G protein-linked signaling pathways control the developmental program of dictyostelium

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Tagging developmental genes in Dictyostelium by restriction enzyme-mediated integration of plasmid DNA.

1992 • 484 citations

A Chemoattractant Receptor Controls Development in Dictyostelium discoideum

1988 • 465 citations

Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits

1992 • 441 citations

Dictyostelium discoideum : a Model System for Cell-Cell Interactions in Development

1989 • 342 citations

Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development

1992 • 307 citations

Regulation and function of Gα protein subunits in Dictyostelium

1989 • 227 citations

Chemoattractant-elicited increases in myosin phosphorylation in dictyostelium

1985 • 173 citations

Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response.

1979 • 169 citations

Streamers: Chemotactic Mutants of Dictyostelium discoideum with Altered Cyclic GMP Metabolism

1981 • 168 citations

Culmination in dictyostelium is regulated by the cAMP-dependent protein kinase

1992 • 148 citations

Gene targeting of the aggregation stage cAMP receptor cAR1 in Dictyostelium.

1991 • 148 citations

A G-protein beta-subunit is essential for Dictyostelium development.

1993 • 147 citations

Surface receptor-mediated activation of adenylate cyclase in Dictyostelium. Regulation by guanine nucleotides in wild-type cells and aggregation deficient mutants.

1986 • 144 citations

Cloning and cDNA sequence of the regulatory subunit of cAMP-dependent protein kinase from Dictyostelium discoideum.

1987 • 136 citations

CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.

1993 • 136 citations

Signal transduction in Dictyostelium fgd A mutants with a defective interaction between surface cAMP receptors and a GTP-binding regulatory protein [published erratum appears in J Cell Biol 1988 Dec;107(6 Pt 1):following 2463]

1988 • 124 citations

Excitation, adaption, and deadaptation of the cAMP-mediated cGMP Response in dictyostelium discoideum

1983 • 121 citations

DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase.

1992 • 108 citations

Overexpression of Dd PK2 protein kinase causes rapid development and affects the intracellular cAMP pathway of Dictyostelium discoideum

1992 • 100 citations

Ligand-induced phosphorylation of the cAMP receptor from Dictyostelium discoideum.

1988 • 99 citations

Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development.

1993 • 98 citations

A Ca2+ transport system associated with the plasma membrane of Dictyostelium discoideum is activated by different chemoattractant receptors.

1991 • 94 citations

Molecular cloning and expression of a phosphoinositide-specific phospholipase C of Dictyostelium discoideum.

1992 • 80 citations

The cyclic nucleotide phosphodiesterase gene of Dictyostelium discoideum contains three promoters specific for growth, aggregation, and late development.

1990 • 79 citations

Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA).

1993 • 77 citations

Isolation and characterization of cAMP unresponsive (frigid) aggregation‐deficient mutants of Dictyostelium discoideum

1982 • 71 citations

Dictyostelium transiently expresses eight distinct G-protein α-subunits during its developmental program

1991 • 68 citations

A role for cAMP-dependent protein kinase A in early Dictyostelium development.

1990 • 64 citations

The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in Dictyostelium discoideum by a G alpha 2-independent mechanism.

1993 • 64 citations

Identification of Dictyostelium G alpha genes expressed during multicellular development.

1991 • 64 citations

Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium.

1992 • 60 citations

In Vivo Receptor-Mediated Phosphorylation of a G Protein in Dictyostelium

1990 • 55 citations

Localization of ligand-induced phosphorylation sites to serine clusters in the C-terminal domain of the Dictyostelium cAMP receptor, cAR1.

1994 • 53 citations

Overexpression of the cAMP receptor 1 in growing Dictyostelium cells

1991 • 49 citations

Transduction of the chemotactic signal to the actin cytoskeleton of Dictyostelium discoideum

1989 • 45 citations

The possible involvement of oscillatory cAMP signaling in multicellular morphogenesis of the cellular slime molds

1984 • 44 citations

Signal transduction: Prokaryotic and simple eukaryotic systems

1994 • 39 citations

cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels.

1992 • 35 citations

Agonist‐stimulated high‐affinity GTPase in Dictyostelium membranes

1988 • 25 citations

Pertussis toxin inhibits cAMP surface receptor‐stimulated binding of [³⁵S]GTPγS to Dictyostelium discoideum membranes

1988 • 23 citations

Cell—Cell Interactions in the Development of Dictyostelium

1986 • 14 citations

Dynamics and function of the inositolcycle in Dictyostelium discoideum

1991 • 8 citations

Extracellular signals and intracellular transduction pathways regulating Dictyostelium development

1989 • 7 citations

Biochemistry and Genetics of Sensory Transduction in Dictyostelium

1993 • 5 citations