Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

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1995 • 2,437 citations

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Mac‐1: a macrophage differentiation antigen identified by monoclonal antibody

1979 • 1,144 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice.

1993 • 612 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo.

1993 • 487 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody.

1986 • 478 citations

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis.

1995 • 427 citations

Cells in the Marginal Zone of the Spleen

1992 • 411 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Production of gamma interferon by natural killer cells from Toxoplasma gondii-infected SCID mice: regulation by interleukin-10, interleukin-12, and tumor necrosis factor alpha

1994 • 374 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

The role of natural killer cells in innate resistance to infection

1993 • 330 citations

Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1991 • 321 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Regulation of Leishmania populations within the host. I. the variable course of Leishmania donovani infections in mice.

1977 • 264 citations

IL-1 beta is required for IL-12 to induce production of IFN-gamma by NK cells. A role for IL-1 beta in the T cell-independent mechanism of resistance against intracellular pathogens.

1995 • 253 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

Triggering of Natural Killer Cells by the Costimulatory Molecule CD80 (B7-1)

1996 • 233 citations

Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis.

1991 • 231 citations

Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.

1986 • 231 citations

Accessory cell-T lymphocyte interactions. Antigen-dependent and -independent clustering.

1986 • 205 citations

Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis

1994 • 181 citations

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions

1995 • 177 citations

Dendritic cells in Leishmania major‐immune mice harbor persistent parasites and mediate an antigen‐specific T cell immune response

1995 • 172 citations

NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection.

1996 • 148 citations

The role of the innate immune response in Th1 cell development following Leishmania major infection

1995 • 123 citations

Biological function and distribution of human interleukin‐12 receptor β chain

1996 • 83 citations

Infection with Leishmania major induces interleukin-12 production in vivo

1994 • 83 citations

The macrophage resistance gene Lsh/Ity/Bcg

1989 • 82 citations

Leishmania donovani infection in scid mice: lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro

1992 • 79 citations

Behavior of Visceral Leishmania donovani in an Experimentally Induced T Helper Cell 2 (Th2)-Associated Response Model

1997 • 71 citations

Cells and Cytokines in Resistance to Toxoplasma gondii

1996 • 67 citations

Anin VivoAnalysis of Cytokine Production duringLeishmania donovaniInfection inscidMice

1996 • 52 citations

The Surface of Dendritic Cells in the Mouse as Studied with Monoclonal Antibodies

1990 • 47 citations

The Proinflammatory Cytokine Interleukin-12 Occurs as a Cell Membrane-Bound Form on Macrophages

1996 • 29 citations

Acquisition of cell-mediated immunity to Leishmania. I. Primary T-cell activation detected by IL-2 receptor expression.

1987 • 28 citations

Experimental Cutaneous Leishmaniasis: Langerhans Cells Internalize Leishmania Major and Induce an Antigen-Specific T-Cell Response

1993 • 22 citations

How Are NK Cell Responses Regulated during Infection?

1996 • 15 citations

Regulation by Interleukin‐10 of Staphylococcus aureus‐ and Lipopolysaccharide‐Indueed Interleukin‐12 Gene Expression in Human Peripheral Blood Mononuclear Cells

1996 • 3 citations