Selective Activation and Expansion of High-Affinity CD4+ T Cells in Resistant Mice upon Infection with Leishmania major

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

A Kinetic Basis For T Cell Receptor Repertoire Selection during an Immune Response

1999 • 515 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

Detection of Antigen-Specific T Cells with Multivalent Soluble Class II MHC Covalent Peptide Complexes

1998 • 465 citations

Antigen-Specific Development of Primary and Memory T Cells in Vivo

1995 • 444 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Genetic Susceptibility to Leishmania : IL-12 Responsiveness in T _H 1 Cell Development

1996 • 367 citations

Expression Cloning of a Protective Leishmania Antigen

1995 • 351 citations

T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.

1991 • 323 citations

Production of soluble MHC class II proteins with covalently bound single peptides

1994 • 302 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

An inverse relationship between T cell receptor affinity and antigen dose during CD4⁺T cell responsesin vivoandin vitro

1999 • 259 citations

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

1996 • 258 citations

T _H 1 and T _H 2 Cell Antigen Receptors in Experimental Leishmaniasis

1993 • 204 citations

Early parasite containment is decisive for resistance to Leishmania major infection

1995 • 147 citations

Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host

1993 • 146 citations

Serial Backcross Mapping of Multiple Loci Associated with Resistance to Leishmania major in Mice

1997 • 144 citations

Genetic Regulation of Commitment to Interleukin 4 Production by a CD4+ T Cell–intrinsic Mechanism

1998 • 104 citations

Changes in the precursor frequencies of IL-4 and IFN-gamma secreting CD4+ cells correlate with resolution of lesions in murine cutaneous leishmaniasis.

1992 • 104 citations

Resistance to Leishmania major is Linked to the H2 Region on Chromosome 17 and to Chromosome 9

1997 • 97 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules.

1996 • 88 citations

Effective and Long-Lasting Immunity against the ParasiteLeishmania majorin CD8-Deficient Mice

1998 • 85 citations

T cell and non-T cell compartments can independently determine resistance to Leishmania major.

1995 • 80 citations

Kinetics of T-cell Receptor Binding by Bivalent HLA-DR·Peptide Complexes That Activate Antigen-specific Human T-cells

2000 • 68 citations

Exacerbation of experimental murine cutaneous leishmaniasis with CD4⁺Leishmania major‐specific T cell lines or clones which secrete interferon‐γ and mediate parasite‐specific delayed‐type hypersensitivity

1991 • 57 citations

Polarized Helper-T-Cell Responses againstLeishmania majorin the Absence of B Cells

1999 • 48 citations

Control of Leishmania major by a monoclonal alpha beta T cell repertoire.

1998 • 44 citations

Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice.

1998 • 36 citations

Control of Leishmania major by a Monoclonal αβ T Cell Repertoire

1998 • 34 citations

Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases

1999 • 31 citations

Vβ gene repertoires in T cells expanded in local self‐healing and lethal systemic murine cutaneous leishmaniasis

1994 • 5 citations