Inositol trisphosphate, a novel second messenger in cellular signal transduction

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

1983 • 1,104 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Regulation of insulin release by calcium.

1981 • 866 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets

1983 • 589 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor

1984 • 520 citations

The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions

1981 • 518 citations

Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1981 • 492 citations

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

1984 • 476 citations

Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane

1982 • 475 citations

Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors

1983 • 473 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets.

1983 • 394 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery

1984 • 389 citations

Relationship between inositol polyphosphate production and the increase of cytosolic free Ca2+ induced by vasopressin in isolated hepatocytes.

1984 • 358 citations

Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate

1984 • 337 citations

Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

1982 • 323 citations

myo-inositol polyphosphate may be a messenger for visual excitation in Limulus photoreceptors

1984 • 310 citations

Sources of calcium in egg activation: A review and hypothesis

1983 • 309 citations

Inositol trisphosphates in carbachol-stimulated rat parotid glands

1984 • 296 citations

Thyrotropin-releasing hormone rapidly activates the phosphodiester hydrolysis of polyphosphoinositides in GH3 pituitary cells. Evidence for the role of a polyphosphoinositide-specific phospholipase C in hormone action.

1983 • 292 citations

Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesicles.

1984 • 279 citations

Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

1984 • 278 citations

The phorbol ester TPA increases the affinity of exocytosis for calcium in ‘leaky’ adrenal medullary cells

1983 • 269 citations

The Effects of Intracellular Iontophoretic Injection of Calcium and Sodium Ions on the Light Response of Limulus Ventral Photoreceptors

1972 • 260 citations

Acetylcholine increases the breakdown of triphosphoinositide of rabbit iris muscle prelabelled with [32P] phosphate

1977 • 256 citations

Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: Lipids in search of a function

1982 • 242 citations

Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes

1984 • 238 citations

Guanine nucleotides decrease the free [Ca²⁺] required for secretion of serotonin from permeabilized blood platelets

1984 • 236 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands

1983 • 226 citations

Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli

1984 • 224 citations

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.

1984 • 214 citations

Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.

1984 • 212 citations

Fertilization increases the polyphosphoinositide content of sea urchin eggs

1984 • 209 citations

Thyroliberin stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate by a phosphodiesterase in rat mammotropic pituitary cells. Evidence for an early Ca2+-independent action

1983 • 203 citations

Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins

1984 • 203 citations

Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2

1984 • 203 citations

Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C

1984 • 197 citations

Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms

1984 • 194 citations

Inositol(1,4,5)trisphosphate-promoted Ca2+ release from microsomal fractions of rat liver

1984 • 193 citations

Phorbol myristate acetate stimulates ATP-dependent calcium transport by the plasma membrane of neutrophils.

1984 • 193 citations

Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells

1984 • 190 citations

Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophils

1983 • 188 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

1984 • 184 citations

Membrane transduction mechanisms

1979 • 173 citations

Release of Ca2+ from a non-mitochondrial store site in peritoneal macrophages treated with saponin by inositol 1,4,5-trisphosphate

1984 • 171 citations

Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells

1983 • 170 citations

Inositol trisphosphate mediates thyrotropin-releasing hormone mobilization of nonmitochondrial calcium in rat mammotropic pituitary cells.

1984 • 168 citations

Xenopus oocyte resting potential, muscarinic responses and the role of calcium and guanosine 3',5'‐cyclic monophosphate.

1984 • 153 citations

Acetylcholine Action: Biochemical Aspects

1969 • 152 citations

Secretagogue-induced phosphoinositide metabolism in human leucocytes

1984 • 152 citations

Hepatic alpha 1-adrenergic receptors show agonist-specific regulation by guanine nucleotides. Loss of nucleotide effect after adrenalectomy.

1982 • 149 citations

Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion

1984 • 147 citations

Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

1983 • 145 citations

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21

1984 • 144 citations

alpha-Adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium.

1982 • 143 citations

Localization of sarcoplasmic reticulum proteins in rat skeletal muscle by immunofluorescence.

1979 • 139 citations

Electrical currents through full-grown and maturing Xenopus oocytes.

1979 • 138 citations

The Exocrine Pancreas: The Role of Secretagogues, Cyclic Nucleotides, and Calcium in Enzyme Secretion

1980 • 136 citations

Why is phosphatidylinositol degraded in response to stimulation of certain receptors?

1981 • 135 citations

Acetylglyceryl ether phosphorylcholine. A potent activator of hepatic phosphoinositide metabolism and glycogenolysis.

1983 • 129 citations

Requirement for calcium ions in acetylcholine-stimulated phosphodiesteratic cleavage of phosphatidyl-myo-inositol 4,5-bisphosphate in rabbit iris smooth muscle

1980 • 122 citations

Inositol lipid metabolism in dividing and differentiating cells

1982 • 119 citations

Potentiation by thrombin of the secretion of serotonin from permeabilized platelets equilibrated with Ca2+ buffers. Relationship to protein phosphorylation and diacylglycerol formation

1984 • 110 citations

Thyrotropin-releasing hormone increases cytosolic free Ca2+ in clonal pituitary cells (GH3 cells): direct evidence for the mobilization of cellular calcium.

1984 • 101 citations

12‐O‐Tetradecanoylphorbol 13‐acetate stimulates inositol lipid phosphorylation in intact human platelets

1984 • 99 citations

Identification and metabolism of polyphosphoinositides in isolated islets of Langerhans

1983 • 98 citations

Prostaglandin F_2α stimulates phosphatidylinositol turnover and increases the cellular content of 1,2‐diacylglycerol in confluent resting swiss 3T3 cells

1984 • 97 citations

Islet‐activating protein, pertussis toxin, inhibits Ca²⁺‐induced and guanine nucleotide‐dependent releases of histamine and arachidonic acid from rat mast cells

1984 • 96 citations

Control of 3T3 cell proliferation by calcium

1974 • 94 citations

Metabolism of inositol phosphates in parotid cells: Implications for the pathway of the phosphoinositide effect and for the possible messenger role of inositol trisphosphate

1984 • 93 citations

Subcellular site and mechanism of vasopressin-stimulated hydrolysis of phosphoinositides in rat hepatocytes.

1984 • 89 citations

Receptor regulation of calcium release and calcium permeability in parotid gland cells

1981 • 89 citations

RAPID EFFECTS OF ANGIOTENSIN-I I ON POLYPHOSPHOINOSITIDE METABOLISM IN THE RAT ADRENAL GLOMERULOSA

1984 • 88 citations

Light-regulated biochemical events in invertebrate photoreceptors. 2. Light-regulated phosphorylation of rhodopsin and phosphoinositides in squid photoreceptor membranes

1984 • 86 citations

Regulation of Ca²⁺-Mg²⁺-ATPase Activity in Hepatocyte Plasma Membranes by Vasopressin and Phenylephrine*

1983 • 84 citations

Some mitogens cause rapid increases in free calcium in fibroblasts

1984 • 83 citations

Differential effect of pertussis toxin on the affinity state for agonists of renal alpha 1- and alpha 2- adrenoceptors.

1984 • 79 citations

The enzymology of stimulated inositol lipid turnover

1982 • 77 citations

Secretagogue-induced formation of inositol phosphates in rat exocrine pancreas. Implications for a messenger role for inositol trisphosphate

1984 • 74 citations

Light-regulated biochemical events in invertebrate photoreceptors. 1. Light-activated guanosine triphosphatase, guanine nucleotide binding, and cholera toxin-catalyzed labeling of squid photoreceptor membranes

1984 • 73 citations

Does phosphatidylinositol breakdown control the Ca2+-gating mechanism?

1981 • 67 citations

Triphosphoinositide increases glycoprotein lateral mobility in erythrocyte membranes

1982 • 66 citations

Insertion of diphtheria toxin into and across membranes: role of phosphoinositide asymmetry

1982 • 65 citations

Excitation of Limulus Photoreceptors by Vanadate and by a Hydrolysis-Resistant Analog of Guanosine Triphosphate

1981 • 65 citations

Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM.

1983 • 65 citations

Coupling of polyphosphoinositide breakdown with calcium efflux in formyl‐methionyl‐leucyl‐phenylalanine‐stimulated rabbit neutrophils

1983 • 60 citations

Oncogenes, Inositol Lipids and Cellular Proliferation

1984 • 56 citations

The kinetics of dissociation of the inhibitor of nucleoside transport, nitrobenzylthioinosine, from the high-affinity binding sites of cultured hamster cells

1983 • 54 citations

Serum rapidly mobilizes calcium from an intracellular pool in quiescent fibroblastic cells

1983 • 54 citations

Injection of guanosine and adenosine nucleotides into Limulus ventral photoreceptor cells

1982 • 53 citations

An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor)

1983 • 50 citations

Phytohemagglutinin induces rapid degradation of phosphatidylinositol 4, 5-bisphosphate and transient accumulation of phosphatidic acid and diacylglycerol in a human T lymphoblastoid cell line, CCRF-CEM

1983 • 48 citations

Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells.

1984 • 46 citations

Alpha 1-adrenergic receptor activation mobilizes cellular Ca2+ in a muscle cell line.

1984 • 45 citations

Polyphosphoinositide metabolism in excitable membranes

1983 • 44 citations

Growth effects of lithium chloride in BALB/c 3T3 fibroblasts and madin-darby canine kidney epithelial cells

1981 • 43 citations

Potentiation of phytohemagglutinin stimulation of lymphoid cells by lithium

1979 • 43 citations

Growth effect of lithium on mouse mammary epithelial cells in serum‐free collagen gel culture

1983 • 42 citations

Effects of lithium on angiotensin‐stimulated phosphatidylinositol turnover and aldosterone production in adrenal glomerulosa cells: a possible causal relationship

1984 • 40 citations

Relationship of polyphosphoinositide metabolism to the hormonal activation of the inset salivary gland by 5-hydroxytryptamine

1984 • 39 citations

Muscarinic stimulation of phospholipid turnover in dissociated avian salt gland cells

1983 • 29 citations

Drug Receptors and Their Effectors

1981 • 26 citations

ADP-Induced changes in [32P]phosphate labeling of phosphatidylinositol-4,5-bisphosphate in washed rabbit platelets made refractory by prior ADP stimulation

1983 • 25 citations

Interactions of muscarinic receptors with guanine nucleotides and adenylate cyclase

1981 • 24 citations

Phosphoinositide breakdown in blowfly salivary glands

1984 • 23 citations

A rapid stimulation of phosphatidylinositol metabolism in rabbit leukocytes by pseudomonal leukocidin

1983 • 14 citations