Leishmania amazonensis-Dendritic Cell Interactions In Vitro and the Priming of Parasite-Specific CD4+ T Cells In Vivo

Dendritic cells and the control of immunity

1998 • 14,345 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ.

1990 • 670 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells

1999 • 633 citations

Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 ⁺ T Cells

1992 • 624 citations

Dendritic cells in the T‐cell areas of lymphoid organs

1997 • 572 citations

Identification of an Infective Stage of Leishmania Promastigotes

1984 • 498 citations

Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans

2000 • 498 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

The Cytokine Profile Expressed by Human Dendritic Cells Is Dependent on Cell Subtype and Mode of Activation

1998 • 436 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

A Natural Model ofLeishmania majorInfection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity

2000 • 359 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis

1993 • 277 citations

Modulating the immune response with dendritic cells and their growth factors

2001 • 277 citations

Measles Virus Infects Human Dendritic Cells and Blocks Their Allostimulatory Properties for CD4+ T Cells

1997 • 274 citations

Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.

1997 • 178 citations

Dendritic cells in Leishmania major‐immune mice harbor persistent parasites and mediate an antigen‐specific T cell immune response

1995 • 172 citations

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction inLeishmania -infected cells

1998 • 145 citations

Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines.

1991 • 139 citations

IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection

2000 • 132 citations

IL-12p70 Production byLeishmania major-Harboring Human Dendritic Cells Is a CD40/CD40 Ligand-Dependent Process

2000 • 125 citations

Leishmania major interferes with antigen presentation by infected macrophages.

1993 • 124 citations

Leishmania pifanoi amastigote antigens protect mice against cutaneous leishmaniasis

1995 • 121 citations

Trypanosoma cruziInfects Human Dendritic Cells and Prevents Their Maturation: Inhibition of Cytokines, HLA-DR, And Costimulatory Molecules

1999 • 114 citations

Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

2001 • 106 citations

Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes.

1993 • 102 citations

Phagocytosis ofLeishmania mexicana amastigotes by macrophages leads to a sustained suppression of IL-12 production

1998 • 94 citations

Presentation of theLeishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites

1999 • 85 citations

Leishmania‐infected macrophages sequester endogenously synthesized parasite antigens from presentation to CD4⁺ T cells

1996 • 76 citations

MURINE CUTANEOUS LEISHMANIASIS: RESISTANCE IN RECONSTITUTED NUDE MICE AND SEVERAL F₁HYBRIDS INFECTED WITH LEISHMANIA TROPICA MAJOR

1983 • 62 citations

Evolution of Lesion Formation, Parasitic Load, Immune Response, and Reservoir Potential in C57BL/6 Mice following High- and Low-Dose Challenge withLeishmania major

2000 • 53 citations

Leishmania amazonensis:The Phagocytosis of Amastigotes by Macrophages

1998 • 48 citations

Class II Major Histocompatibility Complex-Deficient Mice Initially Control an Infection with Leishmania major but Succumb to the Disease

1995 • 41 citations

Leishmania Major Infection in Major Histocompatibility Complex Class II-Deficient Mice: CD8+ T Cells Do not Mediate a Protective Immune Response

1996 • 38 citations

Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses

1999 • 37 citations

Molecular and immune mechanisms in the pathogenesis of cutaneous leishmaniasis

1996 • 36 citations

Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens

1995 • 28 citations