Immune privilege in sites of chronic infection: Leishmania and regulatory T cells

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Interleukin-12 and the regulation of innate resistance and adaptive immunity

2003 • 3,689 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

1996 • 1,335 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2005 • 1,189 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome

2000 • 909 citations

Type 1 T regulatory cells

2001 • 829 citations

Regulatory T cells and mechanisms of immune system control

2004 • 809 citations

CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice

2002 • 783 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.

1992 • 709 citations

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

2004 • 690 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

2004 • 654 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function

2002 • 630 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

2002 • 614 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

The lifestyle of naturally occurring CD4⁺CD25⁺Foxp3⁺ regulatory T cells

2006 • 589 citations

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

2004 • 572 citations

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

2001 • 564 citations

Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation

2005 • 561 citations

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

2001 • 549 citations

Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide.

1990 • 531 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

The Role of IL-10 in Promoting Disease Progression in Leishmaniasis

2001 • 511 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

2004 • 474 citations

Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities

2004 • 453 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells

2002 • 440 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

1999 • 417 citations

Cutting Edge: Neutrophil Granulocyte Serves as a Vector forLeishmaniaEntry into Macrophages

2004 • 408 citations

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

2001 • 406 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function

2005 • 397 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion

2004 • 373 citations

Type 1 Interferon (IFNα/β) and Type 2 Nitric Oxide Synthase Regulate the Innate Immune Response to a Protozoan Parasite

1998 • 371 citations

THE ROLE OF pH AND TEMPERATURE IN THE DEVELOPMENT OF LEISHMANIA PARASITES

1994 • 367 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

A Natural Model ofLeishmania majorInfection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity

2000 • 359 citations

T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases

2005 • 349 citations

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.

1991 • 346 citations

Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2

2003 • 345 citations

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

1993 • 345 citations

Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

2007 • 330 citations

God must love galectins; He made so many of them

1999 • 321 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

2006 • 317 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

A Role for CD103 in the Retention of CD4+CD25+ Treg and Control of Leishmania major Infection

2005 • 313 citations

Induction of T helper type 1–like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

2004 • 313 citations

Glycosylation, Immunity, and Autoimmunity

2001 • 303 citations

CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4

2003 • 301 citations

Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasiteLeishmania major

2000 • 298 citations

Role for CD4+ CD25+ Regulatory T Cells in Reactivation of Persistent Leishmaniasis and Control of Concomitant Immunity

2004 • 296 citations

MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll‐like receptor 2 signaling

2003 • 296 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Peripheral Autoantigen Induces Regulatory T Cells that Prevent Autoimmunity

1999 • 284 citations

De novogeneration of antigen-specific CD4⁺CD25⁺regulatory T cells from human CD4⁺CD25^–cells

2005 • 284 citations

Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo

2005 • 283 citations

Oxidative Responses of Human and Murine Macrophages During Phagocytosis ofLeishmania chagasi

2001 • 280 citations

Regulatory T cells and intestinal homeostasis

2005 • 279 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

Multiplication of a Human Parasite ( Leishmania donovani ) in Phagolysosomes of Hamster Macrophages in Vitro

1976 • 274 citations

IL-4-deficient Balb/c mice resist infection with Leishmania major.

1996 • 273 citations

Cc Chemokine Receptor (Ccr)2 Is Required for Langerhans Cell Migration and Localization of T Helper Cell Type 1 (Th1)-Inducing Dendritic Cells

2000 • 273 citations

Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

1998 • 271 citations

Susceptibility of leishmania to oxygen intermediates and killing by normal macrophages

1981 • 267 citations

Fusion of Host Cell Secondary Lysosomes with the Parasitophorous Vacuoles ofLeishmania mexicana-inlected Macrophages

1975 • 266 citations

IL-10 mediates susceptibility toLeishmania donovani infection

2001 • 264 citations

CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages.

1989 • 258 citations

In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting

2002 • 258 citations

Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression

2002 • 253 citations

Role for IL-10 in Suppression Mediated by Peptide-Induced Regulatory T Cells In Vivo

2003 • 252 citations

The Mannose Receptor Mediates Uptake of Pathogenic and Nonpathogenic Mycobacteria and Bypasses Bactericidal Responses in Human Macrophages

1999 • 246 citations

Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells

2001 • 246 citations

Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy

2002 • 246 citations

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses

2000 • 241 citations

Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan ParasiteLeishmania major

2004 • 238 citations

Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH

1990 • 234 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis.

1991 • 231 citations

CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice

2003 • 230 citations

Chemokine Receptor Expression and Function in CD4+ T Lymphocytes with Regulatory Activity

2001 • 218 citations

Glycoconjugates in Leishmania infectivity

1999 • 218 citations

CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction

2004 • 210 citations

Regulatory T cells and autoimmune disease

2005 • 208 citations

Human CD25+ Regulatory T Cells Maintain Immune Tolerance to Nickel in Healthy, Nonallergic Individuals

2003 • 204 citations

Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity

2006 • 202 citations

The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages

1998 • 202 citations

The third component of complement (C3) is responsible for the intracellular survival of Leishmania major

1987 • 198 citations

CD25+CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production

2005 • 198 citations

Genetically Resistant Mice Lacking MyD88-Adapter Protein Display a High Susceptibility to Leishmania major Infection Associated with a Polarized Th2 Response

2003 • 191 citations

Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages.

1996 • 188 citations

Rab5 regulates the kiss and run fusion between phagosomes and endosomes and the acquisition of phagosome leishmanicidal properties in RAW 264.7 macrophages

2000 • 180 citations

A role for the immunological synapse in lineage commitment of CD4 lymphocytes

2004 • 180 citations

Parasite-accessory cell interactions in murine leishmaniasis. II. Leishmania donovani suppresses macrophage expression of class I and class II major histocompatibility complex gene products.

1987 • 178 citations

CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients

1999 • 177 citations

RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon–γ‐primed macrophages

2005 • 177 citations

Defective CCR7 expression on dendritic cells contributes to the development of visceral leishmaniasis

2002 • 177 citations

Immune Elimination ofLeishmania majorin Mice: Implications for Immune Memory, Vaccination, and Reactivation Disease

2001 • 176 citations

Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10

2003 • 176 citations

Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis

2004 • 175 citations

Persistence Without Pathology in Phosphoglycan-Deficient Leishmania major

2003 • 170 citations

The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly

2004 • 168 citations

Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis

1994 • 166 citations

Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes

1988 • 165 citations

Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-γ-triggered JAK2 activation

1999 • 161 citations

Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1

1995 • 160 citations

Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection withLeishmania amazonensis

2003 • 160 citations

Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica.

1980 • 159 citations

Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis.

1993 • 153 citations

Interleukin 1α Promotes Th1 Differentiation and Inhibits Disease Progression in Leishmania major–susceptible BALB/c Mice

2003 • 152 citations

Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells

1995 • 149 citations

The Early IL-4 Response toLeishmania majorand the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells

2002 • 146 citations

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction inLeishmania -infected cells

1998 • 145 citations

Subversion of a young phagosome: the survival strategies of intracellular pathogens. Microreview

2000 • 145 citations

Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani within human monocytes.

1990 • 144 citations

Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

1997 • 144 citations

The Potency and Durability of DNA- and Protein-Based Vaccines Against Leishmania major Evaluated Using Low-Dose, Intradermal Challenge

2001 • 143 citations

Immunologic Determinants of Disease Evolution in Localized Cutaneous Leishmaniasis due toLeishmania major

1998 • 137 citations

Defective stimulus-response coupling in human monocytes infected with Leishmania donovani is associated with altered activation and translocation of protein kinase C.

1992 • 134 citations

Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana

2000 • 134 citations

The development of effector and memory T cells in cutaneous leishmaniasis: the implications for vaccine development

2004 • 134 citations

Nonhealing Infection despite Th1 Polarization Produced by a Strain of Leishmania major in C57BL/6 Mice

2005 • 132 citations

IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection

2000 • 132 citations

Mimicry of Apoptotic Cells by Exposing Phosphatidylserine Participates in the Establishment of Amastigotes ofLeishmania (L) amazonensisin Mammalian Hosts

2006 • 131 citations

Selective Activation and Expansion of High-Affinity CD4+ T Cells in Resistant Mice upon Infection with Leishmania major

2000 • 130 citations

Leishmania donovani Affects Antigen Presentation of Macrophage by Disrupting Lipid Rafts

2005 • 130 citations

Glycoinositolphospholipids ofLeishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages

1995 • 128 citations

Re‐examination of the immunosuppressive mechanisms mediating non‐cure of Leishmania infection in mice

2004 • 127 citations

The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility toLeishmania major

2003 • 126 citations

IL-12p70 Production byLeishmania major-Harboring Human Dendritic Cells Is a CD40/CD40 Ligand-Dependent Process

2000 • 125 citations

Deficient expression of co‐stimulatory molecules on Leishmania‐infected macrophages

1994 • 123 citations

Interleukin 10–Mediated Immunosuppression by a Variant CD4 T Cell Epitope of Plasmodium falciparum

1999 • 122 citations

CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection

2005 • 121 citations

Nonopsonic Phagocytosis of Zymosan andMycobacterium kansasiiby CR3 (CD11b/CD18) Involves Distinct Molecular Determinants and Is or Is Not Coupled with NADPH Oxidase Activation

2000 • 120 citations

Leishmania donovani lipophosphoglycan causes periphagosomal actin accumulation: correlation with impaired translocation of PKCalpha and defective phagosome maturation

2001 • 117 citations

Murine dendritic cells internalizeLeishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferationin vitro

1999 • 115 citations

Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis

2000 • 114 citations

Specific Recognition and Cleavage of Galectin-3 by Leishmania major through Species-specific Polygalactose Epitope

2002 • 114 citations

Early Enhanced Th1 Response afterLeishmania amazonensisInfection of C57BL/6 Interleukin-10-Deficient Mice Does Not Lead to Resolution of Infection

2002 • 109 citations

Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

2001 • 106 citations

Natural killer cells participate in the early defense against Leishmania major infection in mice

1993 • 104 citations

Leishmania amazonensis-Dendritic Cell Interactions In Vitro and the Priming of Parasite-Specific CD4+ T Cells In Vivo

2001 • 98 citations

Dendritic cells and host resistance to infection

2003 • 98 citations

Macrophage‐T cell interaction in experimental visceral leishmaniasis: failure to express costimulatory molecules on Leishmania‐infected macrophages and its implication in the suppression of cell‐mediated immunity

1995 • 95 citations

CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex–independent Differences within Dendritic Cells

2003 • 95 citations

Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis

2001 • 94 citations

Phagocytosis ofLeishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1998 • 94 citations

LeishmaniaPriming of Human Dendritic Cells for CD40 Ligand-Induced Interleukin-12p70 Secretion Is Strain and Species Dependent

2002 • 93 citations

Rapid Expansion and IL-4 Expression by Leishmania-Specific Naive Helper T Cells In Vivo

2002 • 92 citations

Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans

1999 • 92 citations

Organ‐specific and stage‐dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase

2003 • 90 citations

Dendritic cells as host cells for the promastigote and amastigote stages ofLeishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation

2003 • 90 citations

Parasite accessory cell interactions in murine leishmaniasis. I. Evasion and stimulus-dependent suppression of the macrophage interleukin 1 response by Leishmania donovani.

1987 • 89 citations

Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes

2000 • 85 citations

Interleukin-10 in the regulation of T cell-induced colitis

2003 • 84 citations

RESISTANCE AND ABROGATION OF RESISTANCE TO CUTANEOUS LEISHMANIASIS IN RECONSTITUTED BALB/c NUDE MICE

1981 • 83 citations

Conditions Influencing the Efficacy of Vaccination with Live Organisms againstLeishmania majorInfection

2005 • 81 citations

Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis

1991 • 79 citations

Modulation of phagolysosome biogenesis by the lipophosphoglycan of Leishmania

2004 • 79 citations

Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani.

1996 • 79 citations

Expression of a repeating phosphorylated disaccharide lipophosphoglycan epitope on the surface of macrophages infected with Leishmania donovani

1990 • 78 citations

Interleukin-4 Receptor Alpha-Deficient BALB/c Mice Show an Unimpaired T Helper 2 Polarization in Response toLeishmania majorInfection

2000 • 77 citations

Early IL-4 Production Does Not Predict Susceptibility toLeishmania major

1996 • 76 citations

Differential survival of Leishmania donovani amastigotes in human monocytes.

1983 • 76 citations

Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4⁺ T cells

1996 • 76 citations

Immunopathology of post kala-azar dermal leishmaniasis (PKDL): T-cell phenotypes and cytokine profile

1999 • 74 citations

Presentation of the protective parasite antigen LACK by Leishmania-infected macrophages.

1996 • 72 citations

Breaking tolerance to nickel

2005 • 69 citations

Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages

1990 • 69 citations

Leishmania donovani-Induced Expression of Suppressor of Cytokine Signaling 3 in Human Macrophages: a Novel Mechanism for Intracellular Parasite Suppression of Activation

2003 • 69 citations

Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.

1997 • 68 citations

Early Kinetic Window of Target T Cell Susceptibility to CD25+ Regulatory T Cell Activity

2005 • 68 citations

Leishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages

2005 • 68 citations

Enhancement of macrophage IL-1 production by Leishmania major infection in vitro and its inhibition by IFN-gamma.

1989 • 67 citations

Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction.

1993 • 64 citations

The development of post-kala-azar dermal leishmaniasis (PKDL) is associated with acquisition ofLeishmaniareactivity by peripheral blood mononuclear cells (PBMC)

2000 • 60 citations

IgA Fc receptor (FcαR) cross-linking recruits tyrosine kinases, phosphoinositide kinases and serine/threonine kinases to glycolipid rafts

2002 • 60 citations

The lipophosphoglycan of Leishmania and macrophage protein kinase C

1993 • 59 citations

Correlates of Leishmania-Specific Immunity in the Clinical Spectrum of Infection withLeishmania chagasi

1993 • 55 citations

Mice Lacking NK Cells Develop an Efficient Th1 Response and Control CutaneousLeishmania majorInfection

1999 • 55 citations

Myd88-Dependent In Vivo Maturation of Splenic Dendritic Cells Induced byLeishmania donovaniand Other Leishmania Species

2004 • 54 citations

Increased infectivity of stationary-phase promastigotes of Leishmania donovani: correlation with enhanced C3 binding capacity and CR3-mediated attachment to host macrophages.

1987 • 54 citations

Evolution of Lesion Formation, Parasitic Load, Immune Response, and Reservoir Potential in C57BL/6 Mice following High- and Low-Dose Challenge withLeishmania major

2000 • 53 citations

Leishmania aethiopica Derived from Diffuse Leishmaniasis Patients Preferentially Induce mRNA for Interieukin-10 while Those from Localized Leishmaniasis Patients Induce Interferon-

1997 • 53 citations

Characterization of the Local and Systemic Immune Responses in Patients with Cutaneous Leishmaniasis Due toLeishmania major

1999 • 53 citations

Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection byLeishmania major: Inverse Relationship to Interleukin-12 Production

2002 • 51 citations

Leishmania inhibits STAT1-mediated IFN-γ signaling in macrophages: increased tyrosine phosphorylation of dominant negative STAT1β by Leishmania mexicana

2004 • 50 citations

Leishmania majorModulates Chemokine and Chemokine Receptor Expression by Dendritic Cells and Affects Their Migratory Capacity

2005 • 48 citations

Leishmania-Induced Inhibition of Macrophage Antigen Presentation Analyzed at the Single-Cell Level

2003 • 43 citations

Maintenance of IL-12-responsive CD4+ T cells during a Th2 response inLeishmania major-infected mice

2000 • 39 citations

Antigen presentation by Leishmania mexicana‐infected macrophages: activation of helper T cells by a model parasite antigen secreted into the parasitophorous vacuole or expressed on the amastigote surface

1996 • 38 citations

The Importance of CD11b+ Dendritic Cells in CD4+ T Cell Activation In Vivo

2003 • 34 citations

Leishmania majorPromastigotes Inhibit Dendritic Cell Motility In Vitro

2002 • 31 citations

Natural and Induced Regulatory T Cells

2004 • 28 citations

Antigens targeted to the Leishmania phagolysosome are processed for CD4⁺ T cell recognition

1993 • 26 citations

Inflammatory arthritis and dermatitis in thymectomized, CD25+ cell-depleted adult mice

2005 • 19 citations

TheLeishmania majorLACK Antigen with an Immunodominant Epitope at Amino Acids 156 to 173 Is Not Required for Early Th2 Development in BALB/c Mice

2004 • 19 citations

[Differences in the sensitivity of inbred mice of different lines to Leishmania tropica major].

1973 • 13 citations