Augmentation Versus Inhibition: Effects of Conjunctional OX-40 Receptor Monoclonal Antibody and IL-2 Treatment on Adoptive Immunotherapy of Advanced Tumor

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

1988 • 2,196 citations

A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-Infiltrating Lymphocytes

1986 • 1,787 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Treatment of Patients With Metastatic Melanoma With Autologous Tumor-Infiltrating Lymphocytes and Interleukin 2

1994 • 991 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

New fluorescent dyes for lymphocyte migration studies

1990 • 498 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

The selection and characterization of an invasive variant of the B16 melanoma.

1979 • 376 citations

Tumor-Specific CD4+ T Cells Have a Major “Post-Licensing” Role in CTL Mediated Anti-Tumor Immunity

2000 • 337 citations

Increased Vaccine-Specific T Cell Frequency After Peptide-Based Vaccination Correlates with Increased Susceptibility to In Vitro Stimulation But Does Not Lead to Tumor Regression

1999 • 290 citations

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

1999 • 287 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Danger and OX40 Receptor Signaling Synergize to Enhance Memory T Cell Survival by Inhibiting Peripheral Deletion

2000 • 222 citations

Studies on the chemotherapy of experimental brain tumors: development of an experimental model.

1970 • 221 citations

Specific adoptive immunotherapy mediated by tumor-draining lymph node cells sequentially activated with anti-CD3 and IL-2.

1991 • 217 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

The Murine Antitumor Immune Response and Its Therapeutic Manipulation

1984 • 164 citations

Control of Syngeneic Tumor Growth by Activation of CD8+ T Cells: Efficacy Is Limited by Migration Away from the Site and Induction of Nonresponsiveness

1999 • 146 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

Adoptive immunotherapy of newly induced murine sarcomas.

1985 • 137 citations

Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy.

1987 • 129 citations

The First Subcomponent of Complement, C1q, Triggers the Production of IL-8, IL-6, and Monocyte Chemoattractant Peptide-1 by Human Umbilical Vein Endothelial Cells

1998 • 127 citations

Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy.

1999 • 115 citations

Purification of L-Selectinlow Cells Promotes the Generation of Highly Potent CD4 Antitumor Effector T Lymphocytes

1998 • 110 citations

Generation of therapeutic T lymphocytes from tumor-bearing mice by in vitro sensitization. Culture requirements and characterization of immunologic specificity.

1988 • 99 citations

Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation.

2001 • 92 citations

Relapse in the central nervous system in melanoma patients successfully treated with biomodulators.

1989 • 89 citations

Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier

1988 • 82 citations

Isolation based on L-selectin expression of immune effector T cells derived from tumor-draining lymph nodes.

1996 • 80 citations

Activation by anti-CD3 of tumor-draining lymph node cells for specific adoptive immunotherapy

1991 • 75 citations

Tumor Infiltration by Adoptively Transferred T Cells Is Independent of Immunologic Specificity but Requires Down-Regulation of L-Selectin Expression

1999 • 67 citations

The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells

1998 • 67 citations

Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene.

1988 • 62 citations

The effect of intravenous interleukin-2 on brain water content

1989 • 61 citations

Cellular interactions in effector cell generation and tumor regression mediated by anti-CD3/interleukin 2-activated tumor-draining lymph node cells.

1992 • 55 citations

Effects of ionizing radiation on the blood brain barrier permeability to pharmacologically active substances

1990 • 55 citations

Treatment of Subcutaneous Tumor with Adoptively Transferred T Cells

1997 • 54 citations

Somatic gene therapy. Current status and future prospects.

1986 • 49 citations

Considerations for the Use of Cytokine-Secreting Tumor Cell Preparations for Cancer Treatment

1995 • 46 citations

Adoptive immunotherapy of a syngeneic murine leukemia with a tumor-specific cytotoxic T cell clone and recombinant human interleukin 2: correlation with clonal IL 2 receptor expression.

1986 • 44 citations

Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunologic memory.

1987 • 44 citations

Calcein: A novel marker for lymphocytes which enter lymph nodes

1992 • 41 citations

Critical Role of CD11a (LFA-1) in Therapeutic Efficacy of Systemically Transferred Antitumor Effector T Cells

1999 • 37 citations

Helper-Independent, L-Selectinlow CD8+ T Cells with Broad Anti-Tumor Efficacy Are Naturally Sensitized During Tumor Progression

2000 • 35 citations

Gene therapy: current status and future prospects

1994 • 27 citations

Adoptive Immunotherapy of Murine Intracerebral Tumors with Anti-CD3/Interleukin-2-Activated Tumor-Draining Lymph Node Cells

1994 • 24 citations

Unique Characteristics Associated with Systemic Adoptive Immunotherapy of Experimental Intracerebral Tumors

1995 • 24 citations

Antagonistic effects of systemic interleukin 2 on immune Tcell-mediated graft-versus-leukemia reactivity.

1998 • 10 citations

Local versus systemic interleukin-2: Tumor formation by wild-type and B7-1-positive murine melanoma cells

2000 • 10 citations