Immune Elimination ofLeishmania majorin Mice: Implications for Immune Memory, Vaccination, and Reactivation Disease

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

T CELL MEMORY

1998 • 863 citations

HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression

1999 • 766 citations

Selecting and maintaining a diverse T-cell repertoire

1999 • 712 citations

Naive T Cells Transiently Acquire a Memory-like Phenotype during Homeostasis-Driven Proliferation

2000 • 644 citations

Tropical and Geographical Medicine.

1984 • 613 citations

A limiting dilution assay for quantifying Leishmania major in tissues of infected mice

1985 • 508 citations

Establishment of Stable, Cell-Mediated Immunity that Makes "Susceptible" Mice Resistant to Leishmania major

1992 • 503 citations

ON IMMUNOLOGICAL MEMORY

1996 • 482 citations

T cell memory is short-lived in the absence of antigen.

1991 • 367 citations

Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major

1997 • 359 citations

Immunology of Leishmaniasis

1993 • 337 citations

Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase.

1996 • 329 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

Homeostatic T Cell Proliferation

2000 • 279 citations

From Naive to Memory T Cells

1996 • 252 citations

Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes.

1987 • 212 citations

IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection

2000 • 207 citations

Antivirally protective cytotoxic T cell memory to lymphocytic choriomeningitis virus is governed by persisting antigen.

1992 • 204 citations

The Host Response to Leishmania Infection

1999 • 201 citations

The role of antigen and IL-12 in sustaining Th1 memory cellsin vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

2000 • 193 citations

Induction of long-lived germinal centers associated with persisting antigen after viral infection.

1996 • 192 citations

Immunological Memory

1993 • 166 citations

Immunologic regulation of experimental cutaneous leishmaniasis. V. Characterization of effector and specific suppressor T cells.

1982 • 163 citations

On the cellular basis of immunological T cell memory

1995 • 159 citations

Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host

1993 • 146 citations

Parasite dose determines the Th1/Th2 nature of the response toLeishmania major independently of infection route and strain of host or parasite

1998 • 112 citations

A strategy to improve the efficacy of vaccination against tuberculosis and leprosy

1992 • 107 citations

Leishmania–HIV Interaction: Immunopathogenic Mechanisms

1999 • 106 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

Concepts in Vaccine Development

1996 • 95 citations

Visceral leishmaniosis in HIV-positive patients

1998 • 87 citations

Factors controlling the turnover of T memory cells

1997 • 78 citations

A valid ELISPOT assay for enumeration of ex vivo, antigen-specific, IFNγ-producing T cells

1999 • 78 citations

Mechanisms of defense against P. falciparum asexual blood stages in humans

1994 • 73 citations

Analysis of the Cellular Parameters of the Immune Responses contributing to Resistance and Susceptibility of Mice to Infection with the Intracellular Parasite, Leishmania major

1989 • 66 citations

Characterization of the immunological memory state generated in mice susceptible to Leishmania major following exposure to low doses of L. major and resulting in resistance to a normally pathogenic challenge

1996 • 65 citations

Cellular Immunity (Part 1 of 2)

1967 • 62 citations

Role of T cell subsets during the recall of immunologic memory to Leishmania major

1992 • 61 citations

The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis

1998 • 60 citations

Immune mechanisms underlying the premunition against Plasmodium falciparum malaria

1994 • 52 citations

Immunoregulation of malarial infection: balancing the vices and virtues

1998 • 50 citations

Systemic infection of Leishmania tropica (major) in various strains of mice

1981 • 47 citations

Experimental Cutaneous Leishmaniasis: Induction and Regulation of T Cells following Infection of Mice with <i>Leishmania major</i>

1998 • 42 citations

Th Cell Development and Regulation in Experimental Cutaneous Leishmaniasis

1996 • 33 citations

Limiting dilution analysis of CD4 T-cell cytokine production in mice administered native versus polymerized ovalbumin: directed induction of T-helper type-1-like activation.

1996 • 15 citations

Towards a strategy of universally efficacious vaccination against pathogens uniquely susceptible to cell-mediated attack

1996 • 10 citations

2.4. Quantitative Considerations in the Design of Vaccination Strategies Against Pathogens Uniquely Susceptible to Cell-Mediated Attack

1996 • 7 citations