The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

The Mechanism of Action of Cyclosporin A and FK506

1996 • 664 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

1996 • 464 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Control points in early T-cell development

1993 • 429 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development.

1993 • 393 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1

1996 • 375 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

The role of T-cell subsets and cytokines in the regulation of infection

1991 • 352 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

1997 • 286 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

Identification and purification of human stat proteins activated in response to interleukin-2

1995 • 223 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

Cloning of Human Stat5B

1996 • 210 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Regulation of thymocyte development from immature progenitors

1996 • 182 citations

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity

1995 • 168 citations

Cytokines in T-cell development

1991 • 164 citations

A common factor regulates both Th1- and Th2-specific cytokine gene expression.

1994 • 151 citations

The GTPase Rho has a critical regulatory role in thymus development

1997 • 135 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

Transcription Mediated by NFAT Is Highly Inducible in Effector CD4⁺ T Helper 2 (Th2) Cells but Not in Th1 Cells

1997 • 115 citations

Sox‐4 facilitates thymocyte differentiation

1997 • 105 citations

Cytokine production and requirements during T-cell development

1995 • 104 citations

Transcriptional control of lymphoid development: lessons from gene targeting

1996 • 97 citations

Different Functions of the GTPase Rho in Prothymocytes and Late Pre-T Cells

1997 • 88 citations

Interleukin 4: Signalling Mechanisms and Control of T Cell Differentiation

2007 • 77 citations

Interleukin 2 activates STAT5 transcription factor (mammary gland factor) and specific gene expression in T lymphocytes.

1995 • 74 citations

Probing immune functions in RAG-deficient mice

1994 • 51 citations

Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells

1994 • 49 citations

Calcineurin-dependent nuclear translocation of a murine transcription factor NFATx: molecular cloning and functional characterization.

1997 • 34 citations

Nuclear factors that mediate intrathymic signals are developmentally regulated.

1994 • 27 citations

RAG-2-Deficient Blastocyst Complementation

1994 • 26 citations

CORRECTIONS

1997 • 8 citations