Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) Pathway Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice

Inflammation, Atherosclerosis, and Coronary Artery Disease

2005 • 8,367 citations

The immune response in atherosclerosis: a double-edged sword

2006 • 2,116 citations

Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways

2006 • 1,615 citations

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

2005 • 1,029 citations

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

2000 • 669 citations

Innate and acquired immunity in atherogenesis

2002 • 661 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Requirement for CD154 in the progression of atherosclerosis

1999 • 437 citations

The Role of Interleukin-4 and Interleukin-12 in the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice

2003 • 423 citations

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

2004 • 406 citations

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

2000 • 353 citations

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

2004 • 349 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

Induction of a Regulatory T Cell Type 1 Response Reduces the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice

2003 • 296 citations

Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

1987 • 286 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.

1996 • 284 citations

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

2005 • 276 citations

Both early and delayed anti-CD40L antibody treatment induces a stable plaque phenotype

2000 • 263 citations

Thematic review series: The Immune System and Atherogenesis. The role of natural antibodies in atherogenesis

2005 • 251 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Apolipoprotein E–Deficient and Low-Density Lipoprotein Receptor–Deficient Mice

2001 • 232 citations

Defective B-1 Cell Development and Impaired Immunity against Angiostrongylus cantonensis in IL-5Rα-Deficient Mice

1996 • 223 citations

CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice

2001 • 207 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

OX40 ligand shuts down IL-10-producing regulatory T cells

2006 • 193 citations

Regulation of T Cell Activation In Vitro and In Vivo by Targeting the OX40-OX40 Ligand Interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, But Not with an OX40 Ligand-IgG Fusion Protein

1999 • 172 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Role of Ox40 Signals in Coordinating Cd4 T Cell Selection, Migration, and Cytokine Differentiation in T Helper (Th)1 and Th2 Cells

2000 • 143 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

The Role of IL-5 for Mature B-1 Cells in Homeostatic Proliferation, Cell Survival, and Ig Production

2004 • 129 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

PKC-θ-Deficient Mice Are Protected from Th1-Dependent Antigen-Induced Arthritis

2006 • 102 citations

Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40

2000 • 93 citations

An Hour after Immunization Peritoneal B-1 Cells Are Activated to Migrate to Lymphoid Organs Where within 1 Day They Produce IgM Antibodies That Initiate Elicitation of Contact Sensitivity

2005 • 73 citations

CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis

2003 • 64 citations

OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses

2003 • 51 citations

Correlation of peripheral blood OX40+(CD134+) T cells with chronic graft-versus-host disease in patients who underwent allogeneic hematopoietic stem cell transplantation

2001 • 47 citations

Role of interleukin-4 in atherosclerosis

2006 • 39 citations

Human genetic evidence that OX40 is implicated in myocardial infarction

2005 • 38 citations

Identification of OX40 ligand and preliminary characterization of its activities on OX40 receptor.

1994 • 24 citations

Neo-self Antigens and the Expansion of B-1 Cells: Lessons from Atherosclerosis-prone Mice

2000 • 21 citations