Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Macrophage deactivation by interleukin 10.

1991 • 1,253 citations

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

2001 • 549 citations

The Role of IL-10 in Promoting Disease Progression in Leishmaniasis

2001 • 511 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

1999 • 417 citations

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

1993 • 345 citations

Interleukin‐4 and interleukin‐10 synergize to inhibit cell‐mediated immunity in vivo

1993 • 341 citations

IL-10 mediates susceptibility toLeishmania donovani infection

2001 • 264 citations

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

1999 • 257 citations

Incidence of BK Virus and JC Virus Viruria in Human Immunodeficiency Virus-Infected and -Uninfected Subjects

1993 • 240 citations

Clinical and Experimental Advances in Treatment of Visceral Leishmaniasis

2001 • 231 citations

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

1997 • 228 citations

Tissue granuloma structure‐function in experimental visceral leishmaniasis

2001 • 200 citations

Immunopathologic Effects of Tumor Necrosis Factor Alpha in Murine Mycobacterial Infection Are Dose Dependent

2000 • 200 citations

Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis

1994 • 181 citations

Neutralization of IL-12 demonstrates the existence of discrete organ-specific phases in the control ofLeishmania donovani

1998 • 166 citations

Intracellular Antimicrobial Activity in the Absence of Interferon-γ: Effect of Interleukin-12 in Experimental Visceral Leishmaniasis in Interferon-γ Gene-disrupted Mice

1997 • 162 citations

IL-10 AND IL-12 ARE THE MAIN REGULATORY CYTOKINES IN VISCERAL LEISHMANIASIS

2000 • 156 citations

IL-10-Deficient Mice Demonstrate Multiple Organ Failure and Increased Mortality During Escherichia coli Peritonitis Despite an Accelerated Bacterial Clearance

2001 • 154 citations

The dynamics of granuloma formation in experimental visceral leishmaniasis.

1988 • 144 citations

High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

1998 • 143 citations

The importance of TGF-beta in murine visceral leishmaniasis.

1998 • 141 citations

Role and effect of TNF-alpha in experimental visceral leishmaniasis.

1994 • 141 citations

Circulating T Helper 1 (Th1) Cell- and Th2 Cell-Associated Cytokines in Indian Patients with Visceral Leishmaniasis

1997 • 138 citations

Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice

1997 • 138 citations

Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection

1995 • 138 citations

Splenic Cytokine Responses in Indian Kala‐Azar before and after Treatment

1998 • 131 citations

Immunochemotherapy for Intracellular Leishmania donovani Infection: Interferon Plus Pentavalent Antimony

1988 • 131 citations

Cloning of Syrian Hamster (Mesocricetus auratus) Cytokine cDNAs and Analysis of Cytokine mRNA Expression in Experimental Visceral Leishmaniasis

1998 • 127 citations

Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis.

1989 • 125 citations

Regional Differences in the Cellular Immune Response to Experimental Cutaneous or Visceral Infection withLeishmania donovani

1998 • 123 citations

Tissue Cytokine Responses in Canine Visceral Leishmaniasis

2001 • 121 citations

The Importance of TGF-β in Murine Visceral Leishmaniasis

1998 • 117 citations

Treatment of visceral leishmaniasis (kala-azar): A decade of progress and future approaches

2000 • 116 citations

Roles of Endogenous Gamma Interferon and Macrophage Microbicidal Mechanisms in Host Response to Chemotherapy in Experimental Visceral Leishmaniasis

2000 • 116 citations

Associations of peak shifts in age-prevalence for human malarias with bednet coverage

2001 • 116 citations

Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi.

1996 • 115 citations

Response to Interferon‐γ plus Pentavalent Antimony in Indian Visceral Leishmaniasis

1997 • 115 citations

Interleukin‐12 Regulates the Response to Chemotherapy in Experimental Visceral Leishmaniasis

2000 • 115 citations

Role and effect of IL-2 in experimental visceral leishmaniasis.

1993 • 109 citations

Visceral Leishmaniasis in Mice Devoid of Tumor Necrosis Factor and Response to Treatment

2000 • 103 citations

Immunomodulatory Role of Interleukin-10 in Visceral Leishmaniasis: Defective Activation of Protein Kinase C-Mediated Signal Transduction Events

2001 • 97 citations

The Role of Interferon- in the Treatment of Visceral and Diffuse Cutaneous Leishmaniasis

1993 • 97 citations

Effect of granulocyte-macrophage colony-stimulating factor in experimental visceral leishmaniasis.

1995 • 87 citations

Mononuclear Cell Subpopulations and Cytokine Levels in Human Visceral Leishmaniasis before and after Chemotherapy

1993 • 86 citations

Experimental Leishmania major infection in mice: role of IL‐10

1999 • 77 citations

Endogenous Interleukin-10 Is Required for Prevention of a Hyperinflammatory Intracerebral Immune Response inListeria monocytogenesMeningoencephalitis

2001 • 73 citations

Behavior of Visceral Leishmania donovani in an Experimentally Induced T Helper Cell 2 (Th2)-Associated Response Model

1997 • 71 citations

Effect of Treatment with Interferon- Alone in Visceral Leishmaniasis

1995 • 62 citations

IL-12 gene-deficient C57BL / 6 mice are susceptible toLeishmania donovani but have diminished hepatic immunopathology

2000 • 61 citations

Anti–Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in the Presence of Lipopolysaccharide

2000 • 61 citations

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Reverses Neutropenia and Reduces Secondary Infections in Visceral Leishmaniasis

1994 • 58 citations

Interleukin-13 in Iranian patients with visceral leishmaniasis: relationship to other Th2 and Th1 cytokines

2001 • 52 citations

Anin VivoAnalysis of Cytokine Production duringLeishmania donovaniInfection inscidMice

1996 • 52 citations

Mononuclear Cell Recruitment, Granuloma Assembly, and Response to Treatment in Experimental Visceral Leishmaniasis: Intracellular Adhesion Molecule 1-Dependent and -Independent Regulation

2000 • 40 citations

Presence of Circulating Levels of Interferon-<FONT FACE=Symbol>g</font>, Interleukin-10 and Tumor Necrosis Factor-<FONT FACE=Symbol>a</font> in Patients with Visceral Leishmaniasis

1998 • 38 citations

Recombinant interleukin-1 alpha augments granuloma formation and cytokine production but not parasite clearance in mice infected with Leishmania donovani

1992 • 24 citations

Increased Levels of Soluble Interleukin‐4 Receptor in the Sera of Patients with Visceral Leishmaniasis

1999 • 21 citations

Modulating ongoing Th2-cell responses in experimental leishmaniasis

1997 • 19 citations

Atovaquone Alone or with Fluconazole as Oral Therapy for Indian Kala‐Azar

1998 • 8 citations