Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue

2001 • 1,922 citations

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

Molecular and Functional Profiling of Memory CD8 T Cell Differentiation

2002 • 962 citations

IMMUNODOMINANCE IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS I–RESTRICTED T LYMPHOCYTE RESPONSES

1999 • 923 citations

Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response Magnitude

2007 • 918 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Recombinant vesicular stomatitis viruses from DNA.

1995 • 604 citations

Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells

2002 • 584 citations

Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996. 274: 94-96.

2011 • 539 citations

Coordinate Regulation of Complex T Cell Populations Responding to Bacterial Infection

1998 • 535 citations

Initial T cell frequency dictates memory CD8+ T cell lineage commitment

2005 • 458 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

2007 • 415 citations

Activated Antigen-Specific CD8+ T Cells Persist in the Lungs Following Recovery from Respiratory Virus Infections

2001 • 403 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

Impact of Negative Selection on the T Cell Repertoire Reactive to a Self-Peptide

2000 • 377 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes

2000 • 297 citations

Differential contributions of central and effector memory T cells to recall responses

2005 • 275 citations

Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

2006 • 240 citations

L-selectin: mechanisms and physiological significance of ectodomain cleavage

2005 • 235 citations

Down-regulation of homing receptors after T cell activation.

1988 • 235 citations

Individual Variations in the Murine T Cell Response to a Specific Peptide Reflect Variability in Naive Repertoires

1998 • 192 citations

Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen

1993 • 181 citations

Development, trafficking, and function of memory T‐cell subsets

2006 • 153 citations

Genome-Wide Analysis Reveals a Highly Diverse CD8 T Cell Response to Murine Cytomegalovirus

2006 • 152 citations

Evidence that a significant number of naive T cells enter non‐lymphoid organs as part of a normal migratory pathway

2006 • 151 citations

Direct Analysis of the Dynamics of the Intestinal Mucosa CD8 T Cell Response to Systemic Virus Infection

2001 • 147 citations

Stop and Go Traffic to Tune T Cell Responses

2004 • 143 citations

Expression of Intestine-Specific Antigen Reveals Novel Pathways of CD8 T Cell Tolerance Induction

2000 • 138 citations

Strength of Stimulus and Clonal Competition Impact the Rate of Memory CD8 T Cell Differentiation

2007 • 132 citations

Temporal loss of the activated L-selectin-low phenotype for virus-specific CD8+ memory T cells.

1995 • 130 citations

Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals

1998 • 122 citations

IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections

2006 • 117 citations

In Situ Imaging of the Endogenous CD8 T Cell Response to Infection

2007 • 109 citations

Soluble Antigen and CD40 Triggering Are Sufficient to Induce Primary and Memory Cytotoxic T Cells

2000 • 104 citations

Rapid Expansion and IL-4 Expression by Leishmania-Specific Naive Helper T Cells In Vivo

2002 • 92 citations

Ultrasensitive Detection and Phenotyping of CD4+ T Cells with Optimized HLA Class II Tetramer Staining

2005 • 91 citations

Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells

2007 • 87 citations

Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage

2006 • 83 citations

Very Diverse CD8 T Cell Clonotypic Responses after Virus Infections

2004 • 61 citations

Expression of T-cell receptor alpha-chain genes in transgenic mice.

1988 • 60 citations

IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection

2004 • 60 citations

Structure and duration of contact between dendritic cells and T cells are controlled by T cell activation state

2006 • 60 citations

Ultra‐sensitive class I tetramer analysis reveals previously undetectable populations of antiviral CD8⁺ T cells

2004 • 54 citations

Expression and function of AIM, an activation inducer molecule of human lymphocytes, is dependent on the activation of protein kinase C

1989 • 48 citations

T Cell Clonal Conditioning: A Phase Occurring Early after Antigen Presentation but before Clonal Expansion Is Impacted by Toll-Like Receptor Stimulation

2004 • 48 citations

Consequences of Cross-Reactive and Bystander CTL Responses during Viral Infections

2000 • 38 citations

Single amino acid replacements in an antigenic peptide are sufficient to alter the TCR V beta repertoire of the responding CD8+ cytotoxic lymphocyte population.

1999 • 27 citations

Single Amino Acid Replacements in an Antigenic Peptide Are Sufficient to Alter the TCR Vβ Repertoire of the Responding CD8+ Cytotoxic Lymphocyte Population

1999 • 23 citations

Expression of T-cell Receptor Alpha-Chain Genes in Transgenic Mice

1988 • 21 citations

T Cell Conditioning Explains Early Disappearance of the Memory CD8 T Cell Response to Infection

2006 • 18 citations

Optimization of TCR transgenic T cells for in vivo tracking of immune responses

2007 • 16 citations

Reversibility of Loss of Homing Receptor Expression Following Activation

1988 • 11 citations