Imaging antigen-induced PI3K activation in T cells

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

LAT

1998 • 1,251 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis

2002 • 755 citations

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

1996 • 692 citations

Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients

2002 • 686 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Leukocyte polarization in cell migration and immune interactions

1999 • 622 citations

Phospholipid signaling

1995 • 561 citations

A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

2002 • 522 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 515 citations

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

2002 • 477 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

1999 • 444 citations

Specificity and Promiscuity in Phosphoinositide Binding by Pleckstrin Homology Domains

1998 • 426 citations

Making the T Cell Receptor Go the Distance: A Topological View of T Cell Activation

1997 • 399 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Structural Basis for Discrimination of 3-Phosphoinositides by Pleckstrin Homology Domains

2000 • 330 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Signaling pathways controlling cell polarity and chemotaxis

2001 • 302 citations

Spatial Sensing in Fibroblasts Mediated by 3′ Phosphoinositides

2000 • 300 citations

Leukocytes navigate by compass: roles of PI3Kγ and its lipid products

2000 • 298 citations

PLECKSTRIN HOMOLOGY DOMAINS: A Common Fold with Diverse Functions

1998 • 289 citations

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

2002 • 281 citations

Spatial control of actin polymerization during neutrophil chemotaxis

1999 • 281 citations

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

1996 • 278 citations

Pleckstrin homology domains and the cytoskeleton

2001 • 255 citations

The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo

1999 • 192 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

Ras regulation and function in lymphocytes

2000 • 179 citations

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

2000 • 143 citations

A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets

1998 • 133 citations

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

2001 • 129 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

1999 • 124 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Rho proteins, PI 3‐kinases, and monocyte/macrophage motility

2001 • 121 citations

Distinct Phosphatidylinositol 3-Kinase Lipid Products Accumulate upon Oxidative and Osmotic Stress and Lead to Different Cellular Responses

1999 • 117 citations

TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor

2002 • 115 citations

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

2002 • 115 citations

CD28 affects the earliest signaling events generated by TCR engagement

1998 • 110 citations

Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70

2001 • 104 citations

Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo

2002 • 95 citations

Analysis of tetanus toxin peptide/DR recognition by human T cell receptors reconstituted into a murine T cell hybridoma

1993 • 70 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

The Gab1 Docking Protein Links the B Cell Antigen Receptor to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and to the SHP2 Tyrosine Phosphatase

2001 • 65 citations

Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 • 63 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy

2001 • 37 citations

Cooperation of Src Homology Domains in the Regulated Binding of Phosphatidylinositol 3-Kinase

1995 • 36 citations

Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells.

1996 • 17 citations