Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold

1995 • 680 citations

Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits

1992 • 630 citations

Modulation of Calmodulin Plasticity in Molecular Recognition on the Basis of X-Ray Structures

1993 • 615 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

1995 • 597 citations

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain.

1995 • 569 citations

Crystal structure of a mammalian phosphoinositide-specific phospholipase Cδ

1996 • 526 citations

Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C

1992 • 506 citations

A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.

1993 • 486 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits

1993 • 444 citations

Mammalian Homologues of Caenorhabditis elegans unc-13 Gene Define Novel Family of C2-domain Proteins

1995 • 404 citations

A gene encoding a phosphatidylinositol-specific phospholipase C is induced by dehydration and salt stress in Arabidopsis thaliana.

1995 • 372 citations

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

1992 • 367 citations

Bipartite Ca ²⁺ -Binding Motif in C ₂ Domains of Synaptotagmin and Protein Kinase C

1996 • 307 citations

Activation of phospholipase C isozymes by G protein beta gamma subunits.

1993 • 306 citations

Lipid Signaling Enzymes and Surface Dilution Kinetics

1995 • 299 citations

Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha.

1993 • 293 citations

Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

1995 • 293 citations

The pleckstrin homology domain of phospholipase C-.delta.1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes

1995 • 286 citations

Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.

1994 • 244 citations

Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide

1994 • 239 citations

A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities.

1995 • 212 citations

Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain.

1994 • 209 citations

Lipid modifications of G proteins

1994 • 206 citations

INTERFACIAL ENZYMOLOGY OF GLYCEROLIPID HYDROLASES: Lessons from Secreted Phospholipases A₂

1995 • 204 citations

Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae.

1993 • 195 citations

Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

1993 • 186 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

Evidence That Phospholipase δ1 Is the Effector in the Gh (Transglutaminase II)-mediated Signaling

1996 • 180 citations

Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins.

1993 • 179 citations

Gβγ interactions with PH domains and Ras-MAPK signaling pathways

1995 • 177 citations

Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol.

1995 • 162 citations

The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth.

1993 • 161 citations

Proteolytic fragments of phosphoinositide-specific phospholipase C-delta 1. Catalytic and membrane binding properties

1993 • 160 citations

Extending the C2 domain family: C2s in PKCs δ, ϵ,η,θ, phospholipases, GAPs, and perforin

1996 • 158 citations

Removal of the carboxyl-terminal region of phospholipase C-beta 1 by calpain abolishes activation by G alpha q.

1993 • 158 citations

Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor

1990 • 153 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1.

1994 • 141 citations

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995 • 137 citations

Activation of phospholipase C-beta 2 mutants by G protein alpha q and beta gamma subunits.

1993 • 134 citations

Signal-activated phospholipases

1994 • 134 citations

A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus

1996 • 124 citations

Phospholipase C δ1 requires a pleckstrin homology domain for interaction with the plasma membrane

1995 • 122 citations

Effect of Monolayer Surface Pressure on the Activities of Phosphoinositide-Specific Phospholipase C-.beta.1, -.gamma.1, and -.delta.1

1994 • 119 citations

Solution structure of the SH3 domain of phospholipase C-?

1993 • 117 citations

Phosphatidylinositol-specific phospholipase C of Bacillus cereus: cloning, sequencing, and relationship to other phospholipases

1989 • 117 citations

Regulation of phospholipase C-beta 4 by ribonucleotides and the alpha subunit of Gq.

1994 • 109 citations

D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes.

1994 • 107 citations

Pleckstrin homology domains: a fact file

1995 • 101 citations

Characterization of a plasma membrane‐associated phosphoinositide‐specific phospholipase C from soybean

1995 • 99 citations

A Mutation in PLC1, a Candidate Phosphoinositide-Specific Phospholipase C Gene from Saccharomyces cerevisiae, Causes Aberrant Mitotic Chromosome Segregation

1993 • 99 citations

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity.

1994 • 97 citations

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

1996 • 96 citations

Platelet-derived growth factor increases the in vivo activity of phospholipase C-gamma 1 and phospholipase C-gamma 2.

1991 • 90 citations

Multiple forms of phospholipase C isozymes and their activation mechanisms.

1992 • 88 citations

Molecular cloning and expression of a phosphoinositide-specific phospholipase C of Dictyostelium discoideum.

1992 • 80 citations

Cloning and Identification of Amino Acid Residues of Human Phospholipase Cδ1 Essential for Catalysis

1995 • 74 citations

[47] Phosphatidylinositol-specific phospholipases C from Bacillus cereus and Bacillus thuringiensis

1991 • 73 citations

Toward the mechanism of phosphoinositide-specific phospholipases C

1994 • 69 citations

Synergistic membrane interactions of the two C2 domains of synaptotagmin.

1994 • 67 citations

Scratching the surface with the PH domain

1995 • 62 citations

Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region.

1992 • 62 citations

Distinctive subtypes of bovine phospholipase C that have preferential expression in the retina and high homology to the norpA gene product of Drosophila.

1993 • 61 citations

Mutations within a highly conserved sequence present in the X region of phosphoinositide-specific phospholipase C-δ1

1995 • 60 citations

A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation.

1993 • 56 citations

Kinetic Analysis of Phospholipase C βIsoforms Using Phospholipid-Detergent Mixed Micelles

1995 • 54 citations

Thrombin-mediated phosphoinositide hydrolysis in Chinese hamster ovary cells overexpressing phospholipase C-delta 1.

1994 • 53 citations

EF‐hand motifs in inositol phospholipid‐specific phospholipase C

1990 • 52 citations

Structural Studies on the PH Domains of Dbl, Sos1, IRS-1, and .beta.ARK1 and Their Differential Binding to G.beta..gamma. Subunits

1995 • 50 citations

Stimulation of phospholipase C‐β₂ by recombinant guanine‐nucleotide‐binding protein βγ dimers produced in a baculovirus/insect cell expression system

1994 • 49 citations

An Arabidopsis cDNA Related to Animal Phosphoinositide-Specific Phospholipase C Genes

1995 • 46 citations

Deletion and Site-Directed Mutagenesis of EF-Hand Domain of Phospholipase C-δ1: Effects on Its Activity

1995 • 43 citations

Mutational analysis of phospholipase C‐β₂

1993 • 34 citations

Binding of phospholipase Cδ1 to phospholipid vesicles

1993 • 32 citations

cDNA Sequence and Gene Locus of the Human Retinal Phosphoinositide-Specific Phospholipase-Cβ4 (PLCB4)

1995 • 28 citations

src-homology 2 (SH2) domain ligation as an allosteric regulator: modulation of phosphoinositide-specific phospholipase Cγ1 structure and activity

1995 • 27 citations

Molecular cloning of the plc1⁺ gene of Schizosaccharomyces pombe, which encodes a putative phosphoinositide‐specific phospholipase C

1995 • 25 citations

Mutational analysis of a putative polyphosphoinositide binding site in phospholipase C‐β₂

1995 • 14 citations