Epidermal growth factor-induced activation and translocation of phospholipase C-gamma 1 to the cytoskeleton in rat hepatocytes.

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins

1991 • 1,931 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

SH2 and SH3 domains: From structure to function

1992 • 977 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation

1990 • 650 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Regulation of Phospholipase C-γ1 by Profilin and Tyrosine Phosphorylation

1991 • 532 citations

The Actin-Binding Protein Profilin Binds to PIP ₂ and Inhibits Its Hydrolysis by Phospholipase C

1990 • 472 citations

"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells?

1988 • 451 citations

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

1992 • 367 citations

SH3 domains direct cellular localization of signaling molecules

1993 • 339 citations

Inositol lipids and cell proliferation

1987 • 315 citations

Hormone-evoked calcium release from intracellular stores is a quantal process

1989 • 312 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

The EGF receptor is an actin-binding protein.

1992 • 248 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

1987 • 230 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

1993 • 181 citations

Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.

1990 • 178 citations

Phosphoinositide metabolism and the control of cell proliferation

1989 • 165 citations

High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

1990 • 150 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Tyrosine Phosphorylation of Phospholipase C-II in Vitro by the Epidermal Growth Factor Receptor

1989 • 145 citations

Quantal calcium release by purified reconstituted inositol 1,4,5-trisphosphate receptors

1992 • 136 citations

Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells.

1990 • 136 citations

Pertussis toxin-sensitive Gi protein involvement in epidermal growth factor-induced activation of phospholipase C-gamma in rat hepatocytes.

1991 • 121 citations

Translocation of pp60c-src to the cytoskeleton during platelet aggregation.

1992 • 120 citations

The epidermal growth factor receptor is associated with actin filaments

1992 • 101 citations

A site of tyrosine phosphorylation in the C terminus of the epidermal growth factor receptor is required to activate phospholipase C.

1992 • 98 citations

Hormone Effects on Cellular Ca²⁺ Fluxes

1989 • 94 citations

Association of the epidermal growth factor receptor kinase with the detergent-insoluble cytoskeleton of A431 cells.

1985 • 89 citations

Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes

1992 • 89 citations

The epidermal growth factor receptor is coupled to a pertussis toxin-sensitive guanine nucleotide regulatory protein in rat hepatocytes

1991 • 87 citations

Ligand‐induced association of epidermal growth factor receptor to the cytoskeleton of A431 cells

1989 • 82 citations

Epidermal growth factor-mediated signaling of G(i)-protein to activation of phospholipases in rat-cultured hepatocytes.

1993 • 78 citations

Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts.

1991 • 69 citations

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

1990 • 69 citations

Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocytes

1992 • 67 citations

Mechanisms of receptor-mediated Ca2+ signaling in rat hepatocytes.

1991 • 64 citations

Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

1991 • 63 citations

Effects of pertussis toxin on growth factor-stimulated inositol phosphate formation and DNA synthesis in Swiss 3T3 cells

1988 • 53 citations

Guanosine 5‵-O-(3-thiotrisphosphate) potentiates both thrombin- and platelet-derived growth factor-induced inositol phosphate release in permeabilized vascular smooth muscle cells

1989 • 53 citations

Effects of the liver tumor promoter ethinyl estradiol on epidermal growth factor-induced DNA synthesis and epidermal growth factor receptor levels in cultured rat hepatocytes.

1989 • 52 citations

Inositol 1,4,5‐trisphosphate activates two types of Ca²⁺‐permeable channels in human carcinoma cells

1990 • 46 citations

Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways

1990 • 32 citations

Non-catalytic activation of phospholipase C-γ 1 in vitro by epidermal growth factor receptor

1993 • 29 citations

Carboxy-terminal truncations of epidermal growth factor (EGF) receptor affect diverse EGF-induced cellular responses.

1991 • 17 citations

Epidermal growth factor activates phospholipase C in rat hepatocytes via a different mechanism from that in A431 or rat1hER cells.

1992 • 17 citations