CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

1998 • 1,579 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

2003 • 523 citations

Regulatory T cells under scrutiny

2003 • 427 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Chemotherapy for Leishmaniasis: Biochemical Mechanisms, Clinical Efficacy, and Future Strategies

1988 • 383 citations

A Natural Model ofLeishmania majorInfection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity

2000 • 359 citations

Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease

2004 • 322 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

CD4+CD25+ Regulatory T Cells Cure Murine Colitis: The Role of IL-10, TGF-β, and CTLA4

2003 • 301 citations

Role for CD4+ CD25+ Regulatory T Cells in Reactivation of Persistent Leishmaniasis and Control of Concomitant Immunity

2004 • 296 citations

Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?

2004 • 286 citations

Foxp3 and Natural Regulatory T Cells

2003 • 278 citations

Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis

1993 • 277 citations

CD25⁺CD4⁺regulatory T cells suppress CD4⁺T cell‐mediated pulmonary hyperinflammation driven byPneumocystis cariniiin immunodeficient mice

2002 • 276 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

CD86 and CD80 Differentially Modulate the Suppressive Function of Human Regulatory T Cells

2004 • 275 citations

CD25+CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice

2002 • 245 citations

CD4+CD25+ Regulatory T Cells Suppress Differentiation and Functions of Th1 and Th2 Cells, Leishmania major Infection, and Colitis in Mice

2003 • 230 citations

Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection.

1997 • 178 citations

Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells

2004 • 176 citations

Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice

2003 • 174 citations

Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection withLeishmania amazonensis

2003 • 160 citations

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1999 • 156 citations

Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis

2000 • 155 citations

The Early IL-4 Response toLeishmania majorand the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells

2002 • 146 citations

Regulatory Cells and Infectious Agents: Détentes Cordiale and Contraire

2004 • 143 citations

IL-4-Independent Inhibition of IL-12 Responsiveness During Leishmania amazonensis Infection

2000 • 132 citations

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions

2004 • 129 citations

Re‐examination of the immunosuppressive mechanisms mediating non‐cure of Leishmania infection in mice

2004 • 127 citations

Sand Fly Saliva EnhancesLeishmania amazonensisInfection by Modulating Interleukin-10 Production

2004 • 110 citations

GITR Activation Induces an Opposite Effect on Alloreactive CD4+ and CD8+ T Cells in Graft-Versus-Host Disease

2004 • 103 citations

Suppression of IL-12 Transcription in Macrophages Following Fcγ Receptor Ligation

2001 • 101 citations

Leishmania amazonensis-Dendritic Cell Interactions In Vitro and the Priming of Parasite-Specific CD4+ T Cells In Vivo

2001 • 98 citations

The role of CD4+CD25+ regulatory T cells in Leishmania infection

2003 • 96 citations

Dendritic cells as host cells for the promastigote and amastigote stages ofLeishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation

2003 • 90 citations

Enhanced Replication ofLeishmania amazonensisAmastigotes in Gamma Interferon-Stimulated Murine Macrophages: Implications for the Pathogenesis of Cutaneous Leishmaniasis

2004 • 87 citations

Regulatory T cells: mediating compromises between host and parasite

2002 • 86 citations

Presentation of theLeishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites

1999 • 85 citations

Biological Behavior of Leishmania amazonensis Isolated from Humans with Cutaneous, Mucosal, or Visceral Leishmaniasis in Balb/C Mice

1996 • 83 citations

Analysis of T helper cell responses during infection with Leishmania amazonensis.

2002 • 82 citations

Mechanisms of pathogenesis: differences amongst Leishmania species

2002 • 81 citations

Stimulatory and inhibitory signals originatingfrom the macrophage Fcγ receptors

2001 • 81 citations

Antigen‐Specific In Vitro Suppression of Murine Helicobacter pylori‐Reactive Immunopathological T Cells by CD4⁺CD25⁺ Regulatory T Cells

2004 • 80 citations

EFFECTS OF INTRADERMAL GAMMA-INTERFERON IN CUTANEOUS LEISHMANIASIS

1989 • 76 citations

Recent advances in the biochemistry of psychosis.

1960 • 72 citations

Receptor mediated subversion of macrophage cytokine production by intracellular pathogens

1999 • 66 citations

Experimental Infection of Balb/c Mice with Leishmania panamensis and Leishmania mexicana: Induction of Early IFN‐γ but not IL‐4 is Associated with the Development of Cutaneous Lesions

1997 • 31 citations

Parasite interactions with dendritic cells and macrophages: Implications for cutaneous Leishmaniasis caused by Leishmania amazonensis

2003 • 1 citations

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