T regulatory cells in allergy: Novel concepts in the pathogenesis, prevention, and treatment of allergic diseases

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

2001 • 1,212 citations

Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells

2004 • 1,060 citations

Immunity, Inflammation, and Allergy in the Gut

2005 • 1,036 citations

Role of interleukin 10 in specific immunotherapy.

1998 • 980 citations

IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

2003 • 911 citations

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen

2004 • 782 citations

Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet

2002 • 633 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

2001 • 578 citations

IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10

1998 • 565 citations

Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes

2000 • 554 citations

Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity

2004 • 553 citations

Airway Mucosal Inflammation Even in Patients with Newly Diagnosed Asthma

1993 • 543 citations

Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma

2004 • 497 citations

T cell–mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

2000 • 473 citations

Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom☆☆☆★★★

1998 • 458 citations

Immunologic influences on allergy and the TH1/TH2 balance

2004 • 450 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Mechanisms of immunotherapy

2004 • 428 citations

IL-10–producing T cells suppress immune responses in anergic tuberculosis patients

2000 • 402 citations

T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma.

1991 • 395 citations

Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production.

1989 • 394 citations

Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial

2002 • 354 citations

Das Verhalten der kutanen Tuberkulinreaktion während der Masern

1908 • 337 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 312 citations

Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.

1996 • 312 citations

Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization

2001 • 292 citations

Tregs and allergic disease

2004 • 287 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 282 citations

Helminth Infection Protects Mice from Anaphylaxis via IL-10-Producing B Cells

2004 • 277 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

The effect of immunotherapy on bronchial hyperresponsiveness and eosinophil cationic protein in pollen-allergic patients

1988 • 268 citations

B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10.

1994 • 251 citations

IL‐10‐induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy

1999 • 250 citations

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

1980 • 250 citations

Tregs and allergic disease

2004 • 248 citations

Manipulation of Allergen-Induced Airway Remodeling by Treatment with Anti-TGF-β Antibody: Effect on the Smad Signaling Pathway

2005 • 246 citations

Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell–driven B cell responses

2004 • 241 citations

Histamine in the immune regulation of allergic inflammation

2003 • 240 citations

Expression of growth factors and remodelling of the airway wall in bronchial asthma

1998 • 217 citations

Histamine inhibits the production of interleukin-12 through interaction with H2 receptors.

1998 • 214 citations

Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy.

1985 • 203 citations

T cells and eosinophils cooperate in the induction of bronchial epithelial cell apoptosis in asthma

2002 • 200 citations

Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model

2000 • 185 citations

Allergic rhinitis☆A disease remodeling the upper airways?

2004 • 181 citations

A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3‐kinase binding

2000 • 177 citations

Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients.

1995 • 161 citations

Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells.

1996 • 160 citations

Antigen-specific secretory IgA antibodies in the gut are decreased in a mouse model of food allergy

2004 • 144 citations

Impact of Sublingual Immunotherapy on Specific Antibody Levels in Asthmatic Children Allergic to House Dust Mites

2005 • 139 citations

Transforming growth factor-β and its role in asthma

2003 • 137 citations

Advances in upper airway diseases and allergen immunotherapy

2007 • 129 citations

Activation of the TGF- β /Activin-Smad2 Pathway during Allergic Airway Inflammation

2001 • 125 citations

Anergy and suppression regulate CD4+ T cell responses to a self peptide

2000 • 115 citations

Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

1992 • 114 citations

Novel insights into histamine H₂receptor biology

1997 • 112 citations

Anti-CD86 (B7.2) Treatment Abolishes Allergic Airway Hyperresponsiveness in Mice

1999 • 111 citations

Effects of peptide therapy on ex vivo T-cell responses

1998 • 109 citations

Total and allergen‐specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age

2002 • 99 citations

Interleukin-10–Secreting “Regulatory” T Cells Induced by Glucocorticoids and β₂-Agonists

2005 • 98 citations

Regulation of interleukin-10 secretion by histamine in TH2 cells and splenocytes

2001 • 94 citations

A major allergen gene-fusion protein for potential usage in allergen-specific immunotherapy

2005 • 92 citations

Murine CTLA4-IgG Treatment Inhibits Airway Eosinophilia and Hyperresponsiveness and Attenuates IgE Upregulation in a Murine Model of Allergic Asthma

1997 • 92 citations

Histamine enhances TGF‐β1‐mediated suppression of Th2 responses

2003 • 90 citations

Genes of tolerance

2004 • 70 citations

Allergen‐specific conventional immunotherapy decreases immunoglobulin E‐mediated basophil histamine releasability

2003 • 67 citations

Orphan G-protein coupled receptors: novel drug targets for the pharmaceutical industry.

2000 • 50 citations

Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with β2-adrenergic agonists

2004 • 32 citations

Antigen-Specific T Cell Tolerance Down-Regulates Mast Cell Responses in Vivo

2000 • 29 citations

Advances in upper airway diseases and allergen immunotherapy

2005 • 29 citations

Detection of filaria-specific IgG₄antibodies and filarial DNA, for the screening of blood spots forBrugia timori

2005 • 28 citations