Subversion of a young phagosome: the survival strategies of intracellular pathogens. Microreview

MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

1999 • 2,766 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Common themes in microbial pathogenicity revisited

1997 • 1,370 citations

Rab11 regulates recycling through the pericentriolar recycling endosome.

1996 • 1,293 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES WITH PHAGOSOMES

1971 • 973 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Arnino Acid Analysis

1996 • 837 citations

Common themes in microbial pathogenicity revisited.

1997 • 782 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

Conjugative Transfer by the Virulence System of Legionella pneumophila

1998 • 709 citations

The Legionnaires' disease bacterium (Legionella pneumophila) inhibits phagosome-lysosome fusion in human monocytes.

1983 • 704 citations

Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus

1994 • 676 citations

Formation of a novel phagosome by the Legionnaires' disease bacterium (Legionella pneumophila) in human monocytes.

1983 • 644 citations

A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function

1997 • 586 citations

Release of secretory products during transient vesicle fusion

1993 • 582 citations

A Coat Protein on Phagosomes Involved in the Intracellular Survival of Mycobacteria

1999 • 573 citations

Association of Legionella pneumophila with the macrophage endoplasmic reticulum

1995 • 556 citations

The exocytotic event in chromaffin cells revealed by patch amperometry

1997 • 555 citations

A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

1999 • 542 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Professional and non-professional phagocytes: an introduction

1995 • 521 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism

1999 • 414 citations

Brucella abortus Transits through the Autophagic Pathway and Replicates in the Endoplasmic Reticulum of Nonprofessional Phagocytes

1998 • 408 citations

Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis

1996 • 394 citations

Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane.

1996 • 387 citations

Legionella pneumophila inhibits acidification of its phagosome in human monocytes.

1984 • 384 citations

A Salmonella virulence protein that inhibits cellular trafficking

1999 • 371 citations

THE ROLE OF pH AND TEMPERATURE IN THE DEVELOPMENT OF LEISHMANIA PARASITES

1994 • 367 citations

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

1998 • 360 citations

Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.

1994 • 358 citations

Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis.

1996 • 357 citations

A two‐component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence

1998 • 344 citations

Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway

1999 • 328 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

Phagocytosis of the legionnaires' disease bacterium (legionella pneumophila) occurs by a novel mechanism: Engulfment within a Pseudopod coil

1984 • 317 citations

Phagocytosis by zippers and triggers

1995 • 314 citations

The rab7 gtpase resides on a vesicular compartment connected to lysosomes

1995 • 297 citations

Molecular characterization of phagosomes.

1994 • 287 citations

Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan

1997 • 281 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

Inhibition of macrophage phagosome-lysosome fusion by Salmonella typhimurium

1991 • 271 citations

RAB3 AND SYNAPTOTAGMIN: The Yin and Yang of Synaptic Membrane Fusion

1998 • 260 citations

VirulentBrucella abortusPrevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

1998 • 256 citations

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis

1995 • 252 citations

Controlling the maturation of pathogen-containing vacuoles: a matter of life and death

1999 • 241 citations

The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells

1999 • 234 citations

A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis

2000 • 233 citations

Molecular Requirements for Bi-directional Movement of Phagosomes Along Microtubules

1997 • 232 citations

Evidence for pore‐forming ability by Legionella pneumophila

1998 • 227 citations

SAFE HAVEN: The Cell Biology of Nonfusogenic Pathogen Vacuoles

1997 • 227 citations

The Chlamydia trachomatis IncA protein is required for homotypic vesicle fusion

1999 • 225 citations

Alterations in the protein composition of maturing phagosomes.

1992 • 205 citations

The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages

1998 • 202 citations

Lysosomal Enzyme Trafficking between Phagosomes, Endosomes, and Lysosomes in J774 Macrophages

1998 • 201 citations

Twenty years of two‐dimensional electrophoresis: Past, present and future

1996 • 193 citations

An invasion-associated Salmonella protein modulates the actin-bundling activity of plastin

1999 • 193 citations

Identification of Brucella suis Genes Affecting Intracellular Survival in an In Vitro Human Macrophage Infection Model by Signature-Tagged Transposon Mutagenesis

2000 • 184 citations

Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry.

1997 • 179 citations

Endosome fusion in living cells overexpressing GFP-rab5

1999 • 179 citations

Intracellular trafficking and the parasitophorous vacuole of Leishmania mexicana-infected macrophages

1992 • 168 citations

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania

1998 • 165 citations

Impaired recruitment of the small GTPase rab7 correlates with the inhibition of phagosome maturation by Leishmania donovani promastigotes

1999 • 161 citations

Regulation of Membrane Trafficking

1999 • 155 citations

The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?

1996 • 144 citations

Rapid and complete fusion of macrophage lysosomes with phagosomes containing Salmonella typhimurium

1996 • 139 citations

Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010

1998 • 136 citations

Different fates of phagocytosed particles after delivery into macrophage lysosomes.

1996 • 131 citations

Phagocytic processing of the macrophage endoparasite, Mycobacterium avium, in comparison to phagosomes which contain Bacillus subtilis or latex beads.

1995 • 130 citations

Molecular size-fractionation during endocytosis in macrophages.

1995 • 130 citations

Membrane trafficking along the phagocytic pathway

1995 • 130 citations

Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosomes

1997 • 130 citations

In Vitro Fusion of Phagosomes with Different Endocytic Organelles from J774 Macrophages

1998 • 127 citations

Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages

1997 • 124 citations

The fusion pore and mechanisms of biological membrane fusion

1996 • 120 citations

Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment

1994 • 117 citations

Leishmania promastigotes require lipophosphoglycan to actively modulate the fusion properties of phagosomes at an early step of phagocytosis

2000 • 114 citations

Phagosome maturation and fusion with lysosomes in relation to surface property and size of the phagocytic particle.

1997 • 113 citations

The exocytotic fusion pore modeled as a lipidic pore

1992 • 112 citations

Characterization of the Chlamydia trachomatis vacuole and its interaction with the host endocytic pathway in HeLa cells

1997 • 112 citations

Transport of phagosomal components to an endosomal compartment.

1992 • 110 citations

Phagolysosome Formation, Cyclic Adenosine 3':5'-Monophosphate and the Fate of Salmonella typhimurium within Mouse Peritoneal Macrophages

1979 • 106 citations

Phagosomes Are Fully Competent Antigen-Processing Organelles That Mediate the Formation of Peptide:Class II MHC Complexes

1999 • 87 citations

Increased Expression of Rab5a Correlates Directly with Accelerated Maturation of Listeria monocytogenesPhagosomes

1999 • 85 citations

Characterization and subcellular localization of target membrane soluble NSF attachment protein receptors (t-SNAREs) in macrophages. Syntaxins 2, 3, and 4 are present on phagosomal membranes.

1996 • 84 citations

Characterization and intracellular trafficking pattern of vacuoles containing Chlamydia pneumoniae in human epithelial cells

1999 • 76 citations

Live Salmonella Recruits N-Ethylmaleimide–Sensitive Fusion Protein on Phagosomal Membrane and Promotes Fusion with Early Endosome

2000 • 71 citations

Specific inhibition of phagosome-lysosome fusion in murine macrophages mediated bySalmonella typhimuriuminfection

1990 • 71 citations

Mycobacterial phagosome maturation, rab proteins, and intracellular trafficking

1997 • 70 citations

Differential and sequential delivery of fluorescent lysosomal probes into phagosomes in mouse peritoneal macrophages.

1987 • 69 citations

Reconstitution of Phagosome-Lysosome Fusion in StreptolysinO-permeabilized Cells

1997 • 69 citations

Neisseria gonorrhoeae Porin Modulates Phagosome Maturation

1998 • 68 citations

Membrane proteins of the vacuolar system. III. Further studies on the composition and recycling of endocytic vacuole membrane in cultured macrophages

1983 • 65 citations

Analysis and isolation of endocytic vesicles by flow cytometry and sorting: demonstration of three kinetically distinct compartments involved in fluid-phase endocytosis.

1985 • 64 citations

Potent inhibition of viral fusion by the lipophosphoglycan of Leishmania donovani

1995 • 62 citations

Coiling Phagocytosis of Trypanosomatids and Fungal Cells

1998 • 62 citations

Cell biology and the genome projects a concerted strategy for characterizing multiprotein complexes by using mass spectrometry

1997 • 61 citations

Anterograde transport through the Golgi complex: do Golgi tubules hold the key?

1995 • 55 citations

Legionnaires' disease: the pore macrophage and the legion of terror within

1998 • 51 citations

Cytochemical Localization of Plasma Membrane Enzyme Markers During Interiorization of Tachyzoites of Toxoplasma gondii by Macrophages

1989 • 49 citations

Reprogramming the phagocytic pathway—intracellular pathogens and their vacuoles (Review)

1998 • 48 citations

Isolation and characterization of monoclonal antibodies directed against novel components of macrophage phagosomes

1999 • 47 citations

NSF—fusion and beyond

1998 • 46 citations

The Lipophosphoglycan of Leishmania Parasites

1992 • 43 citations

Modulation of Endocytosis in Nuclear Factor IL-6(−/−) Macrophages Is Responsible for a High Susceptibility to Intracellular Bacterial Infection

1999 • 41 citations

Endocytic membrane traffic with respect to phagosomes in macrophages infected with non-pathogenic bacteria: phagosomal membrane acquires the same composition as lysosomal membrane.

1988 • 39 citations

Coiling Phagocytosis Discriminates between Different Spirochetes and Is Enhanced by Phorbol Myristate Acetate and Granulocyte- Macrophage Colony-Stimulating Factor

1998 • 38 citations

Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules

1999 • 36 citations

Cell biologists sort things out: Analysis and purification of intracellular organelles by flow cytometry

1997 • 35 citations

The Role of pH and Temperature in the Development of Leishmania Parasites

1994 • 30 citations

Gaining insight into a complex organelle, the phagosome, using two‐dimensional gel electrophoresis

1995 • 29 citations

Specific inhibition of phagosome-lysosome fusion in murine macrophages mediated by Salmonella typhimurium infection

1990 • 23 citations

Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules

1995 • 20 citations

Survival of intracellular pathogens within macrophages

1999 • 17 citations

Two‐dimensional gel electrophoresis analysis of endovacuolar organelles

1997 • 16 citations

Cellular Microbiology is launched

1999 • 6 citations