CD134-Allodepletion Allows Selective Elimination of Alloreactive Human T Cells without Loss of Virus-Specific and Leukemia-Specific Effectors

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Blockade of Programmed Death-1 Ligands on Dendritic Cells Enhances T Cell Activation and Cytokine Production

2003 • 933 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

2003 • 848 citations

HYPOFERRÆMIA IN OBESE ADOLESCENTS

1962 • 650 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

Developmental Stage, Phenotype, and Migration Distinguish Naive- and Effector/Memory-like CD4+ Regulatory T Cells

2004 • 618 citations

Transplantation of Anergic Histoincompatible Bone Marrow Allografts

1999 • 448 citations

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

1984 • 436 citations

The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation

2001 • 432 citations

Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR

2005 • 406 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

TRANSPLANTATION FOR ACUTE LEUKAEMIA WITH HLA-A AND B NONIDENTICAL PARENTAL MARROW CELLS FRACTIONATED WITH SOYBEAN AGGLUTININ AND SHEEP RED BLOOD CELLS

1981 • 385 citations

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

2001 • 352 citations

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

1992 • 339 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

PROLONGED PERITONEAL DIALYSIS FOR CHRONIC RENAL FAILURE

1964 • 328 citations

4-1BB-mediated immunotherapy of rheumatoid arthritis

2004 • 324 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation

2006 • 245 citations

Sustained Survivin Expression from OX40 Costimulatory Signals Drives T Cell Clonal Expansion

2005 • 243 citations

Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study

2002 • 225 citations

Immune Responses in 4-1BB (CD137)-Deficient Mice

2002 • 221 citations

USE OF ANTI-T-CELL MONOCLONAL ANTIBODY OKT3 TO PREVENT ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA

1982 • 220 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.

1997 • 193 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses

2003 • 153 citations

PRETREATMENT OF DONOR BONE MARROW WITH MONOCLONAL ANTIBODY OKT3 FOR PREVENTION OF ACUTE GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC HISTOCOMPATIBLE BONE-MARROW TRANSPLANTATION

1982 • 153 citations

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation

2005 • 144 citations

Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft- versus-host disease and extend the donor pool

1996 • 138 citations

Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation

1993 • 134 citations

Depletion of Alloreactive T Cells by a Specific Anti–Interleukin-2 Receptor p55 Chain Immunotoxin Does Not Impair In Vitro Antileukemia and Antiviral Activity

1999 • 122 citations

T-Cell Responses Directed against Multiple HLA-A*0201-Restricted Epitopes Derived from Wilms' Tumor 1 Protein in Patients with Leukemia and Healthy Donors: Identification, Quantification, and Characterization

2005 • 114 citations

Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation

2000 • 105 citations

Anti‐OX40 stimulation in vivo enhances CD8⁺ memory T cell survival and significantly increases recall responses

2006 • 95 citations

A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions

2004 • 87 citations

Functional assessment and specific depletion of alloreactive human T cells using flow cytometry

2004 • 87 citations

Reinventing bone marrow transplantation: reducing toxicity using nonmyeloablative, preparative regimens and induction of graft-versus-malignancy

1999 • 85 citations

Expression of the T-Cell Activation Antigen, OX-40, Identifies Alloreactive T Cells in Acute Graft-Versus-Host Disease

1997 • 83 citations

Early reactivation of cytomegalovirus and high risk of interstitial pneumonitis following T-depleted BMT for adults with hematological malignancies.

1996 • 83 citations

Costimulation by CD137/4–1BB inhibits T cell apoptosis and induces Bcl‐x_L and c‐FLIP_short via phosphatidylinositol 3‐kinase and AKT/protein kinase B

2005 • 82 citations

SPECIFIC ELIMINATION OF ALLOREACTIVE T CELLS BY AN ANTI-INTERLEUKIN-2 RECEPTOR B CHAIN-SPECIFIC IMMUNOTOXIN

1990 • 81 citations

Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease

2007 • 79 citations

Specific depletion of alloreactivity against haplotype mismatched related individuals by a recombinant immunotoxin: a new approach to graft-versus-host disease prophylaxis in haploidentical bone marrow transplantation.

1996 • 71 citations

Enhanced CD4 T Cell Responsiveness in the Absence of 4-1BB

2005 • 66 citations

Selective depletion of major and minor histocompatibility antigen reactive T cells: towards prevention of acute graft‐versus‐host disease

1999 • 63 citations

Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor

1999 • 61 citations

Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation

2002 • 61 citations

Engagement of 4-1BB Inhibits the Development of Experimental Allergic Conjunctivitis in Mice

2005 • 59 citations

ALLOGENEIC HEMATOPOIETIC TRANSPLANTATION AS ADOPTIVE IMMUNOTHERAPY

1999 • 57 citations

Effect of anti-T-cell globulin on GVHD in leukemic patients treated with BMT.

1981 • 55 citations

OX40 (CD134) engagement drives differentiationof CD4⁺ T cells to effector cells

2006 • 53 citations

Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation

2001 • 47 citations

Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2–producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation

2003 • 45 citations

Alloantigen‐specific T‐cell depletion in a major histocompatibility complex fully mismatched murine model provides effective graft‐versus‐host disease prophylaxis in the presence of lymphoid engraftment

2002 • 39 citations

Activation-associated phenotype of CD3+ T cells in acute graft-versus-host disease

2006 • 28 citations

CD137‐Mediated T Cell Co‐Stimulation Terminates Existing Autoimmune Disease in SLE‐Prone NZB/NZW F1 Mice

2003 • 26 citations

Roles of OX40 in the Pathogenesis and the Control of Diseases

2006 • 21 citations

Functional study of residual T lymphocytes after specific elimination of alloreactive T cells by a specific anti-interleukin-2 receptor Bk chain immunotoxin.

1993 • 19 citations

Differential cellular immune responsiveness to systems of the major histocompatibility complex

1976 • 5 citations