The kinases aurora B and mTOR regulate the G1–S cell cycle progression of T lymphocytes

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Control of apoptosis and mitotic spindle checkpoint by survivin

1998 • 1,881 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

The B7–CD28 superfamily

2002 • 1,646 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.

1998 • 1,243 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Cyclins and cancer

1991 • 701 citations

Pleiotropic cell-division defects and apoptosis induced by interference with survivin function

1999 • 613 citations

Regulation of apoptosis at cell division by p34 ^cdc2 phosphorylation of survivin

2000 • 606 citations

Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle

2000 • 588 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS

1975 • 551 citations

Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase

2005 • 535 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

The expanding TOR signaling network

2005 • 499 citations

Cyclin A in cell cycle control and cancer

2002 • 491 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Signaling by Target of Rapamycin Proteins in Cell Growth Control

2005 • 330 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Aurora B Kinase Exists in a Complex with Survivin and INCENP and Its Kinase Activity Is Stimulated by Survivin Binding and Phosphorylation

2002 • 318 citations

Prevention of T Cell Anergy by Signaling Through the γ _c Chain of the IL-2 Receptor

1994 • 311 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.

2003 • 253 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death

2000 • 233 citations

Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34+ cells by hematopoietic growth factors: implication of survivin expression in normal hematopoiesis

2001 • 213 citations

Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16INK4a and Cdk2/Cyclin E complex activation

2000 • 196 citations

Probing the Dynamics and Functions of Aurora B Kinase in Living Cells during Mitosis and Cytokinesis

2002 • 195 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.

1993 • 182 citations

Essential Role of Survivin, an Inhibitor of Apoptosis Protein, in T Cell Development, Maturation, and Homeostasis

2003 • 170 citations

Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.

1993 • 143 citations

Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That Is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo

2004 • 130 citations

Survivin Loss in Thymocytes Triggers p53-mediated Growth Arrest and p53-independent Cell Death

2004 • 129 citations

Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells

2002 • 122 citations

Function and regulation of Aurora/Ipl1p kinase family in cell division

2003 • 65 citations

TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27Kip1

2001 • 46 citations

Tumor Necrosis Factor α Inhibits Cyclin A Expression and Retinoblastoma Hyperphosphorylation Triggered by Insulin-like Growth Factor-I Induction of New E2F-1 Synthesis

2004 • 32 citations