Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors

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2004 • 7,983 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response

2006 • 3,773 citations

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

2003 • 2,325 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

The p38 signal transduction pathway Activation and function

2000 • 1,560 citations

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

2003 • 1,527 citations

Toll-like Receptor Signaling

2003 • 1,503 citations

Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

1999 • 1,500 citations

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

2001 • 1,385 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

2008 • 1,268 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2

1999 • 1,252 citations

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

2002 • 1,037 citations

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 • 844 citations

Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages

1999 • 829 citations

Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis

1999 • 813 citations

Pyogenic Bacterial Infections in Humans with IRAK-4 Deficiency

2003 • 789 citations

TNF Regulates Chemokine Induction Essential for Cell Recruitment, Granuloma Formation, and Clearance of Mycobacterial Infection

2002 • 753 citations

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

2003 • 742 citations

Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors

2001 • 709 citations

IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

2002 • 676 citations

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

2005 • 589 citations

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

2003 • 548 citations

PI3K-mediated negative feedback regulation of IL-12 production in DCs

2002 • 534 citations

Cutting Edge: Toll-Like Receptor (TLR)2- and TLR4-Mediated Pathogen Recognition in Resistance to Airborne Infection with Mycobacterium tuberculosis

2002 • 454 citations

Toll-Like Receptor 2-Dependent Inhibition of Macrophage Class II MHC Expression and Antigen Processing by 19-kDa Lipoprotein ofMycobacterium tuberculosis

2001 • 450 citations

MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts

2002 • 446 citations

Infection of Human Macrophages and Dendritic Cells withMycobacterium tuberculosisInduces a Differential Cytokine Gene Expression That Modulates T Cell Response

2001 • 427 citations

The Arg753Gln polymorphism of the human Toll-like receptor 2 gene in tuberculosis disease

2004 • 427 citations

Mannosylated Lipoarabinomannans Inhibit IL-12 Production by Human Dendritic Cells: Evidence for a Negative Signal Delivered Through the Mannose Receptor

2001 • 415 citations

The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

2004 • 396 citations

The β-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria

2006 • 394 citations

Toll-Like Receptor 4 Expression Is Required to Control ChronicMycobacterium tuberculosisInfection in Mice

2002 • 355 citations

NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis

2005 • 351 citations

Different Toll-like receptor agonists induce distinct macrophage responses

2001 • 349 citations

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

2003 • 348 citations

Microbial Pathogenesis of Mycobacterium tuberculosis: Dawn of a Discipline

2001 • 338 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 294 citations

Microbial recognition by Toll-like receptors

2003 • 276 citations

Toll-like receptor pathways in the immune responses to mycobacteria

2004 • 269 citations

Cutting Edge: A Toll-Like Receptor 2 Polymorphism That Is Associated with Lepromatous Leprosy Is Unable to Mediate Mycobacterial Signaling

2003 • 261 citations

Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients

2001 • 259 citations

Toll-Like Receptor 2 (TLR2)-Dependent-Positive and TLR2-Independent-Negative Regulation of Proinflammatory Cytokines by Mycobacterial Lipomannans

2004 • 253 citations

Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

2004 • 246 citations

The 19-kDa Mycobacterium tuberculosis Protein Induces Macrophage Apoptosis Through Toll-Like Receptor-2

2003 • 246 citations

Mycobacterium tuberculosisLprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing

2004 • 243 citations

TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN INFLAMMATION

2002 • 232 citations

Acylation State of the Phosphatidylinositol Hexamannosides from Mycobacterium bovis Bacillus Calmette Guérin and Mycobacterium tuberculosis H37Rv and Its Implication in Toll-like Receptor Response

2003 • 222 citations

Mycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory Signals

2005 • 220 citations

Mycobacterium tuberculosis19-kDa Lipoprotein Inhibits IFN-γ-Induced Chromatin Remodeling ofMHC2TAby TLR2 and MAPK Signaling

2006 • 220 citations

TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG

2003 • 211 citations

The CATERPILLER Protein Monarch-1 Is an Antagonist of Toll-like Receptor-, Tumor Necrosis Factor α-, and Mycobacterium tuberculosis-induced Pro-inflammatory Signals

2005 • 211 citations

Mycobacterium tuberculosis LprA Is a Lipoprotein Agonist of TLR2 That Regulates Innate Immunity and APC Function

2006 • 209 citations

Execution of Macrophage Apoptosis by PE_PGRS33 of Mycobacterium tuberculosis Is Mediated by Toll-like Receptor 2-dependent Release of Tumor Necrosis Factor-α

2006 • 199 citations

Mice Lacking Myeloid Differentiation Factor 88 Display Profound Defects in Host Resistance and Immune Responses to Mycobacterium avium Infection Not Exhibited by Toll-Like Receptor 2 (TLR2)- and TLR4-Deficient Animals

2003 • 198 citations

MyD88-Deficient Mice Display a Profound Loss in Resistance toMycobacterium tuberculosisAssociated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

2004 • 193 citations

Lipoarabinomannan from Mycobacterium tuberculosis Promotes Macrophage Survival by Phosphorylating Bad through a Phosphatidylinositol 3-Kinase/Akt Pathway

2001 • 176 citations

The role of Toll-like receptors in immunity against mycobacterial infection

2002 • 161 citations

Myeloid Differentiation Factor 88–Dependent and –Independent Pathways in Toll‐Like Receptor Signaling

2003 • 158 citations

Prolonged Toll-Like Receptor Signaling byMycobacterium tuberculosisand Its 19-Kilodalton Lipoprotein Inhibits Gamma Interferon-Induced Regulation of Selected Genes in Macrophages

2004 • 156 citations

The role of Toll-like receptors in combating mycobacteria

2004 • 152 citations

MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis

2003 • 146 citations

Bacillus Calmette Guérin triggers the IL‐12/IFN‐γ axis by an IRAK‐4‐ and NEMO‐dependent, non‐cognate interaction between monocytes, NK, and T lymphocytes

2004 • 145 citations

The Mycobacterial 38-Kilodalton Glycolipoprotein Antigen Activates the Mitogen-Activated Protein Kinase Pathway and Release of Proinflammatory Cytokines through Toll-Like Receptors 2 and 4 in Human Monocytes

2006 • 144 citations

Differential Regulation of the Mitogen-Activated Protein Kinases by Pathogenic and Nonpathogenic Mycobacteria

2002 • 124 citations

Differential Responses of Bovine Macrophages toMycobacterium aviumsubsp.paratuberculosisandMycobacterium aviumsubsp.avium

2002 • 112 citations

Toll-like receptor 4 plays a protective role in pulmonary tuberculosis in mice

2004 • 112 citations

Induction of p38 Mitogen-activated Protein Kinase Reduces Early Endosome Autoantigen 1 (EEA1) Recruitment to Phagosomal Membranes

2003 • 109 citations

Intracellular network of phosphatidylinositol 3-kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen-activated protein kinases pathways for regulating mycobacteria-induced IL-23 expression in human macrophages

2006 • 105 citations

Mycobacterium tuberculosis Lipoarabinomannan-mediated IRAK-M Induction Negatively Regulates Toll-like Receptor-dependent Interleukin-12 p40 Production in Macrophages

2005 • 103 citations

Role of mitogen-activated protein kinase pathways in the production of tumor necrosis factor-alpha, interleukin-10, and monocyte chemotactic protein-1 by Mycobacterium tuberculosis H37Rv-infected human monocytes.

2003 • 100 citations

NFκB and Sp1 Elements Are Necessary for Maximal Transcription of Toll-like Receptor 2 Induced byMycobacterium avium

2001 • 99 citations

Activation of the Mitogen-Activated Protein Kinase Signaling Pathway Is Instrumental in Determining the Ability ofMycobacterium aviumto Grow in Murine Macrophages

2002 • 88 citations

Increased Mitogen-Activated Protein Kinase Activity and TNF-α Production Associated with Mycobacterium smegmatis- but Not Mycobacterium avium-Infected Macrophages Requires Prolonged Stimulation of the Calmodulin/Calmodulin Kinase and Cyclic AMP/Protein Kinase A Pathways

2004 • 86 citations

Mycobacterium tuberculosisTriggers Apoptosis in Peripheral Neutrophils Involving Toll-Like Receptor 2 and p38 Mitogen Protein Kinase in Tuberculosis Patients

2004 • 85 citations

Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection

2003 • 84 citations

Mycobacterial Infection in MyD88‐Deficient Mice

2003 • 79 citations

Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guérin by Flt3-ligand generated dendritic cells

2006 • 75 citations

Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner

2006 • 70 citations

Macrophage’s Proinflammatory Response to a Mycobacterial Infection Is Dependent on Sphingosine Kinase-Mediated Activation of Phosphatidylinositol Phospholipase C, Protein Kinase C, ERK1/2, and Phosphatidylinositol 3-Kinase

2006 • 65 citations

Toll-like Receptor 2 and Mitogen- and Stress-activated Kinase 1 Are Effectors of Mycobacterium avium-induced Cyclooxygenase-2 Expression in Macrophages

2004 • 63 citations

Protein kinase C zeta plays an essential role for Mycobacterium tuberculosis-induced extracellular signal-regulated kinase 1/2 activation in monocytes/macrophages via Toll-like receptor 2

2006 • 57 citations

Non–Mannose-capped Lipoarabinomannan Induces Lung Inflammation via Toll-like Receptor 2

2004 • 54 citations

Differential Activation of the Transcription Factor Cyclic AMP Response Element Binding Protein (CREB) in Macrophages following Infection with Pathogenic and Nonpathogenic Mycobacteria and Role for CREB in Tumor Necrosis Factor Alpha Production

2004 • 54 citations

Mitogen activated protein kinasep38 pathway is an important component of the anti-inflammatory response in Mycobacterium avium subsp. paratuberculosis-infected bovine monocytes

2006 • 49 citations

Intracellular TLR Signaling: A Structural Perspective on Human Disease

2006 • 43 citations

Determinant role for Toll-like receptor signalling in acute mycobacterial infection in the respiratory tract

2006 • 42 citations

The production of tumour necrosis factor-alpha is decreased in peripheral blood mononuclear cells from multidrug-resistant tuberculosis patients following stimulation with the 30-kDa antigen of Mycobacterium tuberculosis

2003 • 39 citations

Activation and Mitogen-Activated Protein Kinase Regulation of Transcription Factors Ets and NF-κB in Mycobacterium-Infected Macrophages and Role of These Factors in Tumor Necrosis Factor Alpha and Nitric Oxide Synthase 2 Promoter Function

2005 • 37 citations

The effect of mycobacterial virulence and viability on MAP kinase signalling and TNFα production by human monocytes

2003 • 32 citations

The differential interaction of p38 MAP kinase and tumor necrosis factor-α in human alveolar macrophages and monocytes induced by Mycobacterium tuberculois

2004 • 32 citations

Ex Vivo Responses for Interferon‐gamma and Proinflammatory Cytokine Secretion to Low‐Molecular‐Weight Antigen MTB12 of Mycobacterium tuberculosis during Human Tuberculosis

2006 • 16 citations

Mitogenicity of the Recombinant Mycobacterial 27-Kilodalton Lipoprotein Is Not Connected to Its Antiprotective Effect

2004 • 12 citations