Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

Dendritic cells and the control of immunity

1998 • 14,345 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Innate immune recognition: mechanisms and pathways

2000 • 1,451 citations

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

1999 • 1,381 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

The C‐type lectin superfamily in the immune system

1998 • 1,022 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

1999 • 898 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

The mannose receptor is a pattern recognition receptor involved in host defense

1998 • 640 citations

Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-Term Outcome of Leishmania major Infection in the Mouse Ear Dermis

1998 • 409 citations

The role of CpG motifs in innate immunity

2000 • 349 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Macrophage complement and lectin-like receptors bind Leishmania in the absence of serum.

1985 • 306 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

1998 • 271 citations

APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif

1999 • 255 citations

Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis.

1991 • 231 citations

The control of T cell responses by dendritic cell subsets

2000 • 223 citations

Glycoconjugates in Leishmania infectivity

1999 • 218 citations

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania

1998 • 165 citations

Immunology of leishmaniasis

1992 • 162 citations

Comparison of receptors required for entry of Leishmania major amastigotes into macrophages

1993 • 149 citations

Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation.

1998 • 149 citations

Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins.

1990 • 146 citations

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction inLeishmania -infected cells

1998 • 145 citations

Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes

2000 • 144 citations

Phlebotomus papatasiSand Fly Salivary Gland Lysate Down-Regulates a Th1, but Up-Regulates a Th2, Response in Mice Infected withLeishmania major

1998 • 123 citations

Deficient expression of co‐stimulatory molecules on Leishmania‐infected macrophages

1994 • 123 citations

Fcε Receptor I on Dendritic Cells Delivers IgE-Bound Multivalent Antigens into a Cathepsin S-Dependent Pathway of MHC Class II Presentation

1998 • 121 citations

Murine dendritic cells internalizeLeishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferationin vitro

1999 • 115 citations

The role of macrophage receptors in adhesion and uptake of Leishmania mexicana amastigotes

1995 • 100 citations

A Leishmania protein that modulates interleukin (IL)‐12, IL‐10 and tumor necrosis factor‐α production and expression of B7‐1 in human monocyte‐derived antigen‐presenting cells

1997 • 99 citations

Phagocytosis ofLeishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1998 • 94 citations

Surface antigens of Leishmania mexicana amastigotes: characterization of glycoinositol phospholipids and a macrophage-derived glycosphingolipid

1994 • 84 citations

Phlebotomus papatasiSaliva Inhibits Protein Phosphatase Activity and Nitric Oxide Production by Murine Macrophages

1998 • 61 citations

Antigen Presentation by Macrophages Harboring Intravesicular Pathogens

1999 • 50 citations

Lipophosphoglycan blocks attachment of Leishmania major amastigotes to macrophages

1995 • 40 citations

Role of macrophage complement and lectin-like receptors in binding Leishmania parasites to host macrophages

1985 • 36 citations

Course of Leishmania infection in β2-microglobulin-deficient mice

1993 • 29 citations

Molecular basis for interactions between parasites and the complement cascade.

1988 • 3 citations