The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Ox-40 Ligand: A Potent Costimulatory Molecule for Sustaining Primary CD4 T Cell Responses

1998 • 515 citations

Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion.

1993 • 502 citations

Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts

1987 • 453 citations

Expression and function of OX40 ligand on human dendritic cells.

1997 • 416 citations

The OX40 Costimulatory Receptor Determines the Development of CD4 Memory by Regulating Primary Clonal Expansion

2000 • 395 citations

CD4 T Cell Cytokine Differentiation: The B Cell Activation Molecule, OX40 Ligand, Instructs CD4 T Cells to Express Interleukin 4 and Upregulates Expression of the Chemokine Receptor, Blr-1

1998 • 358 citations

T cell co-stimulatory molecules other than CD28

1999 • 349 citations

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

1996 • 303 citations

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.

1996 • 284 citations

Blocking OX-40/OX-40 Ligand Interaction In Vitro and In Vivo Leads to Decreased T Cell Function and Amelioration of Experimental Allergic Encephalomyelitis

1999 • 250 citations

Primed Allospecific T Cells Prevent the Effects of Costimulatory Blockade on Prolonged Cardiac Allograft Survival in Mice

2002 • 237 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Critical Contribution of Ox40 Ligand to T Helper Cell Type 2 Differentiation in Experimental Leishmaniasis

2000 • 235 citations

Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions.

1993 • 205 citations

Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth.

2000 • 196 citations

CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles

1999 • 190 citations

CD28-Independent Costimulation of T Cells by OX40 Ligand and CD70 on Activated B Cells

1999 • 180 citations

Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis.

1996 • 179 citations

The Role of Novel T Cell Costimulatory Pathways in Autoimmunity and Transplantation

2002 • 165 citations

Host CD40 Ligand Deficiency Induces Long-Term Allograft Survival and Donor-Specific Tolerance in Mouse Cardiac Transplantation But Does Not Prevent Graft Arteriosclerosis

2000 • 154 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 151 citations

Contribution of OX40/OX40 ligand interaction to the pathogenesis of rheumatoid arthritis

2000 • 138 citations

OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand

1996 • 138 citations

The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo

2000 • 135 citations

Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection.

1998 • 129 citations

IL-1 Enhances T Cell-Dependent Antibody Production Through Induction of CD40 Ligand and OX40 on T Cells

2001 • 125 citations

The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen

1994 • 124 citations

CD28-independent Costimulation of T Cells in Alloimmune Responses

2001 • 117 citations

DONOR ANTIGEN IS NECESSARY FOR THE PREVENTION OF CHRONIC REJECTION IN CTLA4IG-TREATED MURINE CARDIAC ALLOGRAFT RECIPIENTS1,2

1997 • 114 citations

OX40: targeted immunotherapy - implications for tempering autoimmunity and enhancing vaccines

2002 • 112 citations

Amelioration of Experimental Autoimmune Encephalomyelitis with Anti-OX40 Ligand Monoclonal Antibody: A Critical Role for OX40 Ligand in Migration, But Not Development, of Pathogenic T Cells

2001 • 110 citations

THE CD154-CD40 COSTIMULATORY PATHWAY IN TRANSPLANTATION

2002 • 95 citations

Expression of the T-Cell Activation Antigen, OX-40, Identifies Alloreactive T Cells in Acute Graft-Versus-Host Disease

1997 • 83 citations

CD28-independent induction of experimental autoimmune encephalomyelitis

2001 • 75 citations

The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells

1998 • 67 citations

CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses.

1997 • 49 citations

OX‐40 antibody enhances for autoantigen specific Vβ8.2⁺ T cells within the spinal cord of lewis rats with autoimmune encephalomyelitis

1996 • 41 citations

Characterization of rat CD80 and CD86 by molecular cloning and mAb

1997 • 41 citations

Mechanisms of targeting cd28 by a signaling monoclonal antibody in acute and chronic allograft rejection1

2002 • 38 citations

USE OF CTLA4-Ig IN COMBINATION WITH CONVENTIONAL IMMUNOSUPPRESSIVE AGENTS TO PROLONG ALLOGRAFT SURVIVAL

1997 • 35 citations

Immunosuppression through biockade of CD28:B7-mediated costimulatory signals

1996 • 34 citations

V? CDR3 motifs associated with BP recognition are enriched in OX-40+ spinal cord T cells of lewis rats with EAE

1996 • 34 citations

Localization of OX40/gp34 in inflammatory skin diseases: a clue to elucidate the interaction between activated T cells and endothelial cells in infiltration

1997 • 32 citations

A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection1

2002 • 25 citations

CTLA4IG INDUCES LONG-TERM GRAFT SURVIVAL OF ALLOGENEIC SKIN GRAFTS AND TOTALLY INHIBITS T-CELL PROLIFERATION IN LFA-1???DEFICIENT MICE

2002 • 25 citations

Characterization of Rat OX40 Ligand by Monoclonal Antibody

2000 • 15 citations

Aggressive skin allograft rejection in CD28−/− mice independent of the CD40/CD40L costimulatory pathway

2001 • 12 citations