The Mannose Receptor Mediates Uptake of Pathogenic and Nonpathogenic Mycobacteria and Bypasses Bactericidal Responses in Human Macrophages

Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors.

1993 • 603 citations

Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival.

1975 • 528 citations

Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.

1990 • 501 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor

1991 • 444 citations

CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells.

1991 • 390 citations

The Interaction of Bacteria with Mammalian Cells

1992 • 304 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

Sterically Hindered Analogs of Thyroxine

1958 • 268 citations

Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production.

1997 • 265 citations

CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages.

1989 • 258 citations

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

1987 • 253 citations

Apicomplexan plastids as drug targets

1999 • 249 citations

Mycobacterium avium- and Mycobacterium tuberculosis-containing vacuoles are dynamic, fusion-competent vesicles that are accessible to glycosphingolipids from the host cell plasmalemma.

1996 • 178 citations

Involvement of mannose receptor in cytokine interleukin-1beta (IL-1beta), IL-6, and granulocyte-macrophage colony-stimulating factor responses, but not in chemokine macrophage inflammatory protein 1beta (MIP-1beta), MIP-2, and KC responses, caused by attachment of Candida albicans to macrophages

1997 • 172 citations

Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes

1988 • 165 citations

Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages.

1984 • 160 citations

Dexamethasone increases expression of mannose receptors and decreases extracellular lysosomal enzyme accumulation in macrophages.

1985 • 139 citations

Interaction of Mycobacterium avium complex with human macrophages: roles of membrane receptors and serum proteins

1991 • 125 citations

Phagosome-lysosome fusion is a calcium-independent event in macrophages.

1996 • 115 citations

Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?

1998 • 114 citations

Phagosome maturation and fusion with lysosomes in relation to surface property and size of the phagocytic particle.

1997 • 113 citations

The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation

1995 • 111 citations

Inhibition of O2- generation by dexamethasone is mimicked by lipocortin I in alveolar macrophages.

1989 • 108 citations

Association of rap1 and rap2 proteins with the specific granules of human neutrophils. Translocation to the plasma membrane during cell activation.

1992 • 106 citations

Mycobacteria-macrophage interactions. Macrophage phenotype determines the nonopsonic binding of Mycobacterium tuberculosis to murine macrophages.

1993 • 104 citations

Phagocytic chimeric receptors require both transmembrane and cytoplasmic domains from the mannose receptor.

1992 • 92 citations

Complete and Reversible Inhibition of NADPH Oxidase in Human Neutrophils by Phenylarsine Oxide at a Step Distal to Membrane Translocation of the Enzyme Subunits

1995 • 91 citations

Characteristics of the β-glucan receptor of murine macrophages

1988 • 89 citations

Phagocytosis of Unopsonized Zymosan by Human Monocyte-Derived Macrophages: Maturation and Inhibition by Mannan

1985 • 89 citations

Fusion of Azurophil Granules with Phagosomes and Activation of the Tyrosine Kinase Hck Are Specifically Inhibited During Phagocytosis of Mycobacteria by Human Neutrophils

1998 • 87 citations

Annexin 3 is associated with cytoplasmic granules in neutrophils and monocytes and translocates to the plasma membrane in activated cells

1994 • 86 citations

Entry of Mycobacterium tuberculosis into Mononuclear Phagocytes

1996 • 78 citations

Ligand recognition by purified human mannose receptor

1992 • 77 citations

Mannose Receptor

1993 • 75 citations

Mycobacterial infections of animals: pathology and pathogenesis.

1995 • 73 citations

Modulation of macrophage mannosyl-specific receptors by cultivation on immobilized zymosan. Effects on superoxide-anion release and phagocytosis.

1983 • 68 citations

Identification of a Human Gene (HCK) that Encodes a Protein-Tyrosine Kinase and is Expressed in Hemopoietic Cells

1987 • 63 citations

Generation of Macrophage Variants With 5-Azacytidine: Selection for Mannose Receptor Expression

1987 • 62 citations

Coiling Phagocytosis of Trypanosomatids and Fungal Cells

1998 • 62 citations

Novel Protein-Tyrosine Kinase Gene (hck) Preferentially Expressed in Cells of Hematopoietic Origin

1987 • 62 citations

Comparable Growth of Virulent and Avirulent Mycobacterium tuberculosis in Human Macrophages In Vitro

1996 • 55 citations

Chemical synthesis and seroreactivity of O-(3,6-di-O-methyl-β-d-glucopyranosyl)-(1→4)-O-(2,3-di-O-methyl-α-lrhamnopyranosyl)-(1→9)-oxynonanoyl-bovine serum albumin—the leprosy-specific, natural disaccharide-octyl-neoglycoprotein

1986 • 52 citations

On the Composition of Zymosan

1958 • 47 citations

Nonopsonic uptake of Mycobacterium avium complex by human monocytes and alveolar macrophages.

1992 • 47 citations

Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes

1997 • 43 citations

Synthesis and conformational analysis of methyl 2‐O‐(α‐D‐Mannopyranosyl)‐α‐D‐mannopyranoside

1991 • 38 citations

Mannose-receptor ligands stimulate secretion of lysosomal enzymes from rabbit alveolar macrophages.

1987 • 36 citations

Roles of the complement receptor type 1 (CR1) and type 3 (CR3) on phagocytosis and subsequent phagosome-lysosome fusion inSalmonella-infected murine macrophages

1990 • 34 citations

Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents

1992 • 30 citations

Nonreceptor Protein-Tyrosine Kinases in Neutrophil Activation

1996 • 30 citations

Nonadherent cultures of human monocytes kill Mycobacterium smegmatis, but adherent cultures do not

1996 • 28 citations

Exposure of Macrophages to an Enzymatically Inactive Macrophage Mannose Receptor Ligand Augments KiIIing of Candida albicans

1998 • 26 citations

Expression of Azurophil and specific granule proteins during differentiation of NB4 cells in neutrophils

1998 • 22 citations

α₂‐macroglobulin stimulation of protein tyrosine phosphorylation in macrophages via the mannose receptor for Fcγ receptor‐mediated phagocytosis activation

1996 • 18 citations

Acetylcholinesterase-induced respiratory burst in macrophages: evidence for the involvement of the macrophage mannose-fucose receptor

1996 • 16 citations

Does the induction of macrophage lysosomal enzyme secretion by zymosan involve the mannose receptor?

1983 • 13 citations

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