Analysis of Platelet-derived Growth Factor-induced Phospholipase D Activation in Mouse Embryo Fibroblasts Lacking Phospholipase C-γ1

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Phosphatidylcholine breakdown and signal transduction

1994 • 955 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

1987 • 670 citations

Signal Transduction by the Platelet-Derived Growth Factor Receptor

1989 • 653 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Interleukin-1 stimulates diacylglycerol production in T lymphocytes by a novel mechanism

1988 • 413 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement.

1994 • 333 citations

New Developments in Phospholipase D

1997 • 313 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors

1995 • 267 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

1992 • 231 citations

Stimulation of actin stress fibre formation mediated by activation of phospholipase D

1996 • 215 citations

Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation

1991 • 196 citations

Phospholipase D

1978 • 190 citations

Differential translocation of protein kinase C isozymes by thrombin and platelet-derived growth factor. A possible function for phosphatidylcholine-derived diacylglycerol

1993 • 182 citations

Activation of actin polymerization by phosphatidic acid derived from phosphatidylcholine in IIC9 fibroblasts.

1993 • 175 citations

Receptor tyrosine kinase substrates: src homology domains and signal transduction

1992 • 156 citations

Stimulation of Phospholipase D by Epidermal Growth Factor Requires Protein Kinase C Activation in Swiss 3T3 Cells

1995 • 143 citations

Protein kinase C alpha mediates phospholipase D activation by nucleotides and phorbol ester in Madin-Darby canine kidney cells. Stimulation of phospholipase D is independent of activation of polyphosphoinositide-specific phospholipase C and phospholipase A2.

1994 • 133 citations

Divergence in Signal Transduction Pathways of Platelet-derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) Receptors

1997 • 111 citations

Characterization of a Rat Brain Phospholipase D Isozyme

1998 • 99 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.

1991 • 96 citations

Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2.

1991 • 90 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Activation of phospholipase D induced by platelet-derived growth factor is dependent upon the level of phospholipase C-gamma 1.

1994 • 85 citations

Role of Rho Family Proteins in Phospholipase D Activation by Growth Factors

1997 • 83 citations

Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor.

1994 • 80 citations

Sustained increase in 1,2-diacylglycerol precedes DNA synthesis in epidermal-growth-factor-stimulated fibroblasts. Evidence for stimulated phosphatidylcholine hydrolysis

1990 • 73 citations

Involvement of Phosphatidylcholine-specific Phospholipase C in Platelet-derived Growth Factor-induced Activation of the Mitogen-activated Protein Kinase Pathway in Rat-1 Fibroblasts

1997 • 71 citations

Epidermal Growth Factor Signaling and Mitogenesis inPlcg1Null Mouse Embryonic Fibroblasts

1998 • 69 citations

Basic FGF activates phospholipase D in endothelial cells in the absence of inositol-lipid hydrolysis

1994 • 47 citations

Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH‐3T3 fibroblasts

1993 • 42 citations

Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways

1997 • 23 citations

Phosphatidylcholine hydrolysis: a source of multiple lipid messenger molecules

1993 • 9 citations

Over‐expression of human phospholipase C‐γ2 enhances platelet‐derived growth factor‐induced mobilization of intracellular Ca²⁺ and the release of arachidonic acid and prostaglandins in NIH 3T3 fibroblasts

1992 • 8 citations

Inhibition of PDGF-induced phospholipase C activation by herbirnycin A

1996 • 3 citations