Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

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1983 • 52,849 citations

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1981 • 8,657 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

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1980 • 850 citations

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1991 • 783 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Biology of the Macrophage

1986 • 416 citations

The Host-Invader Interplay

1981 • 405 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

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1992 • 356 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH

1990 • 234 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Human Cutaneous Leishmania in a Mouse Macrophage Line: Propagation and Isolation of Intracellular Parasites

1980 • 218 citations

Low-Molecular-Weight Enzyme Inhibitors of Microbial Origin

1982 • 206 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins.

1987 • 197 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

Intracellular trafficking and the parasitophorous vacuole of Leishmania mexicana-infected macrophages

1992 • 168 citations

A study of the differential respiratory burst activity elicited by promastigotes and amastigotes of Leishmania donovani in murine resident peritoneal macrophages.

1984 • 164 citations

The promastigote surface protease (gp63) of Leishmania is expressed but differentially processed and localized in the amastigote stage

1989 • 159 citations

Lymphoid Cell Surface Interaction Structures Detected Using Cytolysis‐Inhibiting Monoclonal Antibodies

1982 • 155 citations

Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host

1993 • 146 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

The flagellar pocket of trypanosomatids

1993 • 123 citations

Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana

1993 • 121 citations

Leishmania mexicana: Amastigote hydrolases in unusual lysosomes

1986 • 105 citations

Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes.

1993 • 102 citations

The major surface protein of Leishmania promastigotes is anchored in the membrane by a myristic acid-labeled phospholipid.

1986 • 100 citations

Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes

1987 • 98 citations

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1981 • 95 citations

Pellicular Microtubules in the Family Trypanosomatidae*

1970 • 92 citations

Leishmania donovani-infected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation

1994 • 86 citations

Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells.

1995 • 83 citations

Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis

1991 • 79 citations

Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC.

1993 • 79 citations

Invariant chain retains MHC class II molecules in the endocytic pathway.

1993 • 73 citations

Biochemical protozoology

1992 • 71 citations

Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages

1990 • 69 citations

The biosynthesis, processing, and immunolocalization of Leishmania pifanoi amastigote cysteine proteinases

1994 • 64 citations

Distribution of mhc class i and of mhc class ii molecules in macrophages infected with Leishmania amazonensis

1994 • 58 citations

Leishmania mexicana: Comparative fine structure of amastigotes and promastigotes in vitro and in vivo

1986 • 48 citations

Inhibition of Leishmania amastigote growth by antipain and leupeptin

1984 • 48 citations

Pellicle-associated structures in the amastigote stage ofTrypanosoma cruziandLeishmaniaspecies

1974 • 43 citations

A block in degradation of mhc class ii-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment

1992 • 40 citations

Invariant chain — a regulator of antigen presentation

1992 • 38 citations

Cathepsin B-like cysteine proteases of Leishmania mexicana

1993 • 37 citations

Leishmania mexicana: A cytochemical and quantitative study of lysosomal enzymes in infected rat bone marrow-derived macrophages

1987 • 35 citations

Leishmania amazonensis: Involvement of cysteine proteinases in the killing of isolated amastigotes by l-leucine methyl ester

1989 • 32 citations

Leishmania amazonensis: Acidic organelles in amastigotes

1988 • 25 citations

The ultrastructure ofLeishmania tropicain the oriental sore

1970 • 23 citations

Proteinase inhibitors protect Leishmania amazonensis amastigotes from destruction by amino acid esters

1988 • 19 citations

Endocytosis of Leishmania-infected macrophages. Fluorometry of pinocytic rate, lysosome-phagosome fusion and intralysosomal pH.

1980 • 14 citations

Cysteine proteinases of leishmanias

1991 • 13 citations

The O-Chain of Brucella abortus Lipopolysaccharide Induces SDS-Resistant MHC Class II Molecules in Mouse B Cells

1994 • 10 citations

Effects of anti-membrane antibodies on killer T cells.

1982 • 9 citations