Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Cleavage of structural proteins during the assemble of the head of bacterio-phage T4

1970 • 5,738 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Diversity of G Proteins in Signal Transduction

1991 • 1,990 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Regulation of Polyphosphoinositide-specific Phospholipase C Activity by Purified G _q

1991 • 886 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.

1990 • 463 citations

Fluoride complexes of aluminium or beryllium act on G-proteins as reversibly bound analogues of the gamma phosphate of GTP.

1987 • 383 citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family

1991 • 373 citations

Polyphosphoinositide phosphodiesterase: regulation by a novel guanine nucleotide binding protein, Gp

1987 • 356 citations

Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

1989 • 355 citations

Cloning and sequence of multiple forms of phospholipase C

1988 • 342 citations

Antibodies to the alpha q subfamily of guanine nucleotide-binding regulatory protein alpha subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones.

1991 • 320 citations

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

1991 • 288 citations

Gz, a guanine nucleotide-binding protein with unique biochemical properties.

1990 • 282 citations

G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells.

1991 • 263 citations

Powerful and versatile enhancer-promoter unit for mammalian expression vectors

1986 • 263 citations

Functionally distinct G proteins selectively couple different receptors to PI hydrolysis in the same cell

1989 • 259 citations

Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.

1988 • 251 citations

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα

1989 • 247 citations

Purification and characterization of two immunologically distinct phosphoinositide-specific phospholipases C from bovine brain.

1987 • 243 citations

Mechanisms of action of calcium‐mobilizing agonists: some variations on a young theme

1988 • 236 citations

Inositol phospholipid-specific phospholipase C: interaction of the γ isoform with tyrosine kinase

1991 • 233 citations

Sequence analysis of cDNA and genomic DNA for a putative pertussis toxin-insensitive guanine nucleotide-binding regulatory protein alpha subunit.

1988 • 207 citations

Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice

1991 • 177 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Purification of unique alpha subunits of GTP-binding regulatory proteins (G proteins) by affinity chromatography with immobilized beta gamma subunits.

1990 • 169 citations

Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.

1990 • 164 citations

Modulation of phosphatidylinositol-specific phospholipase C activity by phospholipid interactions, diglycerides, and calcium ions.

1982 • 158 citations

Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein

1991 • 135 citations

Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.

1987 • 111 citations

Photoaffinity labeling of two rat liver plasma membrane proteins with [32P]gamma-azidoanilido GTP in response to vasopressin. Immunologic identification as alpha subunits of the Gq class of G proteins

1991 • 99 citations

Gαi-αs chimeras define the function of α chain domains in control of G protein activation and βγ subunit complex interactions

1990 • 95 citations

Hormone and growth factor receptor-mediated regulation of phospholipase C activity

1989 • 64 citations

Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin

1991 • 50 citations

Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties

1991 • 45 citations

Expression of a Gαs/Gαi Chimera That Constitutively Activates Cyclic AMP Synthesis

1989 • 45 citations