Somatostatin Receptor-mediated Signaling in Smooth Muscle

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents

1991 • 576 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Molecular biology of opioid receptors

1993 • 358 citations

The somatostatin receptor family

1995 • 356 citations

Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase.

1992 • 313 citations

Molecular biology of somatostatin receptors

1993 • 311 citations

Activation of phospholipase C isozymes by G protein beta gamma subunits.

1993 • 306 citations

Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.

1995 • 300 citations

Molecular cloning and functional expression of a brain-specific somatostatin receptor.

1992 • 299 citations

Somatostatin stimulates Ca2+-activated K+ channels through protein dephosphorylation

1991 • 261 citations

Tissue distribution of somatostatin receptor subtype messenger ribonucleic acid in the rat.

1993 • 250 citations

All Five Cloned Human Somatostatin Receptors (hSSTR1-5) Are Functionally Coupled to Adenylyl Cyclase

1994 • 239 citations

Molecular pharmacology of somatostatin receptors

1994 • 216 citations

Beta gamma-subunit activation of G-protein-regulated phospholipase C.

1992 • 197 citations

Na(+)-H+ exchanger subtypes: a predictive review

1991 • 144 citations

Pharmacological properties of two cloned somatostatin receptors.

1992 • 133 citations

Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide-dependent activation of membrane-bound NO synthase in smooth muscle mediated by pertussis toxin-sensitive Gi1-2.

1994 • 112 citations

Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.

1994 • 103 citations

Cloning and expression of a rat somatostatin receptor enriched in brain.

1992 • 101 citations

Phospholipase C activation and Ca²⁺ mobilization by cloned human somatostatin receptor subtypes 1–5, in transfected COS‐7 cells

1994 • 95 citations

Functional characterization of phosphoinositide-specific phospholipase C-beta 1 and -beta 3 in intestinal smooth muscle

1995 • 88 citations

Somatostatin activates an inwardly rectifying K+ conductance in freshly dispersed rat somatotrophs.

1991 • 76 citations

Adenosine A1 receptor-mediated activation of phospholipase C-beta 3 in intestinal muscle: dual requirement for alpha and beta gamma subunits of Gi3.

1995 • 75 citations

Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine

1994 • 68 citations

Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.

1992 • 58 citations

Transfected Human Somatostatin Receptor Type 2, SSTR2, Not Only Inhibits Adenylate Cyclase but Also Stimulates Phospholipase C and Ca2+ Mobilization

1994 • 55 citations

Potent Inhibitory Effects of a Type Four Receptor-Selective Somatostatin Analog on Rat Insulin Release

1993 • 53 citations

On the Mechanism of Cytosolic Phospholipase A2 Activation in CHO Cells Carrying Somatostatin Receptor: Wortmannin-Sensitive Pathway to Activate Mitogen-Activated Protein Kinase

1994 • 52 citations

Somatostatin receptor activation of cellular effector systems

1995 • 51 citations

Adenosine A1 and A2b receptors coupled to distinct interactive signaling pathways in intestinal muscle cells.

1995 • 50 citations

Measurement of GTPγS binding to specific G proteins in membranes using G-protein antibodies

1992 • 43 citations

Identification and quantification of Gi-type GTP-binding proteins that copurify with a pituitary somatostatin receptor.

1993 • 42 citations

Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.

1994 • 36 citations

Muscarinic Receptors Stimulate Ca2+ Influx via Phospholipase A2 Pathway in Ileal Smooth Muscles

1993 • 29 citations

Multiple Effector Coupling of Somatostatin Receptor Subtype SSTR1

1994 • 29 citations

Rat somatostatin receptor type 1 couples to G proteins and inhibition of cyclic AMP accumulation.

1994 • 22 citations

Somatostatin induces release of the α subunits of pertussis toxin-sensitive G proteins in native membranes and in intact GH4 C1 rat pituitary cells

1993 • 7 citations