The significance of OX40 and OX40L to T‐cell biology and immune disease

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

CTLA-4 Control over Foxp3 ⁺ Regulatory T Cell Function

2008 • 2,656 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

2007 • 1,712 citations

T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

2004 • 1,657 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 • 1,535 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

2005 • 1,029 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

CD28-mediated co-stimulation: a quantitative support for TCR signalling

2003 • 713 citations

Foxp3 in control of the regulatory T cell lineage

2007 • 690 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

2002 • 588 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

Signals required for programming effector and memory development by CD8⁺ T cells

2006 • 574 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Understanding the generation and function of memory T cell subsets

2005 • 459 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

2008 • 434 citations

The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1

2000 • 429 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

2006 • 390 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

2008 • 383 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

Structural basis for self-association and receptor recognition of human TRAF2

1999 • 355 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

1998 • 340 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Ox40-Ligand Has a Critical Costimulatory Role in Dendritic Cell:T Cell Interactions

1999 • 320 citations

OX40-Deficient Mice Are Defective in Th Cell Proliferation but Are Competent in Generating B Cell and CTL Responses after Virus Infection

1999 • 320 citations

Functional Responses and Costimulator Dependence of Memory CD4+ T Cells

2000 • 318 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

2008 • 298 citations

Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross-priming and tumor regression in mice

2008 • 293 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

2000 • 284 citations

The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2

1999 • 277 citations

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

2005 • 276 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

Identification of a human OX-40 ligand, a costimulator of CD4+ T cells with homology to tumor necrosis factor.

1994 • 271 citations

Cross-Talk between Activated Human NK Cells and CD4+ T Cells via OX40-OX40 Ligand Interactions

2004 • 262 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 247 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo

2003 • 235 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Antiviral CD4+ memory T cells are IL-15 dependent

2007 • 229 citations

CD4+CD3− Accessory Cells Costimulate Primed CD4 T Cells through OX40 and CD30 at Sites Where T Cells Collaborate with B Cells

2003 • 226 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

2007 • 215 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

During Viral Infection of the Respiratory Tract, CD27, 4-1BB, and OX40 Collectively Determine Formation of CD8+ Memory T Cells and Their Capacity for Secondary Expansion

2005 • 210 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

2001 • 207 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation

2006 • 199 citations

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

2007 • 197 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1999 • 190 citations

Real-Time Manipulation of T Cell-Dendritic Cell Interactions In Vivo Reveals the Importance of Prolonged Contacts for CD4+ T Cell Activation

2007 • 187 citations

OX40 Costimulation Enhances Interleukin-4 (IL-4) Expression at Priming and Promotes the Differentiation of Naive Human CD4+ T Cells Into High IL-4–Producing Effectors

1998 • 181 citations

Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

1998 • 181 citations

Costimulation of CD8 T Cell Responses by OX40

2004 • 176 citations

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

2008 • 174 citations

Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein

1999 • 172 citations

Robust B Cell Immunity but Impaired T Cell Proliferation in the Absence of CD134 (OX40)

1999 • 167 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

2004 • 159 citations

Selective depletion of myelin–reactive T cells with the anti–OX–40 antibody ameliorates autoimmune encephalomyelitis

1996 • 159 citations

Association of the Adaptor TANK with the IκB Kinase (IKK) Regulator NEMO Connects IKK Complexes with IKKε and TBK1 Kinases

2002 • 152 citations

4-1BB and OX40 Act Independently to Facilitate Robust CD8 and CD4 Recall Responses

2004 • 151 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central–memory cells

2006 • 151 citations

The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF

2001 • 149 citations

Molecular cloning and characterization of a novel glycoprotein, gp34, that is specifically induced by the human T-cell leukemia virus type I transactivator p40tax.

1991 • 141 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

Organization of plasma membrane functional rafts upon T cell activation

2001 • 138 citations

Organization of plasma membrane functional rafts upon T cell activation

2001 • 137 citations

Heterogeneity of CD4+ and CD8+ T cells

2003 • 136 citations

Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma

2003 • 135 citations

The Crystal Structure of the Costimulatory OX40-OX40L Complex

2006 • 131 citations

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

2008 • 129 citations

CD28, Ox-40, LFA-1, and CD4 Modulation of Th1/Th2 Differentiation Is Directly Dependent on the Dose of Antigen

2000 • 126 citations

The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes

2006 • 123 citations

Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands

2007 • 122 citations

Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection

2006 • 122 citations

Constitutive OX40/OX40 Ligand Interaction Induces Autoimmune-Like Diseases

2002 • 120 citations

Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand

2004 • 118 citations

Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment

2006 • 118 citations

OX40 Ligation Enhances Primary and Memory Cytotoxic T Lymphocyte Responses in an Immunotherapy for Hepatic Colon Metastases

2002 • 115 citations

Activation of NF-κB1 by OX40 Contributes to Antigen-Driven T Cell Expansion and Survival

2008 • 111 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice

2007 • 110 citations

Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients

2003 • 109 citations

Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) Pathway Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice

2006 • 108 citations

Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis

2001 • 108 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen

2006 • 105 citations

Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses

2006 • 103 citations

Critical Role of OX40 in CD28 and CD154-Independent Rejection

2004 • 102 citations

OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity

2006 • 100 citations

Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo

2002 • 98 citations

Anti‐OX40 stimulation in vivo enhances CD8⁺ memory T cell survival and significantly increases recall responses

2006 • 95 citations

Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti‐OX40 and anti‐4‐1BB monoclonal antibodies induces T cell–mediated protective immunity in Her‐2/neu transgenic mice

2005 • 93 citations

The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo

2003 • 91 citations

Adenovirus Vector-Mediatedin VivoGene Transfer of OX40 Ligand to Tumor Cells Enhances Antitumor Immunity of Tumor-Bearing Hosts

2004 • 88 citations

OX40 Costimulation Promotes Persistence of Cytomegalovirus-Specific CD8 T Cells: A CD4-Dependent Mechanism

2007 • 88 citations

Defects in the Acquisition of CD8 T Cell Effector Function after Priming with Tumor or Soluble Antigen Can Be Overcome by the Addition of an OX40 Agonist

2007 • 87 citations

IL-18 Bridges Innate and Adaptive Immunity through IFN-γ and the CD134 Pathway

2006 • 85 citations

OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen

2005 • 84 citations

Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: A possible role in asthma?

2004 • 83 citations

CpG ODN enhance antigen-specific NKT cell activation via plasmacytoid dendritic cells

2005 • 78 citations

Augmentation Versus Inhibition: Effects of Conjunctional OX-40 Receptor Monoclonal Antibody and IL-2 Treatment on Adoptive Immunotherapy of Advanced Tumor

2001 • 78 citations

OX40-Mediated Memory T Cell Generation Is TNF Receptor-Associated Factor 2 Dependent

2003 • 76 citations

Functional expression of CD134 by neutrophils

2004 • 76 citations

OX40 Costimulatory Signals Potentiate the Memory Commitment of Effector CD8+ T Cells

2008 • 74 citations

The CD8⁺ T cell repertoire against Her‐2/neu antigens in neu transgenic mice is of low avidity with antitumor activity

2004 • 73 citations

OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells

2008 • 73 citations

A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T‐cell leukemia virus type‐I (HTLV‐I)

1985 • 72 citations

Antagonism of Airway Tolerance by Endotoxin/Lipopolysaccharide through Promoting OX40L and Suppressing Antigen-Specific Foxp3+ T Regulatory Cells

2008 • 72 citations

Memory T cells have gene expression patterns intermediate between naïve and effector

2005 • 69 citations

IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival

2008 • 69 citations

OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response

2003 • 67 citations

4‐1BB and OX40 stimulation enhance CD8 and CD4 T‐cell responses to a DNA prime, poxvirus boost vaccine

2004 • 65 citations

CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

2003 • 64 citations

Differential Requirements for OX40 Signals on Generation of Effector and Central Memory CD4+ T Cells

2007 • 64 citations

Signaling control of memory T cell generation and function

2004 • 64 citations

Cross-Linking of 4-1BB Activates TCR-Signaling Pathways in CD8+ T Lymphocytes

2005 • 64 citations

Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation

2004 • 62 citations

Regulation of CD4 T cell memory by OX40 (CD134)

2005 • 59 citations

Anti-tumour therapeutic efficacy of OX40L in murine tumour model

2004 • 58 citations

Aging affect the anti-tumor potential of dendritic cell vaccination, but it can be overcome by co-stimulation with anti-OX40 or anti-4-1BB☆

2005 • 57 citations

Fc-mOX40L Fusion Protein Produces Complete Remission and Enhanced Survival in 2 Murine Tumor Models

2008 • 55 citations

Therapeutic effect of anti-OX40L and anti-TNF-α MAbs in a murine model of chronic colitis

2003 • 55 citations

Cooperation between CD4 and CD8 T cells for anti‐tumor activity is enhanced by OX40 signals

2007 • 53 citations

Activation of NF‐kB1 by OX40 contributes to antigen‐driven T cell expansion and survival

2008 • 50 citations

Antiapoptotic function of NF-κB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL

2003 • 50 citations

Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

2002 • 48 citations

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice

2003 • 48 citations

NF-κB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo

2005 • 48 citations

CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

2006 • 44 citations

Functional characterization of OX40 expressed on human CD8+ T cells

2006 • 44 citations

CD134-Allodepletion Allows Selective Elimination of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific Effectors

2008 • 44 citations

Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions

2004 • 43 citations

Expression of gp34 (OX40 Ligand) and OX40 on Human T Cell Clones

2001 • 41 citations

OX40 (CD134) Blockade Inhibits the Co-stimulatory Cascade and Promotes Heart Allograft Survival

2004 • 40 citations

Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4

2006 • 40 citations

OX40 Controls Islet Allograft Tolerance in CD154 Deficient Mice by Regulating FOXP3+ Tregs

2008 • 39 citations

Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand

2003 • 37 citations

Differences in Signaling Molecule Organization between Naive and Memory CD4+ T Lymphocytes

2004 • 36 citations

OX40-Mediated Differentiation to Effector Function Requires IL-2 Receptor Signaling but Not CD28, CD40, IL-12Rβ2, or T-bet

2007 • 35 citations

Both Amino- and Carboxyl-Terminal Domains of TRAF3 Negatively Regulate NF-κB Activation Induced by OX40 Signaling

2000 • 35 citations

CD134 as target for specific drug delivery to auto-aggressive CD4+ T cells in adjuvant arthritis.

2005 • 32 citations

Gene Array and Protein Expression Profiles Suggest Post-transcriptional Regulation during CD8+ T Cell Differentiation

2003 • 31 citations

Costimulation through OX40 is crucial for induction of an alloreactive human T‐cell response

2003 • 26 citations

In vitro and in vivo activities of OX40 (CD134)-IgG fusion protein isoforms with different levels of immune-effector functions

2002 • 24 citations

HVEM Signaling in Monocytes Is Mediated by Intracellular Calcium Mobilization

2007 • 17 citations

Blockade of the OX40 ligand prolongs corneal allograft survival

2007 • 15 citations

Introduction of OX40 ligand into lymphoma cells elicits anti-lymphoma immunity in vivo

2005 • 12 citations