Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana

[12] Determination of total protein

1983 • 1,309 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes

1993 • 896 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

Macrophage Microbicidal Mechanisms In Vivo: Reactive Nitrogen versus Oxygen Intermediates in the Killing of Intracellular Visceral Leishmania donovani

1999 • 417 citations

The Interaction of Leishmania Species with Macrophages

1992 • 323 citations

Double targeted gene replacement for creating null mutants.

1991 • 323 citations

Inhibition of Phagolysosomal Biogenesis by the Leishmania Lipophosphoglycan

1997 • 281 citations

CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages.

1989 • 258 citations

Microbial glycolipids: possible virulence factors that scavenge oxygen radicals.

1989 • 255 citations

Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids

1991 • 235 citations

The Leishmania receptor for macrophages is a lipid-containing glycoconjugate.

1985 • 235 citations

Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH

1990 • 234 citations

Development of a stable Leishmania expression vector and application to the study of parasite surface antigen genes.

1990 • 222 citations

Glycoconjugates in Leishmania infectivity

1999 • 218 citations

Metacyclogenesis in Leishmania promastigotes

1989 • 215 citations

The role of phosphoglycans inLeishmania–sand fly interactions

2000 • 198 citations

Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages.

1996 • 188 citations

Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania

1998 • 165 citations

A Specialized Pathway Affecting Virulence Glycoconjugates of Leishmania

1995 • 156 citations

A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host

1998 • 154 citations

Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins.

1990 • 146 citations

Requirement of lipophosphoglycan for intracellular survival of Leishmania donovani within human monocytes.

1990 • 144 citations

Structure of Leishmania mexicana lipophosphoglycan.

1992 • 131 citations

Passive transfer of Leishmania lipopolysaccharide confers parasite survival in macrophages.

1986 • 127 citations

Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania.

1993 • 125 citations

Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana

1993 • 121 citations

The Regulation of Immunity to Leishmania major

1995 • 98 citations

Filamentous proteophosphoglycan secreted by Leishmania promastigotes forms gel-like three-dimensional networks that obstruct the digestive tract of infected sandfly vectors

1999 • 92 citations

Regulation of macrophage IL-12 synthesis byLeishmania phosphoglycans

1999 • 92 citations

Golgi-mediated post-translational processing of secretory acid phosphatase by Leishmania donovani promastigotes

1990 • 91 citations

A ricin agglutinin-resistant clone of Leishmania donovani deficient in lipophosphoglycan

1988 • 86 citations

Transbilayer inhibition of protein kinase C by the lipophosphoglycan from Leishmania donovani.

1996 • 79 citations

Expression of a repeating phosphorylated disaccharide lipophosphoglycan epitope on the surface of macrophages infected with Leishmania donovani

1990 • 78 citations

The structure of Leishmania major amastigote lipophosphoglycan.

1993 • 77 citations

The role of the lipophosphoglycan ofLeishmaniain vector competence

1994 • 70 citations

Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages

1990 • 69 citations

Two more independent selectable markers for stable transfection of Leishmania

1993 • 65 citations

Molecular Cloning and Characterization of a Novel Repeat-containing Leishmania major Gene,ppg1, That Encodes a Membrane-associated Form of Proteophosphoglycan with a Putative Glycosylphosphatidylinositol Anchor

1999 • 65 citations

Monoclonal antibodies directed against Leishmania secreted acid phosphatase and lipophosphoglycan

1993 • 63 citations

Lipophosphoglycan expression and virulence in Ricin-resistant variants of Leishmania major

1990 • 59 citations

The lipophosphoglycan of Leishmania and macrophage protein kinase C

1993 • 59 citations

Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani.

1993 • 57 citations

Leishmania major: Excreted factor, calcium ions, and the survival of amastigotes

1985 • 57 citations

proteophosphoglycan is expressed by amastigotes and has an immunomodulatory effect on macrophage function

1999 • 54 citations

Proteophosphoglycans from Leishmania promastigotes and amastigotes

1999 • 52 citations

Lipophosphoglycan fromLeishmaniasuppresses agonist-induced interleukin 1β gene expression in human monocytes via a unique promoter sequence

1996 • 47 citations

Designing glycoconjugate biosynthesis for an insidious intent: phosphoglycan assembly in Leishmania parasites

1997 • 46 citations

Immunoregulatory pathways in murine leishmaniasis: different regulatory control during Leishmania mexicana mexicana and Leishmania major infections.

1985 • 44 citations

The Lipophosphoglycan of Leishmania Parasites

1992 • 43 citations

LeishmaniaLipophosphoglycan Reduces Monocyte Transendothelial Migration: Modulation of Cell Adhesion Molecules, Intercellular Junctional Proteins, and Chemoattractants

1998 • 35 citations

Lipophosphoglycan masks recognition of the Leishmania donovani promastigote surface by human kala-azar serum.

1991 • 32 citations

Study of Leishmania major-infected macrophages by use of lipophosphoglycan-specific monoclonal antibodies

1990 • 32 citations

Leishmania amastigotes: resistance to complement-mediated lysis is not due to a failure to fix C3.

1985 • 30 citations

Leishmania donovani has distinct mannosylphosphoryltransferases for the initiation and elongation phases of lipophosphoglycan repeating unit biosynthesis

1998 • 22 citations

Ricin-resistant mutants ofLeishmania majorwhich express modified lipophosphoglycan remain infective for mice

1994 • 20 citations

Characterization of a Novel GDP-mannose:Serine-protein Mannose-1-phosphotransferase from Leishmania mexicana

1999 • 17 citations

Structure-function analysis of Leishmania lipophosphoglycan. Distinct domains that mediate binding and inhibition of endothelial cell function.

1996 • 9 citations

A specialized pathway affecting virulence glycoconjugates of Leishmania

1995 • 7 citations

Regulation of macrophage IL-12 synthesis by Leishmania phosphoglycans

1999 • 3 citations