Gelsolin Modulates Phospholipase C Activity In Vivo through Phospholipid Binding

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

1979 • 782 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

Phosphoinositides and Calcium as Regulators of Cellular Actin Assembly and Disassembly

1994 • 524 citations

Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain

1986 • 477 citations

Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

1995 • 436 citations

Localization and Turnover of Phosphatidylinositol 4,5-Bisphosphate in Caveolin-enriched Membrane Domains

1996 • 354 citations

Enhanced Motility in NIH 3T3 Fibroblasts That Overexpress Gelsolin

1991 • 321 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

The pleckstrin homology domain: An intriguing multifunctional protein module

1996 • 285 citations

gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein

1990 • 225 citations

Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin.

1992 • 224 citations

Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor

1996 • 220 citations

Phosphoinositide-binding peptides derived from the sequences of gelsolin and villin.

1992 • 206 citations

Gelsolin-Polyphosphoinositide Interaction

1989 • 200 citations

Thymosin beta 10 and thymosin beta 4 are both actin monomer sequestering proteins.

1993 • 168 citations

Reversible binding of actin to gelsolin and profilin in human platelet extracts.

1987 • 162 citations

A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility.

1996 • 155 citations

Association of gelsolin with actin filaments and cell membranes of macrophages and platelets.

1989 • 151 citations

Identification of a polyphosphoinositide-modulated domain in gelsolin which binds to the sides of actin filaments.

1988 • 148 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein.

1996 • 144 citations

Lipid Products of Phosphoinositide 3-Kinase Bind Human Profilin with High Affinity

1996 • 140 citations

Effects of CapG overexpression on agonist-induced motility and second messenger generation.

1995 • 104 citations

Effects of gelsolin on human platelet cytosolic phosphoinositide-phospholipase C isozymes.

1992 • 94 citations

Gelsolin Binding to Phosphatidylinositol 4,5-Bisphosphate Is Modulated by Calcium and pH

1997 • 84 citations

Profilin and Gelsolin Stimulate Phosphatidylinositol 3-Kinase Activity

1996 • 80 citations

Reversibility of gelsolin/actin interaction in macrophages. Evidence of Ca2+-dependent and Ca2+-independent pathways.

1987 • 71 citations

Phospholipase D Regulation by a Physical Interaction with the Actin-Binding Protein Gelsolin

1996 • 67 citations

gCap39 is a nuclear and cytoplasmic protein

1993 • 55 citations

gCap39 is phosphorylated. Stimulation by okadaic acid and preferential association with nuclei.

1993 • 43 citations

Chimeric and truncated gCap39 elucidate the requirements for actin filament severing and end capping by the gelsolin family of proteins.

1991 • 41 citations

[48] Assays of phosphoinositide-specific phospholipase C and purification of isozymes from bovine brains

1991 • 40 citations

Influence of Dimethyl Sulphoxide on Glycine Transport in Sarcoma-180 Tumour Cells

1968 • 12 citations