Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Nerve growth factor.

1968 • 2,025 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Epidermal Growth Factor and a New Derivative

1972 • 1,225 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

THE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN

1969 • 920 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

1989 • 671 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Acid and base hydrolysis of phosphoproteins bound to Immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins

1989 • 469 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Nerve growth factor-induced increase in electrical excitability and acetylcholine sensitivity of a rat pheochromocytoma cell line

1977 • 395 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.

1989 • 262 citations

Nerve growth factor-induced alteration in the response of PC12 pheochromocytoma cells to epidermal growth factor

1981 • 262 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states.

1980 • 255 citations

Synthesis, storage and release of acetylcholine by a noradrenergic pheochromocytoma cell line

1977 • 252 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells.

1985 • 218 citations

Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.

1986 • 197 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor.

1980 • 132 citations

Calcium-Dependent Nerve Growth Factor-Stimulated Hydrolysis of Phosphoinositides in PC12 Cells

1987 • 127 citations

Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.

1985 • 124 citations

Alterations of Lipid Metabolism in Response to Nerve Growth Factor

1982 • 97 citations

Nerve growth factor-induced increase in the cell-free phosphorylation of a nuclear protein in PC12 cells.

1985 • 92 citations

Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cells.

1987 • 88 citations

Tyrosine phosphorylated proteins in different tissues during chick embryo development.

1988 • 85 citations

Production of 1,2‐Diacylglycerol in PC12 Cells by Nerve Growth Factor and Basic Fibroblast Growth Factor

1990 • 57 citations

Nerve growth factor-induced decrease in the cell-free phosphorylation of a soluble protein in PC12 cells.

1983 • 56 citations

Role of protein tyrosine phosphorylation in the NGF response

1989 • 52 citations