The Regulation of Immunity to Leishmania Major

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

THE LIPOPHOSPHOGLYCAN OF LEISHMANIA PARASITES

1992 • 473 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction.

1993 • 457 citations

Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated macrophages by induction of tumor necrosis factor-alpha.

1990 • 453 citations

B–cell memory is short-lived in the absence of antigen

1988 • 430 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Dendritic cells and macrophages are required for Th1 development of CD4⁺ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-_γ production is IFN-_γ-dependent

1993 • 346 citations

Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major.

1994 • 302 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells

1993 • 265 citations

Tumor necrosis factor plays a protective role in experimental murine cutaneous leishmaniasis.

1989 • 256 citations

Stage-Specific Adhesion of Leishmania Promastigotes to the Sandfly Midgut

1992 • 245 citations

Parasitophorous vacuoles of Leishmania amazonensis-infected macrophages maintain an acidic pH

1990 • 234 citations

Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.

1985 • 225 citations

Murine cutaneous leishmaniasis : Susceptibility correlates with differential expansion of helper T-cell subsets

1987 • 212 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis.

1993 • 153 citations

Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines.

1990 • 149 citations

Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice

1991 • 146 citations

Leishmania infections damage the feeding mechanism of the sandfly vector and implement parasite transmission by bite.

1992 • 131 citations

Involvement of specific Lyt‐2⁺ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

1987 • 108 citations

Cellular and humoral immunity to Leishmania major in genetically susceptible mice after in vivo depletion of L3T4+ T cells.

1987 • 107 citations

Antigen presentation capacity of murine macrophages infected with Leishmania amazonensis amastigotes.

1993 • 102 citations

NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.

1994 • 93 citations

Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis.

1993 • 89 citations

Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes.

1992 • 83 citations

Expression of a repeating phosphorylated disaccharide lipophosphoglycan epitope on the surface of macrophages infected with Leishmania donovani

1990 • 78 citations

Genetically determined susceptibility to Leishmania tropica infection is expressed by haematopoietic donor cells in mouse radiation chimaeras

1980 • 68 citations

Aggravation of experimental cutaneous leishmaniasis in mice by administration of interleukin 3

1988 • 62 citations

MURINE CUTANEOUS LEISHMANIASIS: RESISTANCE IN RECONSTITUTED NUDE MICE AND SEVERAL F₁HYBRIDS INFECTED WITH LEISHMANIA TROPICA MAJOR

1983 • 62 citations

A repetitive peptide of Leishmania can activate T helper type 2 cells and enhance disease progression.

1990 • 61 citations

Antileishmanial defense in macrophages triggered by tumor necrosis factor expressed on CD4+ T lymphocyte plasma membrane.

1991 • 60 citations

Lipophosphoglycan expression and virulence in Ricin-resistant variants of Leishmania major

1990 • 59 citations

Resistance to cutaneous leishmaniasis in nude mice injected with L3T4⁺ T cells but not with Ly‐2⁺ T cells

1988 • 49 citations

Systemic infection of Leishmania tropica (major) in various strains of mice

1981 • 47 citations

Transfected Leishmania expressing biologically active IFN-gamma.

1993 • 44 citations

Leishmania major: Expression and gene structure of the glycoprotein 63 molecule in virulent and avirulent clones and strains

1990 • 39 citations

Tumor necrosis factor alpha (TNF-alpha) and TNF-beta and their receptors in experimental cutaneous leishmaniasis

1994 • 30 citations

Genetic control of the immune response in mice to Leishmania mexicana surface protease.

1991 • 23 citations

Susceptibility of inbred mice to Leishmania tropica infection: genetic control of the development of cutaneous lesions in P/J mice.

1984 • 10 citations