Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

Dendritic cells and the control of immunity

1998 • 14,345 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas

1997 • 937 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

1993 • 483 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

The immune response to Leishmania: mechanisms of parasite control and evasion

1998 • 294 citations

Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen‐specific T cells

1993 • 276 citations

Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

1998 • 271 citations

Contact Allergens and Epidermal Proinflammatory Cytokines Modulate Langerhans Cell E-cadherin Expression in Situ

1996 • 176 citations

Dendritic cells in Leishmania major‐immune mice harbor persistent parasites and mediate an antigen‐specific T cell immune response

1995 • 172 citations

Regulation of E-Cadherin-Mediated Adhesion in Langerhans Cell-Like Dendritic Cells by Inflammatory Mediators That Mobilize Langerhans Cells In Vivo

1998 • 164 citations

Parasitism of Epidermal Langerhans Cells in Experimental Cutaneous Leishmaniasis withLeishmania major

1993 • 153 citations

Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction inLeishmania -infected cells

1998 • 145 citations

Leishmania major:Promastigotes Induce Expression of a Subset of Chemokine Genes in Murine Macrophages

1997 • 108 citations

Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.

1997 • 68 citations

Experimental Leishmaniasis in Humans: Review

1991 • 64 citations

Murine epidermal Langerhans cells are potent stimulators of an antigen‐specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis

1992 • 47 citations

E-cadherin-mediated adhesion involving Langerhans cell-like dendritic cells expanded from murine fetal skin.

1997 • 47 citations

Cutaneous host defense in leishmaniasis: interaction of isolated dermal macrophages and epidermal Langerhans cells with the insect-stage promastigote

1988 • 46 citations

Synthesis, stability, and subcellular distribution of major histocompatibility complex class II molecules in Langerhans cells infected with Leishmania major

1997 • 32 citations

Genetic control of Interleukin 12 responsiveness: implications for disease pathogenesis

1997 • 31 citations

The fate and persistence of Leishmania major in mice of different genetic backgrounds: an example of exploitation of the immune system by intracellular parasites

1997 • 26 citations

The Immune Functions of Epidermal Langerhans Cells

1995 • 21 citations