LeishmaniaPriming of Human Dendritic Cells for CD40 Ligand-Induced Interleukin-12p70 Secretion Is Strain and Species Dependent

Immunobiology of Dendritic Cells

2000 • 6,653 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Recombinant interleukin 12 cures mice infected with Leishmania major.

1993 • 776 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells.

1997 • 615 citations

CD40 Triggering of Heterodimeric IL-12 p70 Production by Dendritic Cells In Vivo Requires a Microbial Priming Signal

2000 • 558 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

High-level IL-12 production by human dendritic cells requires two signals

1998 • 424 citations

Visceral Infection Caused by Leishmania tropica in Veterans of Operation Desert Storm

1993 • 377 citations

A Lipophosphoglycan-Independent Method for Isolation of Infective Leishmania Metacyclic Promastigotes by Density Gradient Centrifugation

2001 • 369 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

A Natural Model ofLeishmania majorInfection Reveals a Prolonged “Silent” Phase of Parasite Amplification in the Skin Before the Onset of Lesion Formation and Immunity

2000 • 359 citations

Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovani

1999 • 357 citations

Deficient IL-12(p35) Gene Expression by Dendritic Cells Derived from Neonatal Monocytes

2001 • 352 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Identification of cell surface carbohydrate and antigenic changes between noninfective and infective developmental stages of Leishmania major promastigotes.

1985 • 338 citations

CD40 Ligand Is Required for Protective Cell-Mediated Immunity to Leishmania major

1996 • 332 citations

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

1996 • 319 citations

Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection

1996 • 311 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Human Dendritic Cells Require Exogenous Interleukin-12–Inducing Factors to Direct the Development of Naive T-Helper Cells Toward the Th1 Phenotype

1997 • 302 citations

Interleukin‐12 production by human polymorphonuclear leukocytes

1995 • 285 citations

Uptake of Leishmania major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin–derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity

1998 • 284 citations

Dendritic cells, but not macrophages, produce IL-12 immediately followingLeishmania donovani infection

1998 • 271 citations

Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction.

1996 • 197 citations

Immunobiology of lnterleukin-12

1998 • 191 citations

Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species

2001 • 171 citations

CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge

1998 • 159 citations

Interleukin‐12 Production by Dendritic Cells

1996 • 155 citations

Parasitism of Epidermal Langerhans Cells in Experimental Cutaneous Leishmaniasis withLeishmania major

1993 • 153 citations

A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-γ treatment

2000 • 138 citations

Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis

2000 • 134 citations

Indian kala-azar caused by Leishmania tropica

1995 • 128 citations

Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells

1999 • 126 citations

IL-12p70 Production byLeishmania major-Harboring Human Dendritic Cells Is a CD40/CD40 Ligand-Dependent Process

2000 • 125 citations

CLINICAL PICTURE OF CUTANEOUS LEISHMANIASIS IN ISFAHAN, IRAN

1994 • 119 citations

Murine dendritic cells internalizeLeishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferationin vitro

1999 • 115 citations

Characterization of the A2–A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection

2001 • 115 citations

Silent infection of bone marrow-derived dendritic cells byLeishmania mexicana amastigotes

2001 • 106 citations

Interferon-α and -β inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14+ precursors

2000 • 100 citations

Regulation of protective immunity against Leishmania major in mice

1998 • 100 citations

The biochemical and serological taxonomy of visceralizingLeishmania

1981 • 89 citations

Visceral Leishmaniasis Unresponsive to Pentostam caused by Leishmania Tropica in Kenya

1989 • 75 citations

Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.

1997 • 68 citations

Cutaneous Leishmaniasis—a Case with Persistent Organisms after Treatment in Presence of Normal Immune Response

1979 • 68 citations

Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells

1998 • 62 citations

Underproduction of Interleukin-12 in Susceptible Mice during Progressive Leishmaniasis Is Due to Decreased CD40 Activity

1998 • 55 citations

Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells

1998 • 45 citations

TREATMENT OF RECURRENT CUTANEOUS LEISHMANIASIS

1995 • 43 citations

Vaccination against the Intracellular PathogensLeishmania majorandL. amazonensisby Directing CD40 Ligand to Macrophages

2001 • 21 citations

Dendritic Cells Induce Immunity to Cutaneous Leishmaniasis in Mice

1997 • 15 citations

The Role of IL‐12 in Regulation of T Helper Cell Subsets in Vivo

1996 • 9 citations