Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

Mfold web server for nucleic acid folding and hybridization prediction

2003 • 12,790 citations

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Aptamers: An Emerging Class of Therapeutics

2005 • 915 citations

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

2008 • 892 citations

Immunostimulatory monoclonal antibodies for cancer therapy

2007 • 596 citations

RNA aptamers as reversible antagonists of coagulation factor IXa

2002 • 506 citations

4-1BB and Ox40 Are Members of a Tumor Necrosis Factor (TNF)-Nerve Growth Factor Receptor Subfamily That Bind TNF Receptor-Associated Factors and Activate Nuclear Factor κB

1998 • 342 citations

Direct In Vitro Selection of a 2′-O-Methyl Aptamer to VEGF

2005 • 328 citations

Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

2004 • 320 citations

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

2008 • 296 citations

First-in-Human Experience of an Antidote-Controlled Anticoagulant Using RNA Aptamer Technology

2006 • 212 citations

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity.

2003 • 185 citations

Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

1998 • 181 citations

[17] A SELEX primer

1996 • 169 citations

Vaccination against the Forkhead Family Transcription Factor Foxp3 Enhances Tumor Immunity

2007 • 146 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

The Crystal Structure of the Costimulatory OX40-OX40L Complex

2006 • 131 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

Anti‐metastatic vaccination of tumor‐bearing mice with il‐2‐gene‐inserted tumor cells

1993 • 99 citations

Pegaptanib 1-Year Systemic Safety Results from a Safety–Pharmacokinetic Trial in Patients with Neovascular Age-Related Macular Degeneration

2007 • 95 citations

A Novel Antidote-Controlled Anticoagulant Reduces Thrombin Generation and Inflammation and Improves Cardiac Function in Cardiopulmonary Bypass Surgery

2006 • 80 citations

Activation of cytotoxic T cells by nonstimulating tumor cells and spleen cell factor(s).

1977 • 70 citations

C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L

2005 • 66 citations

Simultaneous Generation of Aptamers to Multiple Gamma-Carboxyglutamic Acid Proteins from a Focused Aptamer Library Using DeSELEX and Convergent Selection

2007 • 59 citations

Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain

2007 • 59 citations

Anti-tumour therapeutic efficacy of OX40L in murine tumour model

2004 • 58 citations

Anti-OX40 (CD134) Administration to Nonhuman Primates: Immunostimulatory Effects and Toxicokinetic Study

2006 • 57 citations

H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity

2006 • 48 citations

RNA-transfected dendritic cells

2002 • 21 citations