Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Protein modules and signalling networks

1995 • 2,447 citations

Measurement of protein-binding phenomena by gel filtration

1962 • 1,275 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Cloning and sequence of multiple forms of phospholipase C

1988 • 342 citations

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.

1994 • 322 citations

PH domain: the first anniversary

1994 • 318 citations

Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin

1994 • 268 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Structure of the pleckstrin homology domain from β-spectrin

1994 • 233 citations

Solution structure of a pleckstrin-homology domain

1994 • 211 citations

Proteolytic fragments of phosphoinositide-specific phospholipase C-delta 1. Catalytic and membrane binding properties

1993 • 160 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1.

1994 • 141 citations

Putative inositol 1,4,5-trisphosphate binding proteins in rat brain cytosol.

1992 • 139 citations

Phospholipase A₂ at the bilayer interface

1991 • 138 citations

Crystal structure of the pleckstrin homology domain from dynamin

1994 • 120 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

Identification of Novel Pleckstrin Homology (PH) Domains Provides a Hypothesis for PH Domain Function

1993 • 99 citations

The electrostatic basis for the interfacial binding of secretory phospholipases A2

1994 • 93 citations

Three-dimensional solution structure of the pleckstrin homology domain from dynamin

1994 • 92 citations

Binding of PH Domains of β-Adrenergic-Receptor Kinase and β-Spectrin to WD40/β-Transducin Repeat Containing Regions of the β-Subunit of Trimeric G-Proteins

1994 • 90 citations

Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy.

1995 • 88 citations

Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2).

1994 • 73 citations

PH domains and phospholipases — a meaningful relationship?

1994 • 72 citations

Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes.

1994 • 72 citations

Thermodynamic Studies of Tyrosyl-Phosphopeptide Binding to the SH2 Domain of p56lck

1994 • 53 citations

D-myo-Inositol 1,4,5-Trisphosphate Binding Domain of Phospholipase C-δ1

1994 • 26 citations