Immune regulation and control of regulatory T cells by OX40 and 4-1BB

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

2007 • 2,575 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 • 1,744 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

2007 • 1,181 citations

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

2002 • 1,163 citations

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

2005 • 955 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

2007 • 818 citations

All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

2007 • 813 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms

2006 • 769 citations

In Vivo Instruction of Suppressor Commitment in Naive T Cells

2004 • 726 citations

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

2007 • 695 citations

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells

2004 • 654 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

2007 • 567 citations

From Vanilla to 28 Flavors: Multiple Varieties of T Regulatory Cells

2006 • 553 citations

TGF-β Induces Foxp3 + T-Regulatory Cells from CD4 + CD25 − Precursors

2004 • 527 citations

Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor

2006 • 454 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

OX40 costimulation turns off Foxp3+ Tregs

2007 • 398 citations

PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

2004 • 369 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

2004 • 305 citations

FOXP3 modifies the phenotypic and functional properties of regulatory T cells

2007 • 262 citations

Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3 ⁺ regulatory T cells

2007 • 236 citations

Costimulation of T cells by OX40, 4-1BB, and CD27

2003 • 229 citations

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

2006 • 227 citations

Immune Responses in 4-1BB (CD137)-Deficient Mice

2002 • 221 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

Cutting Edge: OX40 Inhibits TGF-β- and Antigen-Driven Conversion of Naive CD4 T Cells into CD25+Foxp3+ T cells

2007 • 202 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells

2003 • 172 citations

The 4-1BB Costimulation Augments the Proliferation of CD4+CD25+ Regulatory T Cells

2004 • 157 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling

2007 • 139 citations

LAT-mediated signaling in CD4+CD25+ regulatory T cell development

2005 • 121 citations

Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment

2006 • 118 citations

Cutting Edge: In Vitro-Generated Tolerogenic APC Induce CD8+ T Regulatory Cells That Can Suppress Ongoing Experimental Autoimmune Encephalomyelitis

2004 • 109 citations

Peptide-Specific CD8 T Regulatory Cells Use IFN-γ to Elaborate TGF-β-Based Suppression

2005 • 100 citations

CD137-mediated immunotherapy for allergic asthma

2006 • 88 citations

Costimulation by CD137/4–1BB inhibits T cell apoptosis and induces Bcl‐x_L and c‐FLIP_short via phosphatidylinositol 3‐kinase and AKT/protein kinase B

2005 • 82 citations

Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering

2003 • 71 citations

Stimulation with 4-1BB (CD137) inhibits chronic graft-versus-host disease by inducing activation-induced cell death of donor CD4+ T cells

2004 • 71 citations

Dual immunoregulatory pathways of 4-1BB signaling

2006 • 59 citations

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease

2005 • 58 citations

Modulating Protective and Pathogenic CD4+ Subsets via CD137 in Type 1 Diabetes

2006 • 56 citations

TCR transgenic CD8+ T cells activated in the presence of TGF express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection

2006 • 55 citations

4-1BB as a Therapeutic Target for Human Disease

2009 • 49 citations

4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cells

2005 • 41 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 35 citations

Costimulatory molecule-targeted immunotherapy of cutaneous graft-versus-host disease

2007 • 33 citations

Inhibition of Th2-Mediated Allergic Airway Inflammatory Disease by CD137 Costimulation

2006 • 31 citations

Regulation of Follicular Dendritic Cell Networks by Activated T Cells: The Role of CD137 Signaling

2005 • 29 citations

Immunotherapy Targeting 4-1BB and Its Ligand

2006 • 24 citations

Marked Expansion of CD11c+CD8+ T-Cells in Melanoma-bearing Mice Induced by Anti-4-1BB Monoclonal Antibody

2007 • 24 citations

OX40:OX40L Axis: Emerging Targets for Immunotherapy of Human Disease

2006 • 6 citations