Cyclic and noncyclic inositol phosphates are formed at different ratios by phospholipase C isozymes

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Cloning and sequence of multiple forms of phospholipase C

1988 • 342 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

Monoclonal antibodies to three phospholipase C isozymes from bovine brain.

1988 • 256 citations

Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

1985 • 233 citations

Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes.

1984 • 225 citations

Specificity of inositol phosphate-stimulated Ca2+ mobilization from Swiss-mouse 3T3 cells

1986 • 190 citations

Inositol phosphates: proliferation, metabolism and function

1988 • 189 citations

The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol

1971 • 177 citations

Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

1985 • 167 citations

The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.

1987 • 164 citations

Purification and characterization of a phosphoinositide-specific phospholipase C from guinea pig uterus. Phosphorylation by protein kinase C in vivo.

1987 • 161 citations

A membrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, <scp>d</scp>-myoinositol 1:2-cyclic phosphate and <scp>d</scp>-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex

1973 • 141 citations

Separation of multiple isomers of inositol phosphates formed in GH3 cells

1987 • 138 citations

Purification of phosphoinositide‐specific phospholipase C from a particulate fraction of bovine brain

1987 • 124 citations

Isolation and characterization of two different forms of inositol phospholipid-specific phospholipase C from rat brain.

1988 • 108 citations

Kinetics of inositol 1,4,5-trisphosphate and inositol cyclic 1:2,4,5-trisphosphate metabolism in intact rat parotid acinar cells. Relationship to calcium signalling.

1988 • 104 citations

Inositol 1,4,5-trisphosphate and inositol 1,2-cyclic 4,5-trisphosphate are minor components of total mass of inositol trisphosphate in thrombin-stimulated platelets. Rapid formation of inositol 1,3,4-trisphosphate.

1987 • 90 citations

Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.

1988 • 90 citations

Catalytic properties of inositol trisphosphate kinase: activation by Ca ²⁺ and calmodulin

1987 • 84 citations

The formation of inositol 1,2-cyclic 4,5-trisphosphate and inositol 1,2-cyclic 4-bisphosphate on stimulation of mouse pancreatic minilobules with carbamylcholine.

1987 • 75 citations

Purification of a phospholipase C from rat liver cytosol that acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate.

1988 • 57 citations

Inositol 1,2-cyclic 4,5-trisphosphate is not a product of μscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands

1987 • 52 citations

Inositol 1:2(cyclic),4,5-trisphosphate is not a major product of inositol phospholipid metabolism in vasopressin-stimulated WRK1 cells

1988 • 47 citations

Inositol 1,2-cyclic 4,5-trisphosphate concentration relative to inositol 1,4,5-trisphosphate in pancreatic minilobules on stimulation with carbamylcholine in the absence of lithium. Possible role as a second messenger in long- but not short-term responses.

1987 • 45 citations

Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors

1989 • 39 citations

Isolation of cyclic inositol-1,2-phosphate from mammalian cells and a probable function of phosphatidylinositol turnover

1974 • 32 citations

Inositol 1,2-cyclic 4,5-trisphosphate is formed in the rat parotid gland on muscarinic stimulation

1987 • 18 citations

Inositol 1,2-cyclic 4,5-trisphosphate is an order of magnitude less potent than inositol 1,4,5-trisphosphate in mobilizing intracellular stores of calcium in mouse pancreatic acinar cells

1989 • 10 citations