity of a phospholipase Cβ assayed using phospholipid monolayers

1993 • 3 citations

Characterisation of a phospholipase Cδ from Schizosaccharomyces pombe

1997 • 2 citations