Angiotensin II Signal Transduction in Vascular Smooth Muscle

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 • 1,473 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

1994 • 1,012 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

The Primary Structure of MEK, a Protein Kinase that Phosphorylates the ERK Gene Product

1992 • 931 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors.

1993 • 767 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

1991 • 708 citations

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

1995 • 704 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Signaling by the cytokine receptor superfamily: JAKs and STATs

1994 • 659 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

1989 • 558 citations

The when and how of Src regulation

1993 • 543 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

The ins and outs of Raf kinases

1994 • 537 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.

1986 • 491 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Angiotensin II Induces c-fos mRNA in Aortic Smooth Muscle

1989 • 401 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Occupation of the c-fos serum response element in vivo by a multi-protein complex is unaltered by growth factor induction

1989 • 346 citations

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase.

1993 • 345 citations

Interaction of Shc with the ζ Chain of the T Cell Receptor Upon T Cell Activation

1993 • 343 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

Induction by EGF and Interferon-γ of Tyrosine Phosphorylated DNA Binding Proteins in Mouse Liver Nuclei

1993 • 285 citations

Signal transduction through integrins: A central role for focal adhesion kinase?

1995 • 273 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

Angiotensin II stimulation of rapid protein tyrosine phosphorylation and protein kinase activation in rat aortic smooth muscle cells.

1993 • 251 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide

1994 • 239 citations

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

1994 • 230 citations

Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor

1996 • 230 citations

Activators and effectors of ras p21 proteins

1994 • 228 citations

Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.

1987 • 228 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

Protein Kinase C-ζ Mediates Angiotensin II Activation of ERK1/2 in Vascular Smooth Muscle Cells

1997 • 220 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

1992 • 210 citations

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.

1994 • 204 citations

Characterization of Gas6, a Member of the Superfamily of G Domain-containing Proteins, as a Ligand for Rse and Axl

1996 • 195 citations

Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.

1991 • 195 citations

Identification of Gas6 as a growth factor for human Schwann cells

1996 • 190 citations

Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

1994 • 186 citations

Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor.

1994 • 186 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Vascular Smooth Muscle Cell-derived, Gla-containing Growth-potentiating Factor for Ca2+-mobilizing Growth Factors

1995 • 180 citations

Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells

1995 • 177 citations

Electroporation of pp60c− Antibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 175 citations

Tetrazole and Carboxylate Groups of Angiotensin Receptor Antagonists Bind to the Same Subsite by Different Mechanisms

1995 • 172 citations

Tyrosine kinase pathways and the regulation of smooth muscle contractility

1994 • 168 citations

Identification of peptide binding residues in the extracellular domains of the AT1 receptor.

1994 • 168 citations

Angiotensin II Activates pp60 ^{c- src} in Vascular Smooth Muscle Cells

1995 • 167 citations

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

1993 • 162 citations

Differential Activation of the Ras/Extracellular-Signal-Regulated Protein Kinase Pathway Is Responsible for the Biological Consequences Induced by the Axl Receptor Tyrosine Kinase

1996 • 162 citations

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

1993 • 159 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

Immunohistochemical localization of rat angiotensin II AT1 receptor

1993 • 151 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 143 citations

Angiotensin II Controls p21 Activity via pp60

1996 • 138 citations

THE PURIFICATION OF HYPERTENSIN I

1954 • 137 citations

Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

1994 • 136 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

Angiotensin increases cytosolic free calcium in cultured vascular smooth muscle cells.

1985 • 135 citations

Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis

1992 • 134 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Convergent signalling in the action of integrins, neuropeptides, growth factors and oncogenes.

1995 • 132 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.

1994 • 130 citations

Domains for G-protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis

1992 • 129 citations

Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells

1995 • 129 citations

Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.

1993 • 128 citations

Angiotensin II stimulates two myelin basic protein/microtubule-associated protein 2 kinases in cultured vascular smooth muscle cells.

1992 • 128 citations

Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan

1994 • 127 citations

A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

1995 • 127 citations

Cloning of cDNA and Analysis of the Gene for Mouse Angiotensin II Type 2 Receptor

1993 • 127 citations

Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor

1995 • 122 citations

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1994 • 122 citations

G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.

1995 • 122 citations

Signaling by the Cytokine Receptor Superfamily^a

1998 • 119 citations

Mutagenesis and the Molecular Modeling of the Rat Angiotensin II Receptor (AT1)

1995 • 118 citations

Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner.

1990 • 118 citations

Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.

1994 • 117 citations

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.

1994 • 115 citations

Sperm-specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91-base-pair promoter containing a CRE-like element.

1993 • 115 citations

Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells

1987 • 114 citations

Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.

1976 • 111 citations

Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells

1993 • 99 citations

Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C.

1994 • 97 citations

Angiotensin II stimulation of rapid paxillin tyrosine phosphorylation correlates with the formation of focal adhesions in rat aortic smooth muscle cells

1995 • 97 citations

Angiotensin II Stimulates Tyrosine Phosphorylation of the Focal Adhesion-associated Protein Paxillin in Aortic Smooth Muscle Cells

1995 • 94 citations

Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II.

1992 • 94 citations

In Vitro Tyrosine Phosphorylation of PLC-γ1 and PLC-γ2 by SRC-Family Protein Tyrosine Kinases

1993 • 89 citations

Mapping of G Protein Coupling Sites of the Angiotensin II Type 1 Receptor

1995 • 87 citations

The tyrosine within the NPXnY motif of the human angiotensin II type 1 receptor is involved in mediating signal transduction but is not essential for internalization.

1996 • 84 citations

Protein synthesis, cell growth and oncogenesis

1991 • 82 citations

Ca ²⁺ -Dependent Mitogen-Activated Protein Kinase Activation in Spontaneously Hypertensive Rat Vascular Smooth Muscle Defines a Hypertensive Signal Transduction Phenotype

1996 • 78 citations

The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine Kinases

1994 • 77 citations

Mitogenic Signals and Transforming Potential of Nyk, a Newly Identified Neural Cell Adhesion Molecule-Related Receptor Tyrosine Kinase

1995 • 77 citations

G-Protein-coupled Receptors: Regulatory Role of Receptor Kinases and Arrestin Proteins

1992 • 74 citations

Angiotensin II Stimulation of Vascular Smooth Muscle

1989 • 74 citations

Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.

1995 • 74 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-alpha and -beta in vascular smooth muscle cells.

1994 • 71 citations

Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats.

1992 • 67 citations

Angiotensin II Stimulates MAP Kinase Kinase Kinase Activity in Vascular Smooth Muscle Cells

1996 • 67 citations

Electrotransjection of pp60v-src monoclonal antibody inhibits activation of phospholipase C in platelets. A new mechanism for platelet-activating factor responses.

1994 • 67 citations

Critical Role of a Conserved Intramembrane Tyrosine Residue in Angiotensin II Receptor Activation

1995 • 64 citations

Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor.

1994 • 63 citations

Evidence for involvement of phospholipase C-γ2 in signal transduction of platelet-derived growth factor in vascular smooth-muscle cells

1993 • 56 citations

Phosphorylation of JAK2 in thrombin‐stimulated human platelets

1994 • 53 citations

Unphosphorylated and tyrosine‐phosphorylated forms of a focal adhesion protein, paxillin, are substrates for calpain II in vitro: Implications for the possible involvement of calpain II in mitosis‐specific degradation of paxillin

1994 • 49 citations

Angiotensin II Stimulation of Vascular Smooth Muscle Cells: Secondary Signalling Mechanisms

1989 • 46 citations

Involvement of a tyrosine kinase pathway in the growth-promoting effects of angiotensin II on aortic smooth muscle cells.

1995 • 45 citations

Effects of angiotensin II and of phorbol ester on protein kinase C activity and on prostacyclin production in cultured rat aortic smooth-muscle cells

1989 • 44 citations

Angiotensin II stimulates phosphorylation of nuclear lamins via a protein kinase C-dependent mechanism in cultured vascular smooth muscle cells.

1990 • 44 citations

The role of tyrosine phosphorylation in angiotensin II-mediated intracellular signalling

1995 • 41 citations

Angiotensin II transduces its signal to focal adhesions via angiotensin II type 1 receptors in vascular smooth muscle cells

1995 • 40 citations

Involvement of MAP kinase activators in angiotensin II‐induced activation of MAP kinases in cultured vascular smooth muscle cells

1992 • 37 citations

Deglycosylation and fragmentation of purified rat liver angiotensin II receptor: application to the mapping of hormone-binding domains

1993 • 37 citations

Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells.

1994 • 37 citations

Angiotensin II Mediates Intracellular Signaling in Vascular Smooth Muscle Cells by Activation of Tyrosine-Specific Protein Kinases and c-raf-1

1993 • 30 citations

Activation of S6 kinase in cultured vascular smooth muscle cells by submitogenic levels of thrombospondin

1988 • 28 citations

Sequence of a cDNA encoding dog insulin-like growth factor I

1993 • 25 citations

Angiotensin-ll-and Endothelin-lnduced Protein Phosphorylation in Cultured Vascular Smooth Muscle Cells

1993 • 14 citations

Structure and Regulated Expression of Angiotensin-Converting Enzyme and the Receptor for Angiotensin II

1993 • 10 citations

Molecular analysis of the renin-angiotensin system.

1992 • 4 citations