A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

[31] Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands

1988 • 1,048 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells.

1989 • 529 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family

1988 • 414 citations

Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI).

1993 • 363 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Requirement of phosphatidylinositol 4,5-bisphosphate for α-actinin function

1992 • 320 citations

Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides.

1990 • 304 citations

Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum.

1988 • 299 citations

Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.

1990 • 277 citations

gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein

1990 • 225 citations

Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin.

1992 • 206 citations

Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

1993 • 200 citations

Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins.

1991 • 195 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

A GDP Dissociation Inhibitor That Serves as a GTPase Inhibitor for the Ras-Like Protein CDC42Hs

1992 • 164 citations

A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation.

1992 • 144 citations

Signal transduction through small GTPases—A tale of two GAPs

1992 • 137 citations

Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.

1993 • 123 citations

Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain.

1988 • 108 citations

Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis.

1993 • 104 citations

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

1993 • 95 citations

Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes.

1992 • 94 citations

Multiple forms of phospholipase C isozymes and their activation mechanisms.

1992 • 88 citations

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1992 • 76 citations

bcr genes and transcripts.

1988 • 74 citations

Identification of the human platelet GTPase activating protein for the CDC42Hs protein.

1991 • 71 citations

Functional Modification of a 21-Kilodalton G Protein when ADP-Ribosylated by Exoenzyme C3 of Clostridium botulinum

1988 • 66 citations

Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region.

1992 • 62 citations

Isolation and characterization of a γ-type phosphoinositide-specific phospholipase C (PLC-γ2)

1990 • 52 citations

Purification of GTPase-activating protein specific for the rho gene products.

1991 • 51 citations

Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP

1991 • 50 citations

Involvement of rho p21 and Its Inhibitory GDP/GTP Exchange Protein (rho GDI) in Cell Motility

1993 • 46 citations

A Drosophila rotund transcript expressed during spermatogenesis and imaginal disc morphogenesis encodes a protein which is similar to human Rac GTPase-activating (racGAP) proteins.

1992 • 43 citations

Characterization of a promiscuous GTPase-activating protein that has a Bcr-related domain from Caenorhabditis elegans.

1994 • 24 citations

α2-Chimerin, an SH2-Containing GTPase-Activating Protein for the ras-Related Protein p21^rac Derived by Alternate Splicing of the Human n-Chimerin Gene, Is Selectively Expressed in Brain Regions and Testes

1993 • 17 citations