Differential Regulation of Muscarinic Acetylcholine Receptor-sensitive Polyphosphoinositide Pools and Consequences for Signaling in Human Neuroblastoma Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Phosphoinositide kinases

1996 • 529 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

1997 • 435 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains

1996 • 354 citations

A wortmannin-sensitive phosphatidylinositol 4-kinase that regulates hormone-sensitive pools of inositolphospholipids.

1995 • 349 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D.

1994 • 277 citations

Purification and characterization of two G-proteins that activate the beta 1 isozyme of phosphoinositide-specific phospholipase C. Identification as members of the Gq class.

1991 • 191 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase

1997 • 171 citations

Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells.

1992 • 166 citations

Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y

1990 • 151 citations

Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay

1990 • 150 citations

Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells.

1992 • 132 citations

Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1

1989 • 123 citations

Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland

1986 • 121 citations

Characterization of a Soluble Adrenal Phosphatidylinositol 4-Kinase Reveals Wortmannin Sensitivity of Type III Phosphatidylinositol Kinases

1996 • 119 citations

The interaction of lithium with thyrotropin-releasing hormone-stimulated lipid metabolism in GH3 pituitary tumour cells. Enhancement of stimulated 1,2-diacylglycerol formation

1984 • 116 citations

Cloning, Expression, and Localization of 230-kDa Phosphatidylinositol 4-Kinase

1996 • 114 citations

Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells.

1992 • 113 citations

Desensitization of cell signalling mediated by phosphoinositidase C

1993 • 112 citations

The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell.

1986 • 98 citations

Muscarinic Receptor‐Mediated Inositol 1,4,5‐Trisphosphate Formation in SH‐SY5Y Neuroblastoma Cells Is Regulated Acutely by Cytosolic Ca²⁺ and by Rapid Desensitization

1994 • 88 citations

Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle

1991 • 85 citations

Chemical ‘snapshots’ of DNA: using the hydroxyl radical to study the structure of DNA and DNA-protein complexes

1987 • 85 citations

Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+.

1992 • 80 citations

Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis

1995 • 78 citations

The use of the human neuroblastoma SH-SY5Y to study the effect of second messengers on noradrenaline release

1995 • 70 citations

Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin.

1994 • 59 citations

Regulation of Brain Phosphatidylinositol-4-phosphate Kinase by GTP Analogues

1989 • 59 citations

Quantitative comparisons of muscarinic and bradykinin receptor‐mediated Ins (1,4,5)P₃ accumulation and Ca²⁺ signalling in human neuroblastoma cells

1995 • 56 citations

Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues

1993 • 54 citations

Synthesis of phosphatidylinositol 4,5-bisphosphate in the endoplasmic reticulum of Chinese hamster ovary cells.

1991 • 45 citations

Disruption by lithium of phosphatidylinositol-4,5-bisphosphate supply and inositol-1,4,5-trisphosphate generation in Chinese hamster ovary cells expressing human recombinant m1 muscarinic receptors.

1994 • 40 citations

Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells

1996 • 34 citations

m3 Muscarinic receptor-induced and Gi-mediated heterologous potentiation of phospholipase C stimulation: role of phosphoinositide synthesis.

1996 • 31 citations

Lithium Enhances Muscarinic Receptor–Stimulated CDP‐Diacylglycerol Formation in Inositol‐Depleted SK‐N‐SH Neuroblastoma Cells

1993 • 30 citations

Heterologous desensitization of both phosphoinositide and Ca2+ signaling in SH-SY5Y neuroblastoma cells: a role for intracellular Ca2+ store depletion?

1995 • 29 citations

Protein kinase C-mediated formation of phosphatidylinositol 3,4-bisphosphate in human platelets

1990 • 25 citations

A rapid attenuation of muscarinic agonist stimulated phosphoinositide hydrolysis precedes receptor sequestration in human SH-SY-5Y neuroblastoma cells

1994 • 23 citations

Inhibition by toxin B of inositol phosphate formation induced by G protein-coupled and tyrosine kinase receptors in N1E-115 neuroblastoma cells: involvement of Rho proteins.

1996 • 21 citations

Regulation of phosphatidylinositol 4-kinase activity in rat pancreatic acini.

1993 • 8 citations