The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility toLeishmania major

Interleukin-10 and the Interleukin-10 Receptor

2001 • 6,422 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

The immunology of susceptibility and resistance to Leishmania major in mice

2002 • 1,173 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.

1990 • 629 citations

The Role of Interleukin (IL)-10 in the Persistence of Leishmania major in the Skin after Healing and the Therapeutic Potential of Anti–IL-10 Receptor Antibody for Sterile Cure

2001 • 549 citations

The Role of IL-10 in Promoting Disease Progression in Leishmaniasis

2001 • 511 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1998 • 442 citations

IL-4 induces a Th2 response in Leishmania major-infected mice.

1992 • 403 citations

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

1993 • 345 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

Resistance to Leishmania major Induced by Tolerance to a Single Antigen

1996 • 258 citations

A Transgenic Model to Analyze the Immunoregulatory Role of IL-10 Secreted by Antigen-Presenting Cells

1999 • 257 citations

Single Cell Analysis Reveals That IL-4 Receptor/Stat6 Signaling Is Not Required for the In Vivo or In Vitro Development of CD4+ Lymphocytes with a Th2 Cytokine Profile

2000 • 252 citations

Interleukin-10 (IL-10) in Experimental Visceral Leishmaniasis and IL-10 Receptor Blockade as Immunotherapy

2002 • 246 citations

Stat6 Regulation of In Vivo IL-4 Responses

2000 • 194 citations

In susceptible mice, Leishmania major induce very rapid interleukin‐4 production by CD4⁺ T cells which are NK1.1⁻

1995 • 168 citations

Increased expression of proinflammatory cytokines in chronic lesions of human cutaneous leishmaniasis

1994 • 166 citations

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite Substrains

1999 • 156 citations

IL-13 Is a Susceptibility Factor forLeishmania majorInfection

2000 • 156 citations

The Early IL-4 Response toLeishmania majorand the Resulting Th2 Cell Maturation Steering Progressive Disease in BALB/c Mice Are Subject to the Control of Regulatory CD4+CD25+ T Cells

2002 • 146 citations

High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

1998 • 143 citations

Splenic Cytokine Responses in Indian Kala‐Azar before and after Treatment

1998 • 131 citations

Conventional, Naive CD4+ T Cells Provide an Initial Source of IL-4 During Th2 Differentiation

2000 • 122 citations

Interleukin-4 Receptor Alpha-Deficient BALB/c Mice Show an Unimpaired T Helper 2 Polarization in Response toLeishmania majorInfection

2000 • 77 citations

Characterization of T cell-mediated responses in nonhealing and healing Leishmania major infections in the absence of endogenous IL-4.

1997 • 54 citations

Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 duringLeishmania major infection

1999 • 42 citations

Cure of Progressive Murine Leishmaniasis: Interleukin 4 Dominance Is Abolished by Transient CD4+ T Cell Depletion and T Helper Cell Type 1–selective Cytokine Therapy

1999 • 27 citations